Protective effect of anti-idiopathic pulmonary fibrosis drug Pirfenidone and Sufenidone(SC1011)on pulmonary injury induced by tuberculosis in a mouse tuberculosis model

Objective To evaluate the protective effect of antiidiopathic pulmonary fibrosis(IPF)marketed drug Pirfenidone and its clinical drug Sufenidone(SC1011)against lung injury in a mouse tuberculosis model.Methods C57BL/6 mouse model of tuberculosis was established.A total of 75 C57BL/6 mice were infected with 1×10^(7) CFU/ml H37Rv suspension by aerosol and randomly divided into untreated(n=9)group.

Comparison of interferon-gamma release assays and adenosine deaminase of pleural fluid for the diagnosis of pleural tuberculosis

Objective To compare the diagnostic performance of interferon gamma releasing assays(T-SPOT.TB)and adenosine deaminase(ADA)in pleural tuberculosis,and therefore to evaluate the value of T-SPOT.TB in a high tuberculosis burden country.Methods From June 2011to November 2012,111 patients with pleural fluid in Beijing Chest Hospital,Capital Medical University