Dear Editor,Glutamate excitotoxicity due to its accumulation in the extracellular space is a major factor to the brain damage that occurs during the early stages of cerebral ischemia1.GLT-1 is mainly expressed in astr...Dear Editor,Glutamate excitotoxicity due to its accumulation in the extracellular space is a major factor to the brain damage that occurs during the early stages of cerebral ischemia1.GLT-1 is mainly expressed in astrocytes,and it is responsible for almost 90%of glutamate uptake in the brain2.Although GLT-1 upregulation under the administration of ceftriaxone reduces ischemic brain damage,translational application of ceftriaxone in acute ischemia treatment is limited because several days are needed for the upregulation of GLT-1^(3),which misses the critical time window during which suppression of excitotoxicity will be effective.展开更多
基金the National Natural Science Foundation of China(81830034)Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Fundamental Research Institutions(2021SHIBS0002)Shenzhen Science and Technology Innovation Committee Research Grants(JCYJ20180504165806229,KQJSCX20180322151111754 to S.T.H.).
文摘Dear Editor,Glutamate excitotoxicity due to its accumulation in the extracellular space is a major factor to the brain damage that occurs during the early stages of cerebral ischemia1.GLT-1 is mainly expressed in astrocytes,and it is responsible for almost 90%of glutamate uptake in the brain2.Although GLT-1 upregulation under the administration of ceftriaxone reduces ischemic brain damage,translational application of ceftriaxone in acute ischemia treatment is limited because several days are needed for the upregulation of GLT-1^(3),which misses the critical time window during which suppression of excitotoxicity will be effective.
