The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines.Taking substantial advantages of versatility and rapid devel...The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines.Taking substantial advantages of versatility and rapid development,two m RNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results.In this review,we outline keynotes in m RNA vaccine development,discuss recently published data on COVID-19 m RNA vaccine candidates,focusing on those in clinical trials and analyze future potential challenges.展开更多
基金supported by the National Key Research and Development Project(2020YFC0842300)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29040201)The National Natural Science Foundation of China(81901680)。
文摘The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines.Taking substantial advantages of versatility and rapid development,two m RNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results.In this review,we outline keynotes in m RNA vaccine development,discuss recently published data on COVID-19 m RNA vaccine candidates,focusing on those in clinical trials and analyze future potential challenges.
