Camptothecin is one of the most commonly used anticancer drugs worldwide,yet the downstream biosynthetic route from strictosidine to camptothecin has remained unclear for more than half a century.Here,we searched for ...Camptothecin is one of the most commonly used anticancer drugs worldwide,yet the downstream biosynthetic route from strictosidine to camptothecin has remained unclear for more than half a century.Here,we searched for proteins involved in camptothecin biosynthesis from the camptothecin-producing plant Ophiorrhiza pumila by chemoproteomics and identified Op CYP716E111.展开更多
基金supported financially by the National Key Research and Development Program of China(Grant No.2018YFA0900700)the National Natural Science Foundation of China(Nos.31901021+1 种基金31921006)the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences(Grant No.KFJ-BRP009)。
文摘Camptothecin is one of the most commonly used anticancer drugs worldwide,yet the downstream biosynthetic route from strictosidine to camptothecin has remained unclear for more than half a century.Here,we searched for proteins involved in camptothecin biosynthesis from the camptothecin-producing plant Ophiorrhiza pumila by chemoproteomics and identified Op CYP716E111.
