Within the group of Roman brass tokens with numerals on the reverse, one type depicting a youthful commander on the obverse stands out. Obviously, it depicts a member of the Julio-Claudian dynasty. The young male is s...Within the group of Roman brass tokens with numerals on the reverse, one type depicting a youthful commander on the obverse stands out. Obviously, it depicts a member of the Julio-Claudian dynasty. The young male is seen from the back, holding a spear. The paper not only discusses this peculiar iconography but also tries to give a new identification: while the commander is usually identified with Tiberius or Germanicus, there are strong reasons to connect the portrait to Drusus minor.展开更多
Peanut allergy is majorly related to severe food induced allergic reactions.Several food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fis...Peanut allergy is majorly related to severe food induced allergic reactions.Several food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food allergies.Here,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and soybean.Additionally,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and dry-roasted.Using the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic response.The results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.展开更多
Fracture of the lateral process of the talus(FLPT)is uncommon in clinical practice and can be easily missed or misdiagnosed.In recent years,as researchers from all over the world have further deepened their research o...Fracture of the lateral process of the talus(FLPT)is uncommon in clinical practice and can be easily missed or misdiagnosed.In recent years,as researchers from all over the world have further deepened their research on FLPT,there has been a breakthrough in the classification,and the methods and principles of clinical management have changed accordingly;however,there is still no standardized guideline for the diagnosis and management of FLPT,and there have been few relevant literature review articles related to this kind of fracture in the past at least 5 years.In this article,we review the clinical classification,classification-based therapeutic recommendations,and prognosis of FLPT,with the aim of providing a reference for the clinical diagnosis and management of this infrequent fracture.展开更多
Objective:To assess the epidemiology of urinary schistosomiasis and soil-transmitted helminthiasis among women of reproductive age in Mwaluphamba,Kwale County,Kenya.Methods:A community-based cross-sectional study desi...Objective:To assess the epidemiology of urinary schistosomiasis and soil-transmitted helminthiasis among women of reproductive age in Mwaluphamba,Kwale County,Kenya.Methods:A community-based cross-sectional study design was employed to randomly sample 422 women of reproductive age(15-<50 years)from four villages in Mwaluphamba location.Stool specimens were collected and examined using the Kato-Katz method,while filtration technique was used to analyze urine specimens.Participants’sociodemographic details were obtained using a standardized questionnaire.Results:Urinary schistosomiasis prevalence was at 4.7%(20/422,95%CI 2.8%-6.9%)while the prevalence of soil-transmitted helminthiasis infection was 4.5%(19/422,95%CI 2.6%-6.7%).The infection intensities of urinary schistosomiasis among the study participants ranged from 1 to 120 eggs/10 mL of urine with median egg count of 18.45 eggs/10 mL.The patients were diagnosed with light infection,of 56.16 egg/gram and 48.48 egg/gram for Trichuris trichiura and hookworms,respectively.Women without latrines had 15.7 times higher risk of having urinary schistosomiasis compared to those with a latrine.Similarly,use of surface water(aOR=1.0,95%CI 0.2-1.4,P=0.010)and crossing the river to go to a place(aOR=1.1,95%CI 0.3-1.6,P=0.009)were statistically significant risk factors for getting urinary schistosomiasis.In bivariable regression analysis,defecating around the water source(OR=4.3,95%CI 1.5-12.9)had a statistically significant association with the prevalence of soil-transmitted helminthiasis(P=0.008).Conclusions:This study has given an insight on the prevalence and intensity of urinary schistosomiasis and soil-transmitted helminthiasis in Mwaluphamba location that form a basis for strengthening the control and elimination programmes for these neglected tropical diseases.展开更多
Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for societies.By using network analysis,the present study managed to identify significant nearly-simultaneous occurren...Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for societies.By using network analysis,the present study managed to identify significant nearly-simultaneous occurrences of heatwaves between the grid cells in East Asia and Eastern Europe,even though they are geographically far away from each other.By further composite analysis,this study revealed that hot events first occurred in Eastern Europe,typically with a time lag of3-4 days before the East Asian heatwave events.An eastward propagating atmospheric wave train,known as the circumglobal teleconnection(CGT)pattern,bridged the sequent occurrences of extreme events in these two remote regions.Atmospheric blockings,amplified by surface warming over Eastern Europe,not only enhanced local heat extremes but also excited a CGT-like pattern characterized by alternative anomalies of high and low pressures.Subsequent downstream anticyclones in the middle and upper troposphere reduced local cloud cover and increased downward solar radiation,thereby facilitating the formation of heatwaves over East Asia.Nearly half of East Asian heatwave events were preceded by Eastern European heatwave events in the 10-day time range before East Asian heatwave events.This investigation of heatwave teleconnection in the two distant regions exhibits strong potential to improve the prediction accuracy of East Asian heatwaves.展开更多
This paper describes a new numerical QCD calculation method (direct minimization of QCD-QED-action) and its results for the first-generation (u, d) hadrons. Here we start with the standard color-Lagrangian LQCD = LDir...This paper describes a new numerical QCD calculation method (direct minimization of QCD-QED-action) and its results for the first-generation (u, d) hadrons. Here we start with the standard color-Lagrangian LQCD = LDirac + Lgluon, model the quarks q<sub>i</sub> as parameterized gaussians, and the gluons Ag<sub>i</sub> as Ritz-Galerkin-series. We minimize the Lagrangian numerically with parameters par = (par (q), {α<sub>k</sub>}, par (Ag)) for first-generation hadrons (nucleons, pseudo-scalar mesons, vector mesons). The resulting parameters yield the correct masses and correct magnetic moments for the nucleons, the gluon-distribution and the quark-distribution with interesting insights into the hadron structure.展开更多
The Pythagorean triples (a, b | c) of planar geometry which satisfy the equation a<sup>2</sup>+b<sup>2</sup>=c<sup>2</sup> with integers (a, b, c) are generalized to 3D-Pythagorean ...The Pythagorean triples (a, b | c) of planar geometry which satisfy the equation a<sup>2</sup>+b<sup>2</sup>=c<sup>2</sup> with integers (a, b, c) are generalized to 3D-Pythagorean quadruples (a, b, c | d) of spatial geometry which satisfy the equation a<sup>2</sup>+b<sup>2</sup>+c<sup>2</sup>=d<sup>2</sup> with integers (a, b, c, d). Rules for a parametrization of the numbers (a, b, c, d) are derived and a list of all possible nonequivalent cases without common divisors up to d<sup>2</sup> is established. The 3D-Pythagorean quadruples are then generalized to 4D-Pythagorean quintuples (a, b, c, d | e) which satisfy the equation a<sup>2</sup>+b<sup>2</sup>+c<sup>2</sup>+d<sup>2</sup>=e<sup>2</sup> and a parametrization is derived. Relations to the 4-square identity are discussed which leads also to the N-dimensional case. The initial 3D- and 4D-Pythagorean numbers are explicitly calculated up to d<sup>2</sup>, respectively, e<sup>2</sup>.展开更多
Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body environment.This necessitates the synthesis of a suitable coating that may improve ...Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body environment.This necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical integrity.In this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite coating.Detailed analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.展开更多
This paper presents a new theory of gravity, called here Ashtekar-Kodama (AK) gravity, which is based on the Ashtekar-Kodama formulation of loop quantum gravity (LQG), yields in the limit the Einstein equations, and i...This paper presents a new theory of gravity, called here Ashtekar-Kodama (AK) gravity, which is based on the Ashtekar-Kodama formulation of loop quantum gravity (LQG), yields in the limit the Einstein equations, and in the quantum regime a full renormalizable quantum gauge field theory. The three fundamental constraints (hamiltonian, gaussian and diffeomorphism) were formulated in 3-dimensional spatial form within LQG in Ashtekar formulation using the notion of the Kodama state with positive cosmological constant Λ. We introduce a 4-dimensional covariant version of the 3-dimensional (spatial) hamiltonian, gaussian and