In three recent articles published in Nature and Cell,Weatherbee et al.1,Pedroza et al.2 and Liu et al.3 have demonstrated how human pluripotent stem cells can be coaxed to self-organize into compartmentalized structu...In three recent articles published in Nature and Cell,Weatherbee et al.1,Pedroza et al.2 and Liu et al.3 have demonstrated how human pluripotent stem cells can be coaxed to self-organize into compartmentalized structures that mirror post-implantation embryos.Building on the successful establishment of stem cell-derived mouse embryo models ex utero,these models now shed light on human embryo development during the period between implantation and gastrulation,which has so far been challenging to investigate.展开更多
基金supported by the DFG Emmy Noether Grant to M.S.(Si-1983/4-1)the ERC Starting Grant(REVERT)to M.S.,the Einstein Foundation grant with in the EC3R initiative to M.S.and BMBF Grant 01EJ2206A(PACETherapy)to M.S.
文摘In three recent articles published in Nature and Cell,Weatherbee et al.1,Pedroza et al.2 and Liu et al.3 have demonstrated how human pluripotent stem cells can be coaxed to self-organize into compartmentalized structures that mirror post-implantation embryos.Building on the successful establishment of stem cell-derived mouse embryo models ex utero,these models now shed light on human embryo development during the period between implantation and gastrulation,which has so far been challenging to investigate.
