Systematic review and meta-analysis of endometrial thickening during endocrine therapy combined with Chinese herbal medicine intervention after breast cancer surgery

Objective:To systematically evaluate the endometrial thickening and Chinese herbal medicine intervention effects during endocrine therapy following breast cancer surgery.Methods:Computerized searches were performed on CNKI,CBM,Wanfang,VIP,Pub Med,Embase,and Cochrane to gather randomized controlled trials(RCTs)of endometrial thickening combined with Chinese herbal medicine intervention during endocrine therapy after breast cancer surgery.The meta analysis is done using Rev Man 5.4,and the retrieval range is from the database's creation to January 2023.Results:There were 710 patients enrolled in a total of 12 RCTs.The results of Meta-analysis were as follows:combined with Chinese herbal medicine treatment for 3 months of endometrial thickness(MD=-1.12,95%CI[-1.47,0.77],P<0.00001);6 months endometrial thickness(MD=-1.90,95%CI[-2.38,-1.42],P<0.00001);endometrial thickness at 12 months(MD=-2.24,95%CI[-2.96,-1.52],P<0.00001);modified Kupperman score(MD=-10.45,95%CI[-19.10,-1.80],P=0.02);TCM syndrome score(SMD=-1.53,95%CI[-1.84,-1.22],P<0.00001);KPS score(MD=3.75,95%CI[2.81,4.68],P<0.00001);there was no significant difference in CA153,CEA,FSH and E2 between the two groups.Conclusion:After breast cancer surgery,endocrine therapy combined with Chinese herbal medicine can significantly lessen endometrial thickening and enhance patient quality of life.

Analysis of the Law of Huang Lijuan in Treating Chronic Heart Failure Based on Auxiliary Platform of Traditional Chinese Medicine

Objective:To analyze the prescription of Huang Lijuan in the treatment of chronic heart failure based on the TCM inheritance platform. Methods:Professor Huang Lijuan's outpatient medical treatment for chronic heart failure was collected, and the medical record database was established by using the Chinese medicine inheritance auxiliary platform. Based on the software's integrated rule analysis, improved mutual information method, complex system entropy clustering analysis and other data mining methods, Professor Huang Lijuan summed up the treatment of chronic heart failure. Results:A total of 114 prescriptions for treating chronic cardiac insufficiency were prepared by Professor Huang Lijuan. A total of 108 Chinese herbal medicines were used. The frequency of use was the highest in jaundice, salvia, and medlar. The four gases of the drug are mainly temperate;the drug has the most sweet taste in the five flavors;the drug is followed by the liver, and the heart rate is the highest. There are 32 groups of commonly used drug combinations;48 groups of common horn drugs are combined, and the map shows the drug association degree network, 6 core groups, and 3 new sites. Conclusions:Professor Huang Lijuan is treating the chronic heart failure with the benefits of temperature and yang, promoting blood circulation and diuresis as the basic treatment, and also relies on diarrhea and lung water and replenishing heart and yin.

A rare occurrence of a hereditary Birt-Hogg-Dubésyndrome:A case report

BACKGROUND Birt-Hogg-Dubé(BHD)syndrome is a rare autosomal dominant disease caused by germline mutations in the folliculin(FLCN)protein gene,which usually manifests as cutaneous fibrofolliculoma,pulmonary cysts,renal cell carcinoma,and spontaneous pneumothorax.CASE SUMMARY A 26-year-old woman with no history of smoking was admitted to the Respiratory Department of our hospital due to intermittent wheezing that lasted for 8 mo.She had experienced recurrent spontaneous pneumothorax more than four times during the past 8 mo.After admission,the patient again suffered from left pneumothorax without a clear reason.Lung computed tomography(CT)showed multiple low-density cystic changes in both lungs.Physical examination on admission revealed multiple white dome-shaped papules in the neck,the nape,and behind the ear.In addition,the patient had a family history of spontaneous pneumothorax.Her mother had suffered from pneumothorax four times(at age 36,37,42,and 50 years).Her second maternal aunt had suffered from a right pneumothorax at the age of 40.The multidisciplinary diagnosis of BHD,which included the Respiratory Department,Radiology Department,Pathology Department,and Dermatological Department,was BHD and was later confirmed by family genetic testing.The same variation(FLCN gene)was found in the patient’s mother and aunt.CONCLUSION This case highlights the importance of multidisciplinary diagnosis and a treatment platform for the diagnosis of BHD.