diffeomorphism constraints of LQG. We obtain 32 partial differential equations for the 16 variables E<sub>mn</sub> (E-tensor, inverse densitized tetrad of the metric) and 16 variables A<sub>mn</sub> (A-tensor, gravitational wave tensor). We impose the boundary condition: for large distance the E-generated metric g(E) becomes the GR-metric g (normally Schwarzschild-spacetime). The theory based on these Ashtekar-Kodama (AK) equations, and called in the following Ashtekar-Kodama (AK-) gravity has the following properties. • For Λ = 0 the AK equations become Einstein equations, A-tensor is trivial (constant), and the E-generated metric g(E) is identical with the GR-metric g. • When the AK-equations are developed into a Λ-power series, the Λ-term yields a gravitational wave equation, which has only at least quadrupole wave solutions and becomes in the limit of large distance r the (normal electromagnetic) wave equation. • AK-gravity, as opposed to GR, has no singularity at the horizon: the singularity in the metric becomes a (very high) peak. • AK-gravity has a limit scale of the gravitational quantum region 39 μm, which emerges as the limit scale in the objective wave collapse theory of Gherardi-Rimini-Weber. In the quantum region, the AK-gravity becomes a quantum gauge theory (AK quantum gravity) with the Lie group extended SU(2) = ε-tensor-group(four generators) as gauge group and a corresponding covariant derivative. • AK quantum gravity is fully renormalizable, we derive its Lagrangian, which is dimensionally renormalizable, the normalized one-graviton wave function, the graviton propagator, and demonstrate the calculation of cross-section from Feynman diagrams.展开更多
This article gives a state-of-the-art description of the cosmological Lambda-CDM model and in addition, presents extensions of the model with new calculations of background and CMB functions. Chapters 1-4 describe the...This article gives a state-of-the-art description of the cosmological Lambda-CDM model and in addition, presents extensions of the model with new calculations of background and CMB functions. Chapters 1-4 describe the background part of the model, i.e. the evolution of scale factor and density according to the Friedmann equations, and its extension, which results in a correction of the Hubble parameter, in agreement with new measurements (Cepheids-SNIa and Red-Giants). Based on this improved background calculation presented in chapters 5-9 the perturbation part of the model, i.e. the evolution of perturbation and structure according to the perturbed Einstein equations and continuity-Euler equations, and the power spectrum of the cosmic microwave background (CMB) is calculated with a new own code.展开更多
This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the S...This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.展开更多
文摘Within the group of Roman brass tokens with numerals on the reverse, one type depicting a youthful commander on the obverse stands out. Obviously, it depicts a member of the Julio-Claudian dynasty. The young male is seen from the back, holding a spear. The paper not only discusses this peculiar iconography but also tries to give a new identification: while the commander is usually identified with Tiberius or Germanicus, there are strong reasons to connect the portrait to Drusus minor.
文摘Peanut allergy is majorly related to severe food induced allergic reactions.Several food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food allergies.Here,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and soybean.Additionally,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and dry-roasted.Using the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic response.The results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.
基金Supported by The China Scholarship Council,No.202308420035.
文摘Fracture of the lateral process of the talus(FLPT)is uncommon in clinical practice and can be easily missed or misdiagnosed.In recent years,as researchers from all over the world have further deepened their research on FLPT,there has been a breakthrough in the classification,and the methods and principles of clinical management have changed accordingly;however,there is still no standardized guideline for the diagnosis and management of FLPT,and there have been few relevant literature review articles related to this kind of fracture in the past at least 5 years.In this article,we review the clinical classification,classification-based therapeutic recommendations,and prognosis of FLPT,with the aim of providing a reference for the clinical diagnosis and management of this infrequent fracture.
