Q fever is an uncommon zoonotic rickettsial disease with no exanthem or speci fic cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69- year-old Spanish woman with chronic myelogen...Q fever is an uncommon zoonotic rickettsial disease with no exanthem or speci fic cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69- year-old Spanish woman with chronic myelogenous leukaemia deve loped fever and two subcutaneous nodules. The patient complained of extreme pain . Biopsy revealed a granulomatous lobular panniculitis with a characteristic ‘ fibrin ring’ or ‘ doughnut’ appearance: fibrin and inflammatory cells arran ged around a central clear space. Changes of membranous lipodystrophy were also found. Q fever serological studies were positive. Our patient had panniculitis w ith singular histopathological features. These histopathological changes have be en described in liver and bone marrow of patients with Q fever. To the best of o ur knowledge, this cutaneous involvement due to Q fever has not previously been described in the literature.展开更多
文摘Q fever is an uncommon zoonotic rickettsial disease with no exanthem or speci fic cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69- year-old Spanish woman with chronic myelogenous leukaemia deve loped fever and two subcutaneous nodules. The patient complained of extreme pain . Biopsy revealed a granulomatous lobular panniculitis with a characteristic ‘ fibrin ring’ or ‘ doughnut’ appearance: fibrin and inflammatory cells arran ged around a central clear space. Changes of membranous lipodystrophy were also found. Q fever serological studies were positive. Our patient had panniculitis w ith singular histopathological features. These histopathological changes have be en described in liver and bone marrow of patients with Q fever. To the best of o ur knowledge, this cutaneous involvement due to Q fever has not previously been described in the literature.