Effect of Different Drying Processes on Active Ingredients of Rheum officinale Baill.

[Objectives]To determine the drying process of different functional rhubarbs.[Methods]The contents of tannins,bianthrone,free anthraquinones and combined anthraquinones in medicinal rhubarb were determined by HPLC.The results were analyzed by two-way analysis of variance.[Results]Under different drying conditions,the contents of tannins,bianthrone,free anthraquinones and combined anthraquinones in medicinal rhubarb were significantly different.Taking the tannins content as the index,the optimum drying condition of the rhizome is 1 cm thick,dried at 60℃,the root is cut 1 cm thick,and dried at 30℃;the bianthrone content is used as an indicator,the rhizome is optimally dried.The condition is to cut 1 cm thick,dry at 60℃,the root is cut to 5 cm thick,and dried at 40℃;the free anthraquinones content is used as an index,and the optimum drying condition of the rhizome is 3 cm thick and dried at 50℃.The root is cut to a thickness of 3 cm and dried at 30℃.The combine anthraquinones content is used as an indicator.The optimum drying conditions for the rhizome are 5 cm thick,dried at 40℃,and the root is cut to 5 cm thick and dried at 70℃.[Conclusions]Different functional components of rhubarb have different directional processing methods.The drying process can reduce the drying temperature or increase the thickness of the slice,and the directional processing of the diarrhea-type rhubarb can be processed.The drying process can be carried out by increasing the drying temperature or reducing the thickness of the slice directed processing of heat-clearing and purging-fire rhubarb.

Study on immunological characteristics of T lymphocyte in peripheral blood from patients with sjogren's syndrome

Objective: To study on in immunological characteristics of T lymphocyte in peripheral blood from patients with Sjogren's syndrome (SS), provide the theory basis for the further research of Traditional Chinese medicine (TCM) targeted therapy.Methods:T lymphocyte subsets in peripheral blood from SS, RA and normal control groups were tested with various monocbnal antibodies and multicolor flow cytometry.T lymphocyte subsets were tested in peripheral blood from SS patients of different TCM Syndromes. The relationship between T Lymphocyte subsets and disease activity was measured by erythrocyte sedimentation rate (SR)and serum IgG. Results: The percentage of CD4^+T cells and the ration of CD4^+/CD8^+T cells in peripheral bbod from SS patients decreased significantly, and the percentage of CD8^+T cells increased than that in control groups (P<0.05). Compared with patients in inactive period, the percentage of CD4^+T cells in peripheral bLood from SS patients in the active stage increased (P>0.05), the percentage of CD8^+T cells decreased (P>0.05), and the ration of CD4^+/ CD8^+T cells increased (P<0.05).Compared with control groups, the percentage of CD69 expressed on T cells in peripheral blood from SS patients decreased, and the percentage of CD95's expression increased (P<0.05).The percentage of CD69CD95's expression also increased (P>0.05). There were no differences among CD4^+T cells, CD8^+T ceLs and CD4^+/ CD8^+ in peripheral blood from SS patients of different TCM Syndromes (P>0.05). CD69 and CD95's expression on SS patients of different TCM Syndromes was no significantLy different (P>0.05).T cell receptor Vβ(TCR Vβ) subfamilies gene in peripheral blood from SS patients and control groups were expressed in all. Compared witji control groups, Vβ 5.3,Vβ 13.1,Vβ 12,Vβ 7.2 had significant differences (P<0.05).Comparison of different TCM Syndromes in SS group: Vβ 13.1 and Vβ 14 were significantly different (P<0.05).Conclusion:There was dysimmunity on T lymphocyte subsets in peripheral blood of SS patients, which was related to disease activity;apoptosis after activation of autoreactive T cell may be induced by Chinese medicine;TCR Vβ subfamilies of different TCM syndromes were different, which noted that different autoreactive T cells of abnormal activation tended to result in different expression of TCM Different syndromes.