文摘Objective:To assess the epidemiology of urinary schistosomiasis and soil-transmitted helminthiasis among women of reproductive age in Mwaluphamba,Kwale County,Kenya.Methods:A community-based cross-sectional study design was employed to randomly sample 422 women of reproductive age(15-<50 years)from four villages in Mwaluphamba location.Stool specimens were collected and examined using the Kato-Katz method,while filtration technique was used to analyze urine specimens.Participants’sociodemographic details were obtained using a standardized questionnaire.Results:Urinary schistosomiasis prevalence was at 4.7%(20/422,95%CI 2.8%-6.9%)while the prevalence of soil-transmitted helminthiasis infection was 4.5%(19/422,95%CI 2.6%-6.7%).The infection intensities of urinary schistosomiasis among the study participants ranged from 1 to 120 eggs/10 mL of urine with median egg count of 18.45 eggs/10 mL.The patients were diagnosed with light infection,of 56.16 egg/gram and 48.48 egg/gram for Trichuris trichiura and hookworms,respectively.Women without latrines had 15.7 times higher risk of having urinary schistosomiasis compared to those with a latrine.Similarly,use of surface water(aOR=1.0,95%CI 0.2-1.4,P=0.010)and crossing the river to go to a place(aOR=1.1,95%CI 0.3-1.6,P=0.009)were statistically significant risk factors for getting urinary schistosomiasis.In bivariable regression analysis,defecating around the water source(OR=4.3,95%CI 1.5-12.9)had a statistically significant association with the prevalence of soil-transmitted helminthiasis(P=0.008).Conclusions:This study has given an insight on the prevalence and intensity of urinary schistosomiasis and soil-transmitted helminthiasis in Mwaluphamba location that form a basis for strengthening the control and elimination programmes for these neglected tropical diseases.
基金Guangdong Major Project of Basic and Applied Basic Research (2020B0301030004)National Natural Science Foundation of China (42275020)+1 种基金Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (311021001)Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies (2020B1212060025)。
文摘Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for societies.By using network analysis,the present study managed to identify significant nearly-simultaneous occurrences of heatwaves between the grid cells in East Asia and Eastern Europe,even though they are geographically far away from each other.By further composite analysis,this study revealed that hot events first occurred in Eastern Europe,typically with a time lag of3-4 days before the East Asian heatwave events.An eastward propagating atmospheric wave train,known as the circumglobal teleconnection(CGT)pattern,bridged the sequent occurrences of extreme events in these two remote regions.Atmospheric blockings,amplified by surface warming over Eastern Europe,not only enhanced local heat extremes but also excited a CGT-like pattern characterized by alternative anomalies of high and low pressures.Subsequent downstream anticyclones in the middle and upper troposphere reduced local cloud cover and increased downward solar radiation,thereby facilitating the formation of heatwaves over East Asia.Nearly half of East Asian heatwave events were preceded by Eastern European heatwave events in the 10-day time range before East Asian heatwave events.This investigation of heatwave teleconnection in the two distant regions exhibits strong potential to improve the prediction accuracy of East Asian heatwaves.
文摘This paper describes a new numerical QCD calculation method (direct minimization of QCD-QED-action) and its results for the first-generation (u, d) hadrons. Here we start with the standard color-Lagrangian LQCD = LDirac + Lgluon, model the quarks q<sub>i</sub> as parameterized gaussians, and the gluons Ag<sub>i</sub> as Ritz-Galerkin-series. We minimize the Lagrangian numerically with parameters par = (par (q), {α<sub>k</sub>}, par (Ag)) for first-generation hadrons (nucleons, pseudo-scalar mesons, vector mesons). The resulting parameters yield the correct masses and correct magnetic moments for the nucleons, the gluon-distribution and the quark-distribution with interesting insights into the hadron structure.
