Dear Editor,We present a case of a healthy 32-year-old man who developed bilateral corneal ulceration 3 wk after commencing dupilumab for atopic dermatitis. Dupilumab is a recently introduced systemic monoclonal antib...Dear Editor,We present a case of a healthy 32-year-old man who developed bilateral corneal ulceration 3 wk after commencing dupilumab for atopic dermatitis. Dupilumab is a recently introduced systemic monoclonal antibody used in the treatment of moderate-to-severe atopic dermatitis, showing efficacy in clinical trials;. Several publications have reported ocular surface complications associated with dupilumab.展开更多
Purpose To examine the clinical features of undiagnosed openangle glaucoma (OA G) in people who have attended an eye care provider within the previous 12 month s and to suggest strategies to assist in the early detect...Purpose To examine the clinical features of undiagnosed openangle glaucoma (OA G) in people who have attended an eye care provider within the previous 12 month s and to suggest strategies to assist in the early detection of glaucoma. Design Population based cross-sectional study. Participants Permanent residents aged 40 years and older at recruitment during 1992 through 1996. Methods A cluster-s tratified random sample of 4744 participants from the urban and rural cohorts wa s studied. Structured standardized interviews and dilated ocular examinations we re conducted in all eligible participants. Data on demographic characteristics, prior knowledge of eye disease, use of eye care services, intraocular pressures, cup-to-disc ratios, visual fields, and photographyof optic discs were obtaine d. All suspected glaucoma cases were submitted to a panel of 6 ophthalmologists to determine glaucoma diagnosis. Main outcome measures Clinical features of part icipants seen by eye health professionals within the previous 12 months who have previously undiagnosed OAG, previously diagnosed OAG, and no glaucoma. Results Thirty-five previously undiagnosed and 43 previously diagnosed participants had visited an optometrist or ophthalmologist or both in the previous 12 months. Ag e and gender were not significantly different between the undiagnosed and diagno sed glaucoma cases. After logistic regression, the type of eye professional seen (odds ratio OR, 45.17; 95%confidence interval 95%CI, 5.89-346.17; P=0.00 02) and the presence of visual field defects (OR, 0.06; 95%CI, 0.01-0.69, P=0. 020)were the only statistically sig nificant variables between the diagnosed and undiagnosed glaucoma groups. Conc lusions Raised intraocular pressure should not be relied on as the only triggeri ng factor in glaucoma investigations.展开更多
The realization of high‐efficiency,reversible,stable,and safe Li‐O2 batteries is severely hindered by the large overpotential and side reactions,especially at high rate conditions.Therefore,rational design of cathod...The realization of high‐efficiency,reversible,stable,and safe Li‐O2 batteries is severely hindered by the large overpotential and side reactions,especially at high rate conditions.Therefore,rational design of cathode catalysts with high activity and stability is crucial to overcome the terrible issues at high current density.Herein,we report a surface engineering strategy to adjust the surface electron structure of boron(B)‐doped PtNi nanoalloy on carbon nanotubes(PtNiB@CNTs)as an efficient bifunctional cathodic catalyst for high‐rate and long‐life Li‐O2 batteries.Notably,the Li‐O2 batteries assembled with as‐prepared PtNiB@CNT catalyst exhibit ultrahigh discharge capacity of 20510 mA·h/g and extremely low overpotential of 0.48 V at a high current density of 1000 mA/g,both of which outperform the most reported Pt‐based catalysts recently.Meanwhile,our Li‐O2 batteries offer excellent rate capability and ultra‐long cycling life of up to 210 cycles at 1000 mA/g under a fixed capacity of 1000 mA·h/g,which is two times longer than those of Pt@CNTs and PtNi@CNTs.Furthermore,it is revealed that surface engineering of PtNi nanoalloy via B doping can efficiently tailor the electron structure of nanoalloy and optimize the adsorption of oxygen species,consequently delivering excellent Li‐O2 battery performance.Therefore,this strategy of regulating the nanoalloy by doping nonmetallic elements will pave an avenue for the design of high‐performance catalysts for metal‐oxygen batteries.展开更多
文摘Dear Editor,We present a case of a healthy 32-year-old man who developed bilateral corneal ulceration 3 wk after commencing dupilumab for atopic dermatitis. Dupilumab is a recently introduced systemic monoclonal antibody used in the treatment of moderate-to-severe atopic dermatitis, showing efficacy in clinical trials;. Several publications have reported ocular surface complications associated with dupilumab.
