A chronic ulcerative colitis model in rats

INTRODUCTIONIn recent years,there have been many reports aboutanimal model to investigate drugs for inflammatorybowel diseases (IBD).The experimental animalmodel often used is acetic acid-induced damage ofcolonic muscosa.In the present study,this animalmodel was investigated by administering variousconcentrations of TNBS.

Research of Helicobacter pylori infection in precancerous gastric lesions

INTRODUCTION Helicobacter pylori(Hp)infection has beenconsidered to play significant roles in pathogenesisof peptic ulcer.Additionally Hp is associated withthe development of gastric epithelial hyperplasiaand lymphoid malignancies.The InternationalAgency for Research on Cancer has classified lip asa class Ⅰ carcinogen and a definite cause of gastriccancer in humans.Hp infection first causes chronicactive gastritis and may slowly lead to infection ofwhole stomach.In the late stages of infection,mucosal atrophy and intestinal metaplasia(IM),

Effects of somatostatin on splanchnic hemodynamics in cirrhotic patients with portal hypertension

INTRODUCTIONEsophageal variceal bleeding (EVB) is one of themost common complications of cirrhosis with portalhypertension.In recent years,great progress hasbeen made in medicinal treatment.Somatostatin hasbeen widely used in clinics,for it can effectivelylower the portal venous pressure (PVP) with

A randomized,double-blind,placebo-controlled trial assessing the efficacy and safety of tegaserod in patients from China with chronic constipation

AIM: To evaluate the efficacy and safety of tegaserod, 6 mg twice daily (b.i.d.), in men and women with chronic constipation (CC) from China. METHODS: This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatment-free baseline period, patients were randomized to receive either tegaserod (6 mg b.i.d.) or placebo (b.i.d.) for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements (CSBMs) during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients’ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events (AEs).RESULTS: A total of 607 patients were randomized to receive either tegaserod (n = 304) or placebo (n = 303). Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo (1.39 vs 0.91, P = 0.0002). A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 (47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018) and for the absolute number of ≥ 3 CSBMs/wk over wk 1-4 (25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021). Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod (3.6%) compared with placebo (1.7%).CONCLUSION: Tegaserod treatment improved multiple symptoms of CC and was associated with a favorable safety profile.

EFFECT OF DENTIN TUBULES TO THE MECHANICAL PROPERTIES OF DENTIN.PART Ⅱ:EXPERIMENTAL STUDY

To verify the theoretical models of varying transversely isotropic stress-strain relations of dentin established in the preceding work(Part Ⅰ),we per- form a set of experiments.Because of the very fine tooth size,it usually seems to be difficult to directly measure the inhomogeneous and anisotropic parameters of dentin.In this paper,by the digital speckle correlation method,tensile experiments are made on the small dentin samples either parallel or perpendicular to the dentin tubules.With the theoretically predicted elastic stress-strain relations,an optimiza- tion method is proposed to fit the strain curve adapted to the experimental data. The results show that the theoretical elastic stress-strain relations coincides very well with the experimental observations.The determined Young's modulus and Poisson's ratio of dentin matrix are 29.5GPa and 0.44,respectively,in the optimization sense.

Metal 2-Hydroxy-1-Naphthaldehyde Thiosemicarbazone (Me-HNT) Complexes-A New Kind of Biomimic Enzyme Catalyst

Metal (Me=Fe(III), Mo(VI), Mn(II), Co(II), Ni(II), Zn(II) and Cu(II)) 2-hydroxy-1-naphthaldehyde thiosemicarbazone complexes (MeHNT) were synthesized and used as mimic-enzyme catalysts to mimic the active group of horseradish peroxidase (HRP). The results showed that Fe-HNT, Mo-HNT are effective catalysts, which have similar catalytic activity as HRP. The sequence of catalytic activities of tested biomimic peroxidas is Mo-HNT > Fe-HNT > Zn-HNT > Ni-HNT > Mn-HNT. Among them, Fe-HNT is used as a mimic-enzyme catalyst in determination of ascorbic acid and glucose by coupling the catalytic reaction of glucose oxidase.

Functional macrophages and gastrointestinal disorders

Macrophages(MΦ) differe ntiate from blood monocytes and participate in innate and adaptive immunity.Because of their abilities to recognize pathogens and activate bactericidal activities,MΦ are always discovered at the site of immune defense.MΦ in the intestine are unique,such that in the healthy intestine,they possess complex mechanisms to protect the gut from inflammation.In these complex mechanisms,they produce anti-inflammatory cytokines,such as interleukin-10 and transforming growth factor-β,and inhibit the inflammatory pathways mediated by Toll-like receptors.It has been demonstrated that resident MΦ play a crucial role in maintaining intestinal homeostasis,and they can be recognized by their unique markers.Nonetheless,in the inflamed intestine,the function of MΦ will change because of environmental variation,which may be one of the mechanisms of inflammatory bowel disease(IBD).We provide further explanation about these mechanisms in our review.In addition,we review recent discoveries that MΦ may be involved in the development of gastrointestinal tumors.We will highlight the possible therapeutic targets for the management of IBD and gastrointestinal tumors,and we also discuss why more details are needed to fully understand all other effects of intestinal MΦ.