文摘The Pythagorean triples (a, b | c) of planar geometry which satisfy the equation a<sup>2</sup>+b<sup>2</sup>=c<sup>2</sup> with integers (a, b, c) are generalized to 3D-Pythagorean quadruples (a, b, c | d) of spatial geometry which satisfy the equation a<sup>2</sup>+b<sup>2</sup>+c<sup>2</sup>=d<sup>2</sup> with integers (a, b, c, d). Rules for a parametrization of the numbers (a, b, c, d) are derived and a list of all possible nonequivalent cases without common divisors up to d<sup>2</sup> is established. The 3D-Pythagorean quadruples are then generalized to 4D-Pythagorean quintuples (a, b, c, d | e) which satisfy the equation a<sup>2</sup>+b<sup>2</sup>+c<sup>2</sup>+d<sup>2</sup>=e<sup>2</sup> and a parametrization is derived. Relations to the 4-square identity are discussed which leads also to the N-dimensional case. The initial 3D- and 4D-Pythagorean numbers are explicitly calculated up to d<sup>2</sup>, respectively, e<sup>2</sup>.
文摘Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body environment.This necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical integrity.In this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite coating.Detailed analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.
文摘This paper presents a new theory of gravity, called here Ashtekar-Kodama (AK) gravity, which is based on the Ashtekar-Kodama formulation of loop quantum gravity (LQG), yields in the limit the Einstein equations, and in the quantum regime a full renormalizable quantum gauge field theory. The three fundamental constraints (hamiltonian, gaussian and diffeomorphism) were formulated in 3-dimensional spatial form within LQG in Ashtekar formulation using the notion of the Kodama state with positive cosmological constant Λ. We introduce a 4-dimensional covariant version of the 3-dimensional (spatial) hamiltonian, gaussian and diffeomorphism constraints of LQG. We obtain 32 partial differential equations for the 16 variables E<sub>mn</sub> (E-tensor, inverse densitized tetrad of the metric) and 16 variables A<sub>mn</sub> (A-tensor, gravitational wave tensor). We impose the boundary condition: for large distance the E-generated metric g(E) becomes the GR-metric g (normally Schwarzschild-spacetime). The theory based on these Ashtekar-Kodama (AK) equations, and called in the following Ashtekar-Kodama (AK-) gravity has the following properties. • For Λ = 0 the AK equations become Einstein equations, A-tensor is trivial (constant), and the E-generated metric g(E) is identical with the GR-metric g. • When the AK-equations are developed into a Λ-power series, the Λ-term yields a gravitational wave equation, which has only at least quadrupole wave solutions and becomes in the limit of large distance r the (normal electromagnetic) wave equation. • AK-gravity, as opposed to GR, has no singularity at the horizon: the singularity in the metric becomes a (very high) peak. • AK-gravity has a limit scale of the gravitational quantum region 39 μm, which emerges as the limit scale in the objective wave collapse theory of Gherardi-Rimini-Weber. In the quantum region, the AK-gravity becomes a quantum gauge theory (AK quantum gravity) with the Lie group extended SU(2) = ε-tensor-group(four generators) as gauge group and a corresponding covariant derivative. • AK quantum gravity is fully renormalizable, we derive its Lagrangian, which is dimensionally renormalizable, the normalized one-graviton wave function, the graviton propagator, and demonstrate the calculation of cross-section from Feynman diagrams.
文摘This article gives a state-of-the-art description of the cosmological Lambda-CDM model and in addition, presents extensions of the model with new calculations of background and CMB functions. Chapters 1-4 describe the background part of the model, i.e. the evolution of scale factor and density according to the Friedmann equations, and its extension, which results in a correction of the Hubble parameter, in agreement with new measurements (Cepheids-SNIa and Red-Giants). Based on this improved background calculation presented in chapters 5-9 the perturbation part of the model, i.e. the evolution of perturbation and structure according to the perturbed Einstein equations and continuity-Euler equations, and the power spectrum of the cosmic microwave background (CMB) is calculated with a new own code.
文摘This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.