Perfect Reconstructable Decimated One-Dimensional Empirical Mode Decomposition Filter Banks

This paper introduces decimated filter banks for the one-dimensional empirical mode decomposition （1D-EMD）. These filter banks can provide perfect reconstruction and allow for an arbitrary tree structure. Since the EMD is a data driven decomposition, it is a very useful analysis instrument for non-stationary and non-linear signals. However, the traditional 1D-EMD has the disadvantage of expanding the data. Large data sets can be generated as the amount of data to be stored increases with every decomposition level. The 1D-EMD can be thought as having the structure of a single dyadic filter. However, a methodology to incorporate the decomposition into any arbitrary tree structure has not been reported yet in the literature. This paper shows how to extend the 1D-EMD into any arbitrary tree structure while maintaining the perfect reconstruction property. Furthermore, the technique allows for downsampling the decomposed signals. This paper, thus, presents a method to minimize the data-expansion drawback of the 1D-EMD by using decimation and merging the EMD coefficients. The proposed algorithm is applicable for any arbitrary tree structure including a full binary tree structure.

An Evolutionary Catch-up Strategy of Innovation： Knowledge Transfer of Chinese Hi-t：ech Multinationals Through Firm-University Cooperation

Chinese hi-tech multinationals strengthen their technological competitiveness in their internationalization process. Their strategic emphasis on cooperation with academic institutes to develop professional knowledge is an important yet underexplored issue in the extant literature. Based on the comparison between a pair of hi-tech companies--HUAWEI from China and CISCO from the US, this study analyzes the process of technological evolution of the former during 1998-2014, which ihas already become one of strategic solutions for Chinese multinationals （CMNE） to catch up with traditional counterparts in technological field. This study contributes to the present theory of CMNE by disclosing the Firm-University Cooperation （FUC） strategy, as well as its significance and implications for later-corner＇s catch-up trajectory in international business.

Fruit-Based Non-Dairy Beverage: A New Approach for Probiotics

The growing interest of consumers in using foods that improve health has motivated researchers and the food industry to develop new functional products such as foods with probiotics. Probiotic cultures, for example, from lactic acid bacteria and bifidobacteria have been highlighted for their ability to promote balance in the intestinal microbiota as well as other benefits such as anticarcinogenic and antimutagenic effects, reduced plasma cholesterol levels, decreased symptoms of lactose intolerance, and stimulation of the immune response. Traditionally, probiotics are incorporated into dairy products. However, because of the growing number of individuals affected by lactose intolerance and/or vegans, other food matrices have been studied as potential carriers for these microorganisms. Considering all the facts mentioned above, cereals, legumes, fruits, and vegetables could be potential substrates, where probiotic bacteria can be used for the development of non-dairy beverages. This review aimed to highlight the research carried out on 1) probiotic micro-organisms, including the more recent reclassification according to their phylogenetic position, 2) probiotic beverages from non-dairy sources which emerged as an alternative for lactose-intolerant consumers and, 3) the aspects of improving the gut microbiota.

From oral formulations to drug-eluting implants:using 3D and 4D printing to develop drug delivery systems and personalized medicine

Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

企业法务部“抢人”求解

当法务部着手找人接替行将退休的律师的时候，它们会发现，高质量的律师和合伙人律师（他们通常是备大公司赖以招揽内部律师的去处）人才储备之池正在桔竭。不仅如此，律师要在公司内部法务部门取得成功，需要特殊技能，但是律师事务所当下对他们在这方面的所花的培训时间更少了。为了补此不足，业内领头的法务部门，正在改变自己招聘的具体做法，以便更加迅速地发现人才，并通过增加对新千年一代人才的关切，以及为这些人打造引人注目的职业生涯发展通道，留住这些人才。

The Influence of Window Length Analysis on the Time and Frequency Domain of Mechanomyographic and Electromyographic Signals of Submaximal Fatiguing Contractions

Mechanomyography (MMG) acquires the oscillatory waves of contracting muscles. Electromyography (EMG) is a tool for monitoring muscle overall electrical activity. During muscle contractions, both techniques can investigate the changes that occur in the muscle properties. EMG and MMG parameters have been used for detecting muscle fatigue with diverse test protocols, sensors and filtering. Depending on the analysis window length (WLA), monitoring physiological events could be compromised due to imprecision in the determination of parameters. Therefore, this study investigated the influence of WLA variation on different MMG and EMG parameters during submaximal isometric contractions monitoring MMG and EMG parameters. Ten male volunteers performed isometric contractions of elbow joint. Triaxial accelerometer-based MMG sensor and EMG electrodes were positioned on the biceps brachii muscle belly. Torque was monitored with a load cell. Volunteers remained seated with hip and elbow joint at angles of 110° and 90°, respectively. The protocol consisted in maintaining torque at 70% of maximum voluntary contraction as long as they could. Parameter data of EMG and the modulus of MMG were determined for four segments of the signal. Statistical analysis consisted of analyses of variance and Fisher’s least square differences post-hoc test. Also, Pearson’s correlation was calculated to determine whether parameters that monitor similar physiological events would have strong correlation. The modulus of MMG mean power frequency (MPF) and the number of crossings in the baseline could detect changes between fresh and fatigued muscle with 1.0 s WLA. MPF and the skewness of the spectrum (μ3), parameters related to the compression of the spectrum, behaved differently when monitored with a triaxial MMG sensor. The EMG results show that for the 1.0 s and 2.0 s WLAs have normalized RMS difference with fatigued muscle and that there was strong correlation between parameters of different domains.

Influence of Saliva and Mucin on the Adhesion of <i>Candida</i>Oral Clinical Isolates

Objectives: This research work intends to clarify the role of artificial saliva, in particularly the role of mucin, a salivary protein, on the surface properties and adhesion ability of Candida spp. oral clinical isolates to abiotic surfaces. Methods: Four oral clinical isolates of Candida spp. were used: two Candida albicans strains (AC;AM) and two Candida parapsilosis strains (AD;AM2). The strains were isolated from patients using oral prosthesis. The microorganisms were cultured in the absence or presence of mucin and artificial saliva, and their adhesion to an abiotic surface (coated with mucin and artificial saliva) was evaluated. Results: The presence of mucin per se onto the abiotic surface decreased the adhesion of all strains, although the combination of mucin with artificial saliva had reduced this effect. No direct correlation between adhesion and the surface free energies of adhesion of the microorganisms was found. Significance: Candida spp. were human commensal microorganisms that became pathogenic when the host immune defenses were compromised. Medical devices were colonized by Candida spp. particularly, oral prostheses, which might lead to the degradation of the prostheses and systemic infections. The salivary secretions that constantly cover the oral cavity influenced Candida spp. adhesion process. Therefore, it was important to understand the interactions between Candida spp., salivary proteins and the characteristic of oral prosthesis when developing materials for oral prostheses.

伯恩哈德·温德沙伊德(1817-1892)——一位伟大的德国法学家的生平与作品

伯恩哈德·温德沙伊德被视为19世纪伟大的德国私法学家,该名誉特别但不仅仅是因为他著名的《学说汇纂教科书》和他对《德国民法典》的重要影响。下文将介绍温德沙伊德其人及其作品。此处将不仅介绍温德沙伊德的个人经历(一),还将根据德国当时的法律状况的描述(二),探讨其基本见解(三)、主要学术活动(四)。

Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies.In this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established trend.Particularly,in situ forming hydrogels have arisen as a new IBS generation.An in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive agents.In this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and 12weeks.The results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation process.Human multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS.These bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.