Minimally invasive thalamic hematoma drainage can improve the six-month outcome of thalamic hemorrhage

为了探索 thalamic 出血的 6 月的临床的结果的预言者，并且如果最低限度地侵略的 thalamic hematoma 排水(THD ) 能与自发的 thalamic 改进它 54 个病人的 prognosis.MethodsA 总数，评估，出血回顾地被评估。包括人口分布，击风险因素， neuroimaging 变量，承认上的格拉斯哥昏迷分数(GCS ) ，外科的策略，和结果，临床的数据是镇定的。临床的结果用修改 Rankin 规模被估计，六 ? 在发作以后的月。 Univariate 分析和 multivariate 逻辑回归分析被执行决定差的 outcome.ResultsConservative 治疗的预言者为五个病人(9.3%)被执行，为 20 个病人(37.0%)的外部室的排水( EVD )，为四个病人(7.4%)的 THD ，并且 EVD 为 25 个病人(46.3%)与 THD 结合了。在在发作以后的六个月， 21 (38.9%) 病人们完成了有利结果，当(61.1%) 33 有差的结果时。在 univariate 分析，差的 6 月的结果的预言者是承认上的更低的 GCS (P = 0.001 ) ，更大的 hematoma 体积(P < 0.001 ) ，中线移动(P = 0.035 ) ，急性脑水肿(P = 0.039 ) ，并且没有 THD (P = 0.037 ) 。差的结果的独立预言者，根据 multivariate 逻辑回归分析，不是 volume.ConclusionsMinimally 侵略的 THD，在一些天以内移开大多数 hematoma，改进了的 THD 和更大的 hematoma thalamic 的 6 月的结果出血。因此， THD 能广泛地被使用与 thalamic 出血对待病人。

A feasible strategy for focal cerebral ischemiareperfusion injury: remote ischemic postconditioning

It is difficult to control the degree of ischemic postconditioning in the brain and other isch- emia-sensitive organs. Remote ischemic postconditioning could protect some ischemia-sensitive organs through measures on terminal organs. In this study, a focal cerebral ischemia-reperftlsion injury model was established using three cycles of remote ischernic postconditioning, each cycle consisted of 10-minute occlusion of the femoral artery and 10-minute opening. The results showed that, remote ischemic postconditioning significantly decreased the percentage of the in- farct area and attenuated brain edema. In addition, inflammatory nuclear factor-KB expression was significantly lower, while anti-apoptotic Bcl-2 expression was significantly elevated in the ce- rebral cortex on the ischemic side. Our findings indicate that remote ischemic postconditioning attenuates focal cerebral ischemia/reperfusion injury, and that the neuroprotective mechanism is mediated by an anti-apoptotic effect and reduction of the inflammatory response.