Fermented soy foods(FSFs)are consumed as a common staple in many countries of Asia.They are receiving cosmopolitan demand because of their impressive functional properties.FSFs comprise numerous bioactive components a...Fermented soy foods(FSFs)are consumed as a common staple in many countries of Asia.They are receiving cosmopolitan demand because of their impressive functional properties.FSFs comprise numerous bioactive components and phytochemicals with multiple health benefits besides valuable nutrients.Research suggests that use of FSFs are more beneficial than their non-fermented forms because of their higher digestibility,functional components,good probiotic content and lower amount of anti-nutritional factors.Interestingly,a large body of evidence signifies antidiabetic properties of FSFs.A plethora of in vitro,in vivo and clinical experiments revealed that FSFs prepared either through traditional or standardized methods could be operative against hyperglycemia,insulin resistance,aberrant energy metabolism,oxidative stress and low-grade inflammation associated with diabetic pathophysiology.The antidiabetic efficacies of FSFs were attributed to various functional ingredients including bioactive peptides,isoflavones,polyphenols,and vitamins.The collective molecular insights in support of antidiabetic actions of FSFs and their derivative components unraveled a wide range of pharmacological targets,such as carbohydrate/lipid hydrolyzing enzymes,cell signaling molecules,transcription factors,and cell-surface transporters in multiple organ-system.The present review aims to summarize and systematically represent the antidiabetic potency of various fermentation-based soy foods including fermented soy paste,sauce,milk,condiment,permeate according to the interpretations from in vitro,pre-clinical and clinical data.Additionally,the pleotropic roles of biofactors underlying the anti-hyperglycemic potential of FSFs are deciphered in the present piece of work.Such cumulative representation along with current opinions and future perspectives could be helpful for the emergence of food-based therapeutics.展开更多
Non-alcoholic fatty liver disease(NAFLD)includes a broad spectrum of liver dysfunction ranging from hepatic steatosis(intracellular triglyceride accumulation)to steatohepatitis.This study investigated the beneficial e...Non-alcoholic fatty liver disease(NAFLD)includes a broad spectrum of liver dysfunction ranging from hepatic steatosis(intracellular triglyceride accumulation)to steatohepatitis.This study investigated the beneficial effect of Premna herbacea(a dietary leafy vegetable of North East India)and its active constituent in managing hepatic steatosis using high fat diet(HFD)-fed male Wistar rat and hepatocyte(CC1)cell culture models.Administration with methanolic leaf extract of Premna herbacea(PHME)(250 mg/kg body weight,oral gavage,20 weeks)reduced the gain in body weight and rise in serum lipid(triglyceride and total cholesterol)levels and enzymes(alkaline phosphatase and aspartate aminotransferase)responsible for liver dysfunction in high fat diet(HFD)-fed rats.PHME administration further upregulated the phosphorylation of AMPK,ACC,and HMGCR,downregulated SREBP1 signaling pathways of lipid metabolism,and prevented hepatic steatosis in liver tissues of HFD-fed rats.Moreover,studies on cultured hepatocytes revealed that treatment with both crude extract and its ethyl acetate fraction(PHEA)significantly reduced intracellular lipid accumulation in palmitate(PA,0.75 mM)-treated cells.Chemical profiling(HPLC,HRMS,^(1)H and^(13)C NMR)of PHEA demonstrated the presence of Verbascoside,a caffeoyl phenylethanoid glycoside as a major phyto-constituent,which prevented cellular lipid accumulation and regulated the alteration in AMPK/SREBP/ACC/HMGCR signaling pathways of lipid metabolism in PA-treated cells.In conclusion,this study showed the prophylactic role of Premna herbacea and its active molecule,Verbascoside as a potential functional food in ameliorating hepatic steatosis by regulating AMPK/SREBP/ACC/HMGCR signaling cascade.展开更多
基金CSIR-HRDG,India,for providing the Senior Research Fellowship to Mr.Dibyendu Das(18/12/2016(ii)EU-V dtd 01-07-2017&Sr.No.1121630992).
文摘Fermented soy foods(FSFs)are consumed as a common staple in many countries of Asia.They are receiving cosmopolitan demand because of their impressive functional properties.FSFs comprise numerous bioactive components and phytochemicals with multiple health benefits besides valuable nutrients.Research suggests that use of FSFs are more beneficial than their non-fermented forms because of their higher digestibility,functional components,good probiotic content and lower amount of anti-nutritional factors.Interestingly,a large body of evidence signifies antidiabetic properties of FSFs.A plethora of in vitro,in vivo and clinical experiments revealed that FSFs prepared either through traditional or standardized methods could be operative against hyperglycemia,insulin resistance,aberrant energy metabolism,oxidative stress and low-grade inflammation associated with diabetic pathophysiology.The antidiabetic efficacies of FSFs were attributed to various functional ingredients including bioactive peptides,isoflavones,polyphenols,and vitamins.The collective molecular insights in support of antidiabetic actions of FSFs and their derivative components unraveled a wide range of pharmacological targets,such as carbohydrate/lipid hydrolyzing enzymes,cell signaling molecules,transcription factors,and cell-surface transporters in multiple organ-system.The present review aims to summarize and systematically represent the antidiabetic potency of various fermentation-based soy foods including fermented soy paste,sauce,milk,condiment,permeate according to the interpretations from in vitro,pre-clinical and clinical data.Additionally,the pleotropic roles of biofactors underlying the anti-hyperglycemic potential of FSFs are deciphered in the present piece of work.Such cumulative representation along with current opinions and future perspectives could be helpful for the emergence of food-based therapeutics.
文摘Non-alcoholic fatty liver disease(NAFLD)includes a broad spectrum of liver dysfunction ranging from hepatic steatosis(intracellular triglyceride accumulation)to steatohepatitis.This study investigated the beneficial effect of Premna herbacea(a dietary leafy vegetable of North East India)and its active constituent in managing hepatic steatosis using high fat diet(HFD)-fed male Wistar rat and hepatocyte(CC1)cell culture models.Administration with methanolic leaf extract of Premna herbacea(PHME)(250 mg/kg body weight,oral gavage,20 weeks)reduced the gain in body weight and rise in serum lipid(triglyceride and total cholesterol)levels and enzymes(alkaline phosphatase and aspartate aminotransferase)responsible for liver dysfunction in high fat diet(HFD)-fed rats.PHME administration further upregulated the phosphorylation of AMPK,ACC,and HMGCR,downregulated SREBP1 signaling pathways of lipid metabolism,and prevented hepatic steatosis in liver tissues of HFD-fed rats.Moreover,studies on cultured hepatocytes revealed that treatment with both crude extract and its ethyl acetate fraction(PHEA)significantly reduced intracellular lipid accumulation in palmitate(PA,0.75 mM)-treated cells.Chemical profiling(HPLC,HRMS,^(1)H and^(13)C NMR)of PHEA demonstrated the presence of Verbascoside,a caffeoyl phenylethanoid glycoside as a major phyto-constituent,which prevented cellular lipid accumulation and regulated the alteration in AMPK/SREBP/ACC/HMGCR signaling pathways of lipid metabolism in PA-treated cells.In conclusion,this study showed the prophylactic role of Premna herbacea and its active molecule,Verbascoside as a potential functional food in ameliorating hepatic steatosis by regulating AMPK/SREBP/ACC/HMGCR signaling cascade.