MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation

A recent work of Iliopoulos et al published in Cell highlighted a circuit orchestrated by microRNAs (miRNAs) that results in liver tumorigenesis and inflammation. This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. These promising data support the use of miRNA mimics or inhibitors as potent therapeutic approaches in liver cancer.

把握双循环战略,加快我国力车胎产业由大到强的进程

力车胎行业主导产品为自行车胎、摩托车胎、电动自行(摩托)车胎、手推车胎和各种与低速车辆、小微型车辆配套使用的小轮径轮胎。现阶段全球力车胎产品市场不仅异常庞大,而且有着非常广阔的发展前景。经历百年的我国力车胎行业,已经发展成为世界最大的力车胎产品生产、消费和出口国。“十二五”、“十三五”期间,我国力车胎行业创新步伐不断加快,产品制造技术整体有了显著提升,局部跃居世界先进水平,既巩固和发展了我国通用型力车胎产品在世界力车胎产业中的比较优势,又初步打开了我国力车胎产业通往先进制造业的大门,具备了由力车胎大国迈向力车胎强国的坚实基础。

In-vitro proliferation assay with recycled ascitic cancer cells in malignant pleural mesothelioma: A case report

BACKGROUND We report the first case,to the best of our knowledge,of massive ascites due to recurrent malignant pleural mesothelioma that was controlled using KM-cell-free and concentrated ascites reinfusion therapy(KM-CART).The tumor cells derived via KM-CART were utilized secondarily in an in vitro cell growth assay using the collagen gel droplet-embedded culture drug sensitivity test(CD-DST)to investigate anticancer drug susceptibility.CASE SUMMARY A 56-year-old man presented with recurrent malignant mesothelioma with massive ascites;more than 4000 mL of ascitic fluid was removed,filtered,and concentrated using KM-CART,and the cell-free ascitic fluid was reinfused into the patient to improve quality of life.Cancer cells isolated secondarily in an in vitro proliferation assay using CD-DST exhibited low sensitivity to pemetrexed and high sensitivity to gemcitabine.Treatment with gemcitabine maintained stable disease for 4 mo.CONCLUSION The combination of KM-CART and CD-DST may be a promising treatment option for malignant ascites associated with malignant mesothelioma.

Noise Control of a Domestic Refrigerator Using a Natural Material Based Composite

This paper studies the acoustics of a frost free three door domestic refrigerator.Then,as a case study,the radiated noise reduction in the refrigerator using a natural material base composite is presented.Composites manufactured out of Jute,which is a plant fiber abundantly and cheaply available in India and Bangladesh are used in the noise reduction in the refrigerator.Mostly in this work,composites made out of felts of jute were used as barriers for noise control of the refrigerator.Measured acoustical,thermal and physical properties of various jute composites are reported.Noise sources in the refrigerator were characterized using sound intensity method and sound pressure level measurements.It is found that the compressor and the evaporator fan are the predominant noise sources.The jute composite treatment done to the refrigerator shell around the evaporator fan reduced the refrigerator noise level by 5 dB and improved its measured sound quality metrics without affecting the cooling performance of the refrigerator.

Postprandial triglyceride metabolism in elderly men with subnormal testosterone levels

Aim： To investigate the level of postprandial triglycerides （TG）s in elderly men with subnormal testosterone level （≤ 11.0 nmol/L） compared to men with normal testosterone level （〉 11.0 nmol/L）. Methods： Thirthy-seven men with subnormal and 41 men with normal testosterone aged 60-80 years underwent an oral fat load and TG levels were measured fasting and 2, 4, 6 and 8 h afterwards. Results： Men with subnormal testosterone had significantly higher body mass index （BMI） and waist circumference （P 〈 0.001） than men with normal testosterone. They had significantly higher area under curve （AUC, P = 0.037）, incremental area under curve （AUCi, P = 0.035） and TG response （TGR, P = 0.014） for serum-TG and significantly higher AUC （P = 0.023）, AUCi （P = 0.023） and TGR （P = 0.014） for chylomicron-TG compared to men with normal testosterone level. Adjusting for waist circumference erased the significant differences between the groups in postprandial triglyceridemia. Conclusion： Men with subnormal testosterone have increased postprandial TG levels indicating an impaired metabolism of postprandial TG-rich lipoproteins （TRL）, which may add to an unfavourable lipid profile and promote development of atherosclerosis.

