期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Tuberculosis-diabetes comorbidities: Mechanistic insights for clinical considerations and treatment challenges
1
作者 Md Abdul Alim Al-Bari Nicholas Peake Nabil Eid 《World Journal of Diabetes》 SCIE 2024年第5期853-866,共14页
Tuberculosis(TB)remains a leading cause of death among infectious diseases,particularly in poor countries.Viral infections,multidrug-resistant and ex-tensively drug-resistant TB strains,as well as the coexistence of c... Tuberculosis(TB)remains a leading cause of death among infectious diseases,particularly in poor countries.Viral infections,multidrug-resistant and ex-tensively drug-resistant TB strains,as well as the coexistence of chronic illnesses such as diabetes mellitus(DM)greatly aggravate TB morbidity and mortality.DM[particularly type 2 DM(T2DM)]and TB have converged making their control even more challenging.Two contemporary global epidemics,TB-DM behaves like a syndemic,a synergistic confluence of two highly prevalent diseases.T2DM is a risk factor for developing more severe forms of multi-drug resistant-TB and TB recurrence after preventive treatment.Since a bidirectional relationship exists between TB and DM,it is necessary to concurrently treat both,and promote recommendations for the joint management of both diseases.There are also some drug-drug interactions resulting in adverse treatment outcomes in TB-DM patients including treatment failure,and reinfection.In addition,autophagy may play a role in these comorbidities.Therefore,the TB-DM comorbidities present several health challenges,requiring a focus on multidisciplinary collaboration and integrated strategies,to effectively deal with this double burden.To effectively manage the comorbidity,further screening in affected countries,more suitable drugs,and better treatment strategies are required. 展开更多
关键词 Diabetes mellitus TUBERCULOSIS Coinfections COMORBIDITY Drug-drug interactions Autophagy Treatment challenges
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部