It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as‘‘protein corona',which directly interacts with and is recognized by cells.These ...It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as‘‘protein corona',which directly interacts with and is recognized by cells.These interactions play a critical role in affecting nanoparticle biological properties,including biodistribution[1],pathophysiology[2],and therapeutic efficacy[3].The compositions of protein corona undergo dynamic exchange in vivo and are展开更多
基金supported by the National Basic Research Program of China(2016YFA0201600)the Chinese Academy of Sciences Key Research Program for Frontier Sciences(QYZDJ-SSSLH022),the Chinese Academy of Sciences Interdisciplinary Innovation Teamthe National Science Fund for Distinguished Young Scholars(11425520)
文摘It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as‘‘protein corona',which directly interacts with and is recognized by cells.These interactions play a critical role in affecting nanoparticle biological properties,including biodistribution[1],pathophysiology[2],and therapeutic efficacy[3].The compositions of protein corona undergo dynamic exchange in vivo and are