文摘Purpose To examine the clinical features of undiagnosed openangle glaucoma (OA G) in people who have attended an eye care provider within the previous 12 month s and to suggest strategies to assist in the early detection of glaucoma. Design Population based cross-sectional study. Participants Permanent residents aged 40 years and older at recruitment during 1992 through 1996. Methods A cluster-s tratified random sample of 4744 participants from the urban and rural cohorts wa s studied. Structured standardized interviews and dilated ocular examinations we re conducted in all eligible participants. Data on demographic characteristics, prior knowledge of eye disease, use of eye care services, intraocular pressures, cup-to-disc ratios, visual fields, and photographyof optic discs were obtaine d. All suspected glaucoma cases were submitted to a panel of 6 ophthalmologists to determine glaucoma diagnosis. Main outcome measures Clinical features of part icipants seen by eye health professionals within the previous 12 months who have previously undiagnosed OAG, previously diagnosed OAG, and no glaucoma. Results Thirty-five previously undiagnosed and 43 previously diagnosed participants had visited an optometrist or ophthalmologist or both in the previous 12 months. Ag e and gender were not significantly different between the undiagnosed and diagno sed glaucoma cases. After logistic regression, the type of eye professional seen (odds ratio OR, 45.17; 95%confidence interval 95%CI, 5.89-346.17; P=0.00 02) and the presence of visual field defects (OR, 0.06; 95%CI, 0.01-0.69, P=0. 020)were the only statistically sig nificant variables between the diagnosed and undiagnosed glaucoma groups. Conc lusions Raised intraocular pressure should not be relied on as the only triggeri ng factor in glaucoma investigations.
基金supported by the National Natural Science Foundation of China(Nos.22125903 and 51872283)Dalian Innovation Support Plan for High Level Talents(No.2019RT09)+2 种基金Dalian National Laboratory for Clean Energy(DNL),CAS,DNL Cooperation Fund,CAS(Nos.DNL201912,DNL201915,DNL202016,and DNL202019)DICP(No.DICP I2020032)the Joint Fund of the Yulin University and the Dalian National Laboratory for Clean Energy(Nos.YLU‐DNL Fund 2021002 and YLU‐DNL 2021009).
文摘The realization of high‐efficiency,reversible,stable,and safe Li‐O2 batteries is severely hindered by the large overpotential and side reactions,especially at high rate conditions.Therefore,rational design of cathode catalysts with high activity and stability is crucial to overcome the terrible issues at high current density.Herein,we report a surface engineering strategy to adjust the surface electron structure of boron(B)‐doped PtNi nanoalloy on carbon nanotubes(PtNiB@CNTs)as an efficient bifunctional cathodic catalyst for high‐rate and long‐life Li‐O2 batteries.Notably,the Li‐O2 batteries assembled with as‐prepared PtNiB@CNT catalyst exhibit ultrahigh discharge capacity of 20510 mA·h/g and extremely low overpotential of 0.48 V at a high current density of 1000 mA/g,both of which outperform the most reported Pt‐based catalysts recently.Meanwhile,our Li‐O2 batteries offer excellent rate capability and ultra‐long cycling life of up to 210 cycles at 1000 mA/g under a fixed capacity of 1000 mA·h/g,which is two times longer than those of Pt@CNTs and PtNi@CNTs.Furthermore,it is revealed that surface engineering of PtNi nanoalloy via B doping can efficiently tailor the electron structure of nanoalloy and optimize the adsorption of oxygen species,consequently delivering excellent Li‐O2 battery performance.Therefore,this strategy of regulating the nanoalloy by doping nonmetallic elements will pave an avenue for the design of high‐performance catalysts for metal‐oxygen batteries.
