CD4^(+)CD25^(+)FOXP3^(+)regulatory T cells(Tregs)contribute to the maintenance of immune homeostasis and tolerance in the body.The expression levels and functional stability of FOXP3 control the function and plasticit...CD4^(+)CD25^(+)FOXP3^(+)regulatory T cells(Tregs)contribute to the maintenance of immune homeostasis and tolerance in the body.The expression levels and functional stability of FOXP3 control the function and plasticity of Tregs.Tregs critically impact infectious diseases,especially by regulating the threshold of immune responses to pathogenic microorganisms.The functional regulatory mechanism and cell-specific surface markers of Tregs in different tissues and inflammatory microenvironments have been investigated in depth,which can provide novel ideas and strategies for immunotherapies targeting infectious diseases.展开更多
基金This work was supported by the National Natural Science Foundation of China(81971881,81830051,31670911,and 31961133011)Innovative research team of high-level local universities in Shanghai SSMU-ZDCX20180101,Shanghai Jiao Tong University(SJTU)+1 种基金the Chinese University of Hong Kong(CUHK)Joint Research Collaboration Fund and the Fundamental Research Funds for Central UniversitiesScientific and technological innovation talents in Colleges and universities of Henan Province(19HASTIT003).
文摘CD4^(+)CD25^(+)FOXP3^(+)regulatory T cells(Tregs)contribute to the maintenance of immune homeostasis and tolerance in the body.The expression levels and functional stability of FOXP3 control the function and plasticity of Tregs.Tregs critically impact infectious diseases,especially by regulating the threshold of immune responses to pathogenic microorganisms.The functional regulatory mechanism and cell-specific surface markers of Tregs in different tissues and inflammatory microenvironments have been investigated in depth,which can provide novel ideas and strategies for immunotherapies targeting infectious diseases.