TREATMENT OF PRIMARY TRIGEMINAL NEURALGIA WITH ACUPUNCTURE AT THE SPHENOPALATINE GANGLION

Twenty-five cases of Primary trigeminal neuralgia were treated satisfactorily by acupuncture at Xiaguan (St 7) through to the sphenopalatine ganglion, which is an important vegetative ganglion in the head.

Multivariate predictive model for asymptomatic spontaneous bacterial peritonitis in patients with liver cirrhosis

BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have successfully decreased themortality rate to 20%-25%. However, many patients cannot be diagnosed in theearly stages due to the absence of classical SBP symptoms. Early diagnosis ofasymptomatic SBP remains a great challenge in the clinic.AIMTo establish a multivariate predictive model for early diagnosis of asymptomaticSBP using positive microbial cultures from liver cirrhosis patients with ascites.METHODSA total of 98 asymptomatic SBP patients and 98 ascites liver cirrhosis patients withnegative microbial cultures were included in the case and control groups,respectively. Multiple linear stepwise regression analysis was performed toidentify potential indicators for asymptomatic SBP diagnosis. The diagnosticperformance of the model was estimated using the receiver operatingcharacteristic curve.RESULTSPatients in the case group were more likely to have advanced disease stages,cirrhosis related-complications, worsened hematology and ascites, and higher mortality. Based on multivariate analysis, the predictive model was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN(ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 ×HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The area under thecurve value of the established model was 0.872, revealing its high diagnosticpotential. The diagnostic sensitivity was 73.5% (72/98), the specificity was 86.7%(85/98), and the diagnostic efficacy was 80.1%.CONCLUSIONOur predictive model is based on the MELD score, polymorphonuclear cells,blood N, hepatocellular carcinoma, and renal dysfunction. This model mayimprove the early diagnosis of asymptomatic SBP.

夏枯草中的缩酚酸类化合物(英文)

从植物夏枯草 (PrunellavulgarisL .)的花穗中分离得到 2个新的 (1～ 2 )、3个已知的 (3～ 5 )缩酚酸类化合物和 2个苯丙素类化合物 ,通过光谱和化学分析确定其结构分别为迷迭香酸丁酯 (1)、顺式迷迭香酸丁酯 (2 )、迷迭香酸乙酯 (3)、迷迭香酸甲酯 (4)、迷迭香酸 (5 )、3,4 ,α 三羟基苯丙酸甲酯 (6 )和对香豆酸 (7)。

山蒟抗血小板活化因子作用的初步研究

本文以血小板活化因子(PAF)诱导的兔血小板聚集和实验动物炎症模型为指标观察了山蒟对PAF活性的影响。结果证明,山蒟醇提物不仅能明显抑制PAF诱导的兔血小板聚集,而且也能明显抑制PAF引起的炎症反应。山蒟醇提物对PAF性炎症的抑制作用不依赖肾上腺垂体系统的存在。

A CLINICAL STUDY ON THE EFFECT OF REINFORCEMENT OF KIDNEY ON SENILE BRAIN FUNCTIONS

In this study, Wu Zi Yan Zong ( 五子衍中WZYZ) fluid was used as the main recipe for reinforcement of the kidney. Six weeks after the therapy, the abilities of instantaneous memory and the memory of the segments of logical story were elevated, the time of upright standing with one leg and closure of the eye was prolonged, and the hand tremor and degree of kidney deficiency were unproved, but the memory width (memory in sequence and in reverse sequence of a figure) showed no significant difference in comparison with that before treatment.

LUNG DOSE DETERMINATION IN TOTAL BODY IRRADIATION PRIOR TO BONE MARROW TRANSPLANTATION

Total body irradiation (TBI) combined with chemotherapy prior to bone marrow transplantation (BMT) is used successfully for treatment leukemias. It need a high and homogeneous radiation dose to all target cells, dispersed In the whole body. The lung is the most sensitive vital organ at risk in TBI. The lung dose must be within it' s tolerable level. So, the determination of the lung dose is most Important for TBI. The determination of the lung dose is dependent on at least 8 parameters. In order to determine the effect of 8 parameters on the lung dose, using a system of phantom of Essen University hospital in F. R. Germany, a lot of measurements and a systematical investigation was made by varying 8 parameters, under the Essen translation TBI conditions. A analysis and discussion of results was made.