Effectiveness of Integrative Medicine Therapy on Coronary Artery Disease Prognosis: A Real-World Study

Objective: To evaluate the effectiveness of integrative medicine(IM) on patients with coronary artery disease(CAD) and investigate the prognostic factors of CAD in a real-world setting. Methods: A total of 1,087 hospitalized patients with CAD from four hospitals in Beijing, China were consecutively selected between August 2011 and February 2012. The patients were assigned to two groups based on the treatment: Chinese medicine(CM) plus conventional treatment, i.e., IM therapy(IM group); or conventional treatment alone(CT group). The endpoint was major adverse cardiac events [MACE; including cardiac death, myocardial infarction(MI), and revascularization]. Results: A total of 1,040 patients finished the 2-year follow-up. Of them, 49.4%(514/1,040) received IM therapy. During the 2-year follow-up, the total incidence of MACE was 11.3%. Most of the events involved revascularization(9.3%). Cardiac death/MI occurred in 3.0% of cases. For revascularization, logistic stepwise regression analysis revealed that age 65 years [odds ratio(OR), 2.224], MI(OR, 2.561), diabetes mellitus(OR, 1.650), multi-vessel lesions(OR, 2.554), baseline high sensitivity C-reactive protein level 3 mg/L(OR, 1.678), and moderate or severe anxiety/depression(OR, 1.849) were negative predictors(P<0.05); while anti-platelet agents(OR, 0.422), β-blockers(OR, 0.626), statins(OR, 0.318), and IM therapy(OR, 0.583) were protective predictors(P<0.05). For cardiac death/MI, age 65 years(OR, 6.389) and heart failure(OR, 7.969) were negative predictors(P<0.05), while statin use(OR, 0.323) was a protective predictor(P<0.05) and IM therapy showed a beneficial tendency(OR, 0.587), although the difference was not statistically significant(P=0.218). Conclusion: In a real-world setting, for patients with CAD, IM therapy was associated with a decreased incidence of revascularization and showed a potential benefit in reducing the incidence of cardiac death or MI.

Correlation analysis between characteristics under gastroscope and image information of tongue in patients with chronic gastritis

OBJECTIVE:To explore the correlation between diagnostic information of tongue and gastroscopy results of patients with chronic gastritis.METHODS:Frequent pattern growth(FP-Growth),SPSS Modeler was used to analyze the correlation rules between the image information of tongue parameters and the characteristics of the stomach and duodenum seen under gastroscopy.RESULTS:Ranking in order of confidence:cyanotic tongue,slippery fur,yellow fur and spotted tongue were sequently associated with both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.L,one value of tongue coating color,which counted among(30,60),tooth-marked tongue and b,one value of tongue coating color,which counted in the range of(5,20)were sequently associated with gastric antrum mucosal erythema/macula.A,one value of tongue body color,which counted in the range of(0,20),was related to both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.a,one value of tongue coating color,which counted in the range of(15,35),was associated with gastric antrum mucosal erythema/macula.There are a total of 9 strong correlation rules.CONCLUSIONS:Cyanotic tongue,slippery fur,yellow fur,the CIE Lab value of tongue coating,a,the value of tongue body color,spotted tongue,and tooth-marked tongue are all related to the gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.The conditions of gastric mucosa could be predicted by the examination of the above related image information of tongue.

