SARS and its treatment strategies

This paper briefly review severe acute respiratory syndrome, a devastating disease which broke out 15 years ago, and its treatment strategies. With the newly discovered SARSr-CoV strain in Yunnan, China, and the help of new technologies such as RNA interference, DNA vaccines, CRISPR technology and base editing, and intervention of RT-ABCDEF(iRT-ABCDEF), a standardized comprehensive program, people can better fight severe acute respiratory syndrome and other major virus-communicable diseases like highly pathogenic avian influenza and dengue fever with these powerful tools in the future.

SEEDi^(1.0-3.0) strategies for major noncommunicable diseases in China

The purpose of this article is to briefly introduce the status and challenges of major noncommunicable diseases （mNCDs）, which include cardiovascular disease, diabetes and cancer, as well as related risk factors, such as environmental pollution, smoking, obesity and sleep disorders. ＂S-E-E-D＂ rules or the strategies of ＂S-E-E-D＂ intervention （SEEDi） consist of four core healthy elements： sleep, emotion, exercise and diet. The history of SEEDi1.0-3.0 is also introduced, which includes versions 1.0, 1.5, 2.0 and 3.0 of the program. These guidelines are suitable for prevention and control of mNCDs. Not only the ＂Healthy China＂ initiated in China＇s ＂13th Five-year Plan,＂ but also the ＂Healthy World＂ philosophy needs SEEDi1.0-3.0 strategies for control of mNCDs.

Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come

Chronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes administration of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and aldosterone antagonists, to biomedical engineering methods, which include interventional engineering, such as percutaneous balloon mitral valvotomy, percutaneous coronary intervention, catheter ablation, biventricular pacing or cardiac resynchronization therapy (CRT) and CRT-defibrillator use, and implantable cardioverter defibrillator use;mechanical engineering, such as left ventricular assistant device use, internal artery balloon counteq^ulsation, cardiac support device use, and total artificial heart implantation;surgical engineering, such as coronary artery bypass graft, valve replacement or repair of rheumatic or congenital heart diseases, and heart transplantation (HT);regenerate engineering, which includes gene therapy, stem cell transplantation, and tissue engineering;and rehabilitating engineering, which includes exercise training, low-salt diet, nursing, psychological interventions, health education, and external counterpulsation/enhanced external counterpulsation in the outpatient department. These biomedical engineering therapies have greatly improved the symptoms of CHF and life expectancy. To date, pharmacotherapy, which is based on evidence-based medicine, large-scale, multi-center, randomized controlled clinical trials, is still a major treatment option for CHF;the current interventional and mechanical device engineering treatment for advanced CHF is not enough owing to its individual status. In place of HT or the use of a total artificial heart, stem cell technology and gene therapy in regenerate engineering for CHF are very promising. However, each therapy has its advantages and disadvantages, and it is currently possible to select better therapeutic strategies for patients with CHF according to cost-efficacy analyses of these therapies. Taken together, we think that a new era of biomedical engineering for CHF has begun.

Novel strategies halt cardiovascular, diabetes, and cancer strips

In this article, we introduce briefly several strategies for preventing atherosclerotic cardiovascular disease and promoting healthcare for non-communicable diseases (NCDs). These novel strategies include four core elements of health-sleep, emotion, exercise, and diet-and consist of SEED intervention (SEEDi) and E(e)SEEDi due to supplementation of the environment as a core element, and Hu's healthy lifestyles intervention (HHLi) which originates from E(e)SEED-BasED healthy lifestyles. They are suitable for the early evaluation of risk factors, and play a key role in the prevention and management of human NCDs when combined with the RT-ABCDEF strategy and the Grade 210 prevention, which include obesity-OSA-hypertension syndrome and C-type hypertension, especially in halting cardiovascular, diabetes and cancer (CDC) strips we first discovered. After successful clinical practice, we may expect our novel strategies for controlling these chronic diseases according to the conception of mass prevention and treatment.

New ＂P＂ in Medical Model

To the Editor： With the increase of human noncommunicable disease （NCD） and the release of Big Health Data in China in March 2015, people need to call for more effective action to address the challenges posed by NCD. For example, according to the latest evidence in the Global Burden of Disease Study 2013, for most cotlntries, NCD remains a leading cause of death. In general, people accept the preventive, predictive, personalized, and participation, or ＂4P＂ medical model from treatment to prevention as an effective strategy. For example, exceptional responders can help scientists predict the responses of many patients with cancer. Therefore, the authors propose adding another ＂P＂, that is, ＂Platform＂ to the medical model. Constructing new platform that may help people tackle the increase of NCD in China, and globally, is a further challenge.

Structure-editing： A New Branch？

To the Editor： As we all known, structure determines and influences biological function and mechanisms. Biological structure-editing （SE） means by using those magical and novel technologies （including single, multiple, or hybrid） with biological hazard and challenge to edit or reform known and disclosed biological structures of different levels so that people can translate SE into basic research or clinical application. As a new branch of structure biology, the authors think that its field focuses mainly on several facets.