TREATMENT OF TONIC HEADACHE WITH ACUPUNCTURE

Tonic headache refers to headache in-duced by persistent muscular contractive ex-ertion in the neck and head,with corre-sponding abnormal arterial vasomotor func-tion,as a result of long-term anxiety,ten-sion and fatigue.During 1988-90 while inWest Germany on an academic exchangeprogram,Ⅰ treated 148 cases of headache,among whom 93 cases(63%)were of tonicnature.The results of treatment were good,as reported in the following:

215 CASES OF OBESITY TREATED WITH TCM MODALITIES

Cases of obesity are increasing in recentyears,especially in the cities.The mecha-nism ot obesity is the excessive accumulationof fat chiefly in the subcutaneous tissue dueto unnecessary intake of food calories thattransform into fat.The author adopted va-rious modalities for the treatment of 215cases of obesity with good results as re-ported in the following.

CLINICAL OBSERVATION ON NEEDLING EXTRACHANNEL POINTS IN TREATING MENTAL DEPRESSION

Totally 20 cases of mental depression were treated by needling extrachannel points with an effec-tive rate of 90%; comparison of these cases with 21 controls treated with amitriptyline, showed no significant difference in effect (P】0.05). Measured with Hamilton’s scale, factors of anxiety somatization, cognitive disturbance, retardation, sleep disturbance and feeling of despair in both the needling and control groups showed obvious decrease in the mean value, and the change in anxiety somatization was markedly significant in the needling group as compared with that in the controls (P【 0.01). Our studies revealed that after 6 weeks of needling the power of slow wave 5 decreased while that of the fast wave a increased, all significantly different as compared with that before and during the treatment (P 【 0.05).

EFFECT OF RADIX SALVIAE MILTIORRHIZAE EXTRACT INJECTION ON SURVIVAL OF ALLOGENEIC HEART TRANSPLANTATION

The effect of Radix Salviae Miltiorrhizae(RSM 丹参),a commonly used herbal blood cir-culation invigorator for the treatment of blood stasis(活血化瘀药)in traditional Chinesemedicine,on the duration of allograft survival following heterotopic heart transplantation inexperimental animals was observed.The results in three heart transplantation models—auricular free graft in mice,abdominal graft in rats and cervical graft in rabbits—suggestedthat RSM injection in an appropriate dosage prolonged the survival time of cardiacallograft.The herb showed no significant toxicity.It was also found that RSM injection hada synergic effect with corticosteroids against graft rejection.

ELECTROACUPUNCTURE TREATMENT OF PRESENILE AND SENILE DEPRESSIVE STATE

According to a survey in 1980,Chinahas an aging population of 80 million peopleover 60 years of age,which will increase to130 million toward the end of the presentcentury,making China a country with themost elderly people in the world.Due tothe lengthening of life expectancy

A SEQUENTIAL TESTING PROGRAM FOR PREDICTING AND IDENTIFICATING CARCINOGENS AND ITS APPLICATION

In this paper our studies about the sequential testing program for predicting and identificating carcinogens, sequential discriminant method and cost- effectiveness analysis are summarized. The analysis of our database of carcinogeniclty and genotoxicity of chemicals demonstrates the uncertainty . of short- term tests ( STTs ) to predict carcinogens and the results of most routine STTs are statistically dependent. We recommend the sequential testing program combining STTs and carclnogenicity assay, the optimal STT batteries, the rules of the sequential discrimination and the preferal choices of STTs tor specific chemical class. For illustrative pmposes the carclnogenicity prediction of several sample chamicals is presented. The results of cost-effectiveness analysis suggest that this program has vast social-economic effectiveness.

IMAGING TECHNIQUES FOR THE DIAGNOSIS OF RENAL TUMORS

In recent years.diagnostic imaging techniques,especially ultrasonography (US) and CTscanning,have been widely adopted in clinical practice,making early accurate diagnosisof renal tumors possible.A total of 452 cases of renal tumors have been admitted to theinstitute since 1951,of which 220 were seen from 1951 to 1979 and 232 in the past 9years (1980-1988).The frequency of renal parenchymal tumors was obviously higher in thelatter group,including asymptomatic renal carcinoma in 20.2% and hamartoma in 38.1%.All these were discovered on routine physical check-up by ultrasonography and/or CTscanning and would otherwise have gone undiagnosed on conventional urography.Ultra-sonography and CT can also reveal the nature and the extent of the tumor.The idea that“a renal tumor should be considered malignant unless pathologically proven otherwise”isno longer valid.However,general manifestations of renal carcinoma,such as elevatederythrocyte sedimentation rate (ESR),hypertension,malaise,anemia,fever and hypercalcemia,still deserve proper attention.We suggest that ultrasonography of both kidneys should bemandatory in routine physical check-up,as far as the urinary system is concerned,in orderto discover asymptomatic renal tumors.