AIM: To study the mechanism involved in the potentially beneficial effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension, rats were pretreated with selective COX 1 or 2 inhibitors (SC-560 or NS-398...AIM: To study the mechanism involved in the potentially beneficial effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension, rats were pretreated with selective COX 1 or 2 inhibitors (SC-560 or NS-398 respectively), and subsequently injected with ULDA or placebo. METHODS: Portal hypertension was induced by portal vein ligation. Platelet activity was investigated with an in-vivo model of laser induced thrombus production in mesenteric circulation and induced hemorrhagic time (IHT). Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1α, TXB2, PGE2 and LTB4 were also performed. RESULTS: The portal hypertensive group receiving a placebo showed a decreased in vivo platelet activity with prolonged IHT, an effect that was normalized by ULDA. SC-560 induced a mild antithrombotic effect in the normal rats, and an unmodified effect of ULDA. NS-398 had a mild prothrombotic action in portal hypertensive rats, similar to ULDA, but inhibited a further effect when ULDA was added. An increased 6-keto-PGF1α was observed in portal hypertensive group that was normalised after ULDA administration. TXA2 level after ULDA, remained unchanged. CONCLUSION: These results suggest that the effect of ULDA on platelet activity in portal hypertensive rats, could act through a COX 2 pathway more than the COX 1, predominant for aspirin at higher doses.展开更多
The fossil record of birds from Antarctica is concentrated in the James Ross Basin,located in north-east of the Antarctic Peninsula.Birds are here represented by an extensive Paleogene record of penguins(Sphenisciform...The fossil record of birds from Antarctica is concentrated in the James Ross Basin,located in north-east of the Antarctic Peninsula.Birds are here represented by an extensive Paleogene record of penguins(Sphenisciformes)and Cretaceous–Paleogene record of Anseriformes,followed by other groups with a minor representation(Procellariiformes,Falconiformes,and Pelagornithidae),and others previously assigned controversially to“Ratites”,Threskiornithidae,Charadriiformes,Gruiformes,Phoenicopteriformes,and Gaviiformes.We provide a complete update of these records,commenting on the importance of some of these remains for the evolution of the major clades.展开更多
文摘AIM: To study the mechanism involved in the potentially beneficial effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension, rats were pretreated with selective COX 1 or 2 inhibitors (SC-560 or NS-398 respectively), and subsequently injected with ULDA or placebo. METHODS: Portal hypertension was induced by portal vein ligation. Platelet activity was investigated with an in-vivo model of laser induced thrombus production in mesenteric circulation and induced hemorrhagic time (IHT). Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1α, TXB2, PGE2 and LTB4 were also performed. RESULTS: The portal hypertensive group receiving a placebo showed a decreased in vivo platelet activity with prolonged IHT, an effect that was normalized by ULDA. SC-560 induced a mild antithrombotic effect in the normal rats, and an unmodified effect of ULDA. NS-398 had a mild prothrombotic action in portal hypertensive rats, similar to ULDA, but inhibited a further effect when ULDA was added. An increased 6-keto-PGF1α was observed in portal hypertensive group that was normalised after ULDA administration. TXA2 level after ULDA, remained unchanged. CONCLUSION: These results suggest that the effect of ULDA on platelet activity in portal hypertensive rats, could act through a COX 2 pathway more than the COX 1, predominant for aspirin at higher doses.
基金CAH was invited to field by the Dirección Nacional del Antártico and the Instituto Antártico ArgentinoFuerza Aérea Argentina provided logistic support,and partial help was provided by the Consejo Nacional de Investigaciones Científicas y Tecnológicas and Universidad Nacional de La Plata(N838)+1 种基金CAH is particularly grateful to Oceanwide Expeditions,Vlissingen(NL)for financial support.JAC gratefully acknowledges U.S National Science Foundation Polar Programs support for field research support as well as descriptive work on Antarctic fossils(Grant nos.NSF OPP-1141820,OPP-0927341,OPP-0408308)the work of many stellar collaborators on these projects.
文摘The fossil record of birds from Antarctica is concentrated in the James Ross Basin,located in north-east of the Antarctic Peninsula.Birds are here represented by an extensive Paleogene record of penguins(Sphenisciformes)and Cretaceous–Paleogene record of Anseriformes,followed by other groups with a minor representation(Procellariiformes,Falconiformes,and Pelagornithidae),and others previously assigned controversially to“Ratites”,Threskiornithidae,Charadriiformes,Gruiformes,Phoenicopteriformes,and Gaviiformes.We provide a complete update of these records,commenting on the importance of some of these remains for the evolution of the major clades.