Effects of Modified Sanhuang Decoction (加味三黄汤) Enemaon Serum Tumor Necrosis Factor-α and Colonic Mucosa Interleukin-1β,Interleukin-6 Levels in Ulcerative Colitis Rats

Objective：To investigate the effects of Modified Sanhuang Decoction（加味三黄汤,MSD）enema on the serum tumor necrosis factor alpha（TNF-α）and colonic mucosa interleukin-1β（IL-1β）,interleukin-6（IL-6）levels in experimental ulcerative colitis（UC）rats.Methods：Forty-five male Wistar rats were randomly divided into 4 groups：normal group（n=12）,model group（n=11）,salazosulfapyridine（SASP）group（n=11）and MSD group（n=11）.The UC model was induced by 2,4,6-trinitrobenzene sulfonic acid（TNBS）/ethanol solution.Rats in the normal group and model group were clystered with 0.9%normal saline,while in the SASP group and MSD group were clystered with SASP and MSD enema,respectively.After drug administration（10 mL/kg body weight,for 7 days）,colonic gross changes and colonic mucosa histology were observed,serum TNF-αand colonic mucosa IL-1β,IL-6 levels were tested by enzyme linked immunosorbent assay and radioimmunoassay,respectively.Results：As compared with the normal group,the experimental UC rats,the colonic mucosal damage index scores（CMDIs）,histopathological scores（HS）and the serum TNF-a and colonic mucosa IL-1β,IL-6 levels significantly increased（P〈0.05 or P〈0.01）.In the MSD and SASP groups,the ulcer area significantly reduced,and edema disappeared.The CMDIs,HS,the serum TNF-a and colonic mucosa IL-1β,IL-6 levels in the MSD and SASP groups significantly decreased（P〈0.05 or P〈0.01）compared with the model group.The CMDIs in the MSD group were lower than that in the SASP group（P〈0.05）,but there were no significant differences in HS,serum TNF-αor colonic mucosa IL-1β,IL-6 levels between the MSD and SASP groups.Conclusion：MSD enema can improve colonic mucosa impairment and decrease serum TNF-αand colonic mucosa IL-1β,IL-6 levels in experimental UC.

Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment:A Randomized Controlled Trial

Objective:To evaluate the clinical effectiveness and safety of the Chinese medicine(CM)Qixiong Zhongzi Decoction(芪芎种子汤,QZD)in the treatment of patients with idiopathic asthenozoospermia.Methods:A total number of 66 patients with idiopathic asthenozoospermia were included and randomly divided into treatment and control groups by SAS-generated code from January 2015 to August 2016,33 patients in each group.Patients in the treatment group were administered with 150 m L of QZD twice a day,whereas those in the control group were given 1 g of levocarnitine oral liquid twice a day.The two groups received the indicated medication for 12 weeks and were then followed up for 4 weeks.The primary outcome was sperm motility,and the secondary therapeutic indices were sperm volume,density,pregnancy probability,and CM syndrome score.The comparison between groups was carried out at 4,8 and 12 weeks,respectively.The safety was determined before and after treatment.Results:(1)Drop-off:5 cases(7.58%)were lost after treatment(2 from the treatment group and 3 from the control group).(2)Primary outcomes:after 8-and 12-week treatment,the progressive sperms in the two groups were significantly higher than the baseline(all P<0.05);however,the treatment group showed greater improvement compared with the control group at 12-week treatment(22.7%±9.0%vs.14.1%±8.8%,P<0.05).The increasement of non-progressive grade sperms at both groups was observed at 8-and 12-week treatment with statistical difference(all P<0.05),however,the treatment group showed remarkable improvement compared with the control group at 12-week treatment(38.7%±14.1%vs.26.2%±15.4%,P<0.05).(3)Secondary outcomes:no significant statistical differences were found in semen volume and density(4,8,and 12-week treatment)and pregnancy probability of patients’wives(12-week treatment)between two groups(all P>0.05),however,the CM syndrome score of the treatment group significantly declined compared with baseline level at each time points(all P<0.05).(4)Safety:no obvious side reactions were found during the treatment in both groups.Conclusions:QZD could improve the progressive and non-progressive grade sperm in the treatment of idiopathic asthenozoospermia.It is safe with no obvious side effects.