The capture and transformation of the greenhouse gas CO_(2) into high-value products is currently of paramount importance worldwide,with many different approaches being conceived and tested[1-6].The transformation CO_...The capture and transformation of the greenhouse gas CO_(2) into high-value products is currently of paramount importance worldwide,with many different approaches being conceived and tested[1-6].The transformation CO_(2) into carbohydrates is a particularly intriguing idea,but putting it into reality is challenging due to the necessary complete control in the creation of stereo-centers and ensuring sufficient yields.Thus far,the results are not overly convincing[7].The inspiration for solving this fundamental problem is manifold,inter alia,because carbohydrates(sugars)contribute significantly to energy storage and provide carriers for human living,especially important biologically active substances.They also constitute the main resource for industrial biomanufacturing.展开更多
This review article critically compares two widely used types of catalysis,chemo-and biocatalysis,and provides insights on their greenness according to specified parameters.A comparative analysis of the environmental ...This review article critically compares two widely used types of catalysis,chemo-and biocatalysis,and provides insights on their greenness according to specified parameters.A comparative analysis of the environmental impact of chemo-and biocatalytic oxyfunctionalisation reactions based on published experimental data reveals that both methods produce comparable amounts of waste,with the majority stemming from the solvent used.However,it is emphasised that the synthesis of the catalysts themselves,including biocatalysts,should also be considered when assessing their environmental impact.The review underscores the complexity of assessing the environmental impact of catalytic oxyfunctionalisation reactions.The article also discusses the relationship between solvent properties and the energy demands for chemical transformations and downstream processing,underlining that the choice of solvent can significantly influence the environmental impact of a catalytic process.Additionally,the review highlights the importance of considering the recyclability of reagents and the secondary CO_(2)emissions caused by the energy requirements of the reaction when evaluating the environmental impact of a catalytic process.Each chemo-and biocatalysis produce a certain environmental impact,the greenness of either method is dependent on several factors,including the type of waste generated,the recyclability of reagents,and secondary CO_(2)emissions.This review therefore recommends using consistent metrics and a comprehensive life cycle assessment approach to evaluate this environmental impact,and highlights the importance of considering the synthesis of the catalysts themselves.展开更多
This book[1]begins with an introductory chapter in which the history of directed enzyme evolution is briefly presented and the different gene mutagenesis techniques are outlined,followed by a comprehensive chapter des...This book[1]begins with an introductory chapter in which the history of directed enzyme evolution is briefly presented and the different gene mutagenesis techniques are outlined,followed by a comprehensive chapter describing medium-and high-throughput screening systems for assaying stereoselectivity and activity.展开更多
文摘The capture and transformation of the greenhouse gas CO_(2) into high-value products is currently of paramount importance worldwide,with many different approaches being conceived and tested[1-6].The transformation CO_(2) into carbohydrates is a particularly intriguing idea,but putting it into reality is challenging due to the necessary complete control in the creation of stereo-centers and ensuring sufficient yields.Thus far,the results are not overly convincing[7].The inspiration for solving this fundamental problem is manifold,inter alia,because carbohydrates(sugars)contribute significantly to energy storage and provide carriers for human living,especially important biologically active substances.They also constitute the main resource for industrial biomanufacturing.
基金Funded by the European Union(ERC,PeroxyZyme,No101054658).
文摘This review article critically compares two widely used types of catalysis,chemo-and biocatalysis,and provides insights on their greenness according to specified parameters.A comparative analysis of the environmental impact of chemo-and biocatalytic oxyfunctionalisation reactions based on published experimental data reveals that both methods produce comparable amounts of waste,with the majority stemming from the solvent used.However,it is emphasised that the synthesis of the catalysts themselves,including biocatalysts,should also be considered when assessing their environmental impact.The review underscores the complexity of assessing the environmental impact of catalytic oxyfunctionalisation reactions.The article also discusses the relationship between solvent properties and the energy demands for chemical transformations and downstream processing,underlining that the choice of solvent can significantly influence the environmental impact of a catalytic process.Additionally,the review highlights the importance of considering the recyclability of reagents and the secondary CO_(2)emissions caused by the energy requirements of the reaction when evaluating the environmental impact of a catalytic process.Each chemo-and biocatalysis produce a certain environmental impact,the greenness of either method is dependent on several factors,including the type of waste generated,the recyclability of reagents,and secondary CO_(2)emissions.This review therefore recommends using consistent metrics and a comprehensive life cycle assessment approach to evaluate this environmental impact,and highlights the importance of considering the synthesis of the catalysts themselves.
文摘This book[1]begins with an introductory chapter in which the history of directed enzyme evolution is briefly presented and the different gene mutagenesis techniques are outlined,followed by a comprehensive chapter describing medium-and high-throughput screening systems for assaying stereoselectivity and activity.