Use of the Devil Fish in Animal Feed as an Alternative to Productive Diversification and Mitigation of Environmental Damage in the South and West of M^xico

The devil fish is a resource that can be used in animal feed. This fish is not used in Mexico for human consumption and has been regarded by fishermen as a pest; not having a use for this species has represented an ecological problem disposed on the banks of water bodies. This work allows to observe as a considered plague resource can be used in animal feed through its transformation in silage acid, thus contributing to the establishment of a new activity of the fishermen and providing the necessary protein for the production of pigs, sheep and cattle in the region, constituting both a complementary relationship： Fishermen obtain income by selling the silage to livestock producers and they get a good quality product that allows them to reduce the costs of food.

地球另一端的大耳朵

神秘而遥远的南美阿根廷,古老的印加文明对星空有着特殊的敬畏,河流是银河的倒影,星座的旋转预示着物候更替。如今,阿根廷的圣胡安省,国家天文台南美观测站正在建设之中,它吸引着全球各地的天文学家,相约星辰大海。

Measurement of the integrated Luminosities of cross-section scan data samples around theψ(3770)mass region

To investigate the nature of the Ψ（3770） resonance and to measure the cross section for e^＋e^-→DD, a cross-section scan data sample, distributed among 41 center-of-mass energy points from 3.73 to 3.89 GeV, was taken with the BESIII detector operated at the BEPCII collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of the data sample at each center-of-mass energy point. The total integrated luminosity of the data sample is 76.16±0.04±0.61 pb^-1, where the first uncertainty is statistical and the second systematic.

Evidence for the decays of ∧_c^+→∑^+η and ∑^+η’

We study the hadronic decays of ∧c+ to the final states ∑+η and ∑+η’,using an e+e-annihilation data sample of 567 pb-1 taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEPCⅡ collider.We find evidence for the decays ∧c+→∑+η and ∑+η’ with statistical significance of 2.5σ and 3.2σ,respectively.Normalizing to the reference decays ∧c+→∑+π0 and ∑+ω,we obtain the ratios of the branching fractions■and ■to be 0.35±0.16±0.02 and 0.86±0.34±0.04,respectively.The upper limits at the 90% confidence level are set to be■and■.Using BESIII measurements of the branching fractions of the reference decays,we determine B（∧c+→∑+η）=（0.41±0.19±0.05）%（<0.68%）and B（∧c+→∑+η’）=（1.34±0.53 ±0.19）%（<1.9%）.Here,the first uncertainties are statistical and the second systematic.The obtained branching fraction of ∧c+→∑+η is consistent with the previous measurement,and the branching fraction of ∧c+→∑+η’ is measured for the first time.

Observation of e^+e^-→D_s^+■^((*)0)K^- and study of the P-wave D_s mesons

Studies of e^+e~→D_s^+■^((*)0)K^-and the P-wave charmed-strange mesons are performed based on an e^+e^-collision data sample corresponding to an integrated luminosity of 567 pb^(-1) collected with the BESIII detector at s^(1/2)=4.600 GeV. The processes of e^+e^-→D_s^+■^(*0)K^- and D_s^+■~0K^- are observed for the first time and are found to be dominated by the modes D_s^+D_(s1)(2536)^-and D_s^+D_(s2)~*(2573)^-, respectively. The Born cross sections are measured to be σ~B(e^+e^-→D_s^+■^(*0)K^-) =(10.1±2.3±0.8) pb and σ~B(e^+e^-→D_s^+■~0K^-) =(19.4±2.3± 1.6) pb, and the products of Born cross section and the decay branching fraction are measured to be σ~B(e^+e^-→D_s^+D_(s1)(2536)^-+c.c.)·B(D_(s1)(2536)^-→■^(*0)K^-)=(7.5±1.8±0.7) pb and σ~B(e^+e^-→D_s^+D_(s2)~*(2573)^-+ c.c.)·B(D_(s2)~*(2573)^-→■~0 K^-)=(19.7 ± 2.9 ±2.0) pb. For the D_(s1)(2536)^-and D_(s2)~*(2573)^-mesons, the masses and widths are measured to be M(D_(s1)(2536)^-)=(2537.7±0.5 ±3.1) MeV/c2, Γ(D_(s1)(2536)^-) =(1.7 ±1.2 ±0.6)MeV, and M(D_(s2)~*(2573)^-)=(2570.7±2.0 ±1.7) MeV/c^2, Γ(D_(s2)~*(2573)^-)=(17.2 ±3.6 ±1.1) MeV. The spin-parity of the D_(s2)~*(2573)^-meson is determined to be J^p= 2^+. In addition, the processes e^+e^-→D_s^+■^((*)0)K^-are searched for using the data samples taken at four(two) center-of-mass energies between 4.416(4.527) and 4.575 GeV, and upper limits at the 90% confidence level on the cross sections are determined.