Dear Editor,As an illuminating cancer hallmark,polymorphic microbiomes profoundly impact cancer phenotypes by promoting or repressing cancer initiation and progression.1 Diversity and composition in the gut microbiome...Dear Editor,As an illuminating cancer hallmark,polymorphic microbiomes profoundly impact cancer phenotypes by promoting or repressing cancer initiation and progression.1 Diversity and composition in the gut microbiome are significantly associated with the response rate of anti-PD1 immunotherapy in melanoma.2 In addition to the gut microbiome,a large number of microbiomes colonizing in human tumors have been shown to play significant roles in cancer development.3 However,a comprehensive understanding of intratumor microbiomes in cancer immunotherapy is lacking,largely due to the challenge of investigating intratumor microbiomes in anti-cancer immunotherapy.展开更多
基金National Key Research and Development Program of China(2019YFE0120800,2019YFA0111600)Natural Science Foundation of China for outstanding Young Scholars(82022060)+7 种基金National Natural Science Foundation of China(81902149,81874242,31800979,82073145)Natural Science Foundation of Hunan Province for outstanding Young Scholars(2019JJ30040)Talent Young Scholars of Hunan Province(2019RS2009)Natural Science Foundation of Hunan Province(2020JJ5892)Shanghai Pujiang Program(21PJ1401700)Natural Science Foundation of Hunan Province for outstanding Young Scholars(2019JJ30040)Talent Young Scholars of Hunan Province(2019RS2009)We regret that page limitations have prevented us from including all the relevant studies in this letter.
文摘Dear Editor,As an illuminating cancer hallmark,polymorphic microbiomes profoundly impact cancer phenotypes by promoting or repressing cancer initiation and progression.1 Diversity and composition in the gut microbiome are significantly associated with the response rate of anti-PD1 immunotherapy in melanoma.2 In addition to the gut microbiome,a large number of microbiomes colonizing in human tumors have been shown to play significant roles in cancer development.3 However,a comprehensive understanding of intratumor microbiomes in cancer immunotherapy is lacking,largely due to the challenge of investigating intratumor microbiomes in anti-cancer immunotherapy.
