Methyl 9 ethylenedioxpyropheophorbide d was prepared from methyl pyropheophorbide a by protection of cyclic ketone with ethylene glycol, and oxidation with OsO 4 in vinyl group at 2 position. The terminal alky...Methyl 9 ethylenedioxpyropheophorbide d was prepared from methyl pyropheophorbide a by protection of cyclic ketone with ethylene glycol, and oxidation with OsO 4 in vinyl group at 2 position. The terminal alkyne was introduced into chlorin chromophore by Grignard reaction, and the enediyne moiety was constructed by a palladium catalyzed coupling reaction with (Z) chloroenynes.展开更多
文摘Methyl 9 ethylenedioxpyropheophorbide d was prepared from methyl pyropheophorbide a by protection of cyclic ketone with ethylene glycol, and oxidation with OsO 4 in vinyl group at 2 position. The terminal alkyne was introduced into chlorin chromophore by Grignard reaction, and the enediyne moiety was constructed by a palladium catalyzed coupling reaction with (Z) chloroenynes.
