Background:Liver transplantation(LT)for neuroendocrine liver metastases(NELM)is still in debate.Studies comparing LT with liver resection(LR)for NELM are scarce,as patient selection is heterogeneous and experience is ...Background:Liver transplantation(LT)for neuroendocrine liver metastases(NELM)is still in debate.Studies comparing LT with liver resection(LR)for NELM are scarce,as patient selection is heterogeneous and experience is limited.The goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatment of NELM.Data sources:A scoping literature search on LT and LR for NELM was performed with PubMed,including English articles up to March 2023.Results:International guidelines recommend LR for NELM in resectable,well-differentiated tumors in the absence of extrahepatic metastatic disease with superior results of LR compared to systemic or liver-directed therapies.Advanced liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free survival.In highly selected patients(based on the Milan criteria)with unresectable NELM,oncologic results of LT are promising.Prognostic factors include tumor biology(G1/G2)and burden,waiting time for LT,patient age and extrahepatic spread.Based on low-level evi-dence,LT for low-grade NELM within the Milan criteria resulted in improved disease-free survival and overall survival compared to LR.The benefits of LT were lost in patients beyond the Milan NELM-criteria.Conclusions:With adherence to strict selection criteria especially tumor biology,LT for NELM is becoming a valuable option providing oncologic benefits compared to LR.Recent evidence suggests even stricter selection criteria with regard to tumor biology.展开更多
The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese...The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in 2025.SXI is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE orbit.SXI is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s exosphere.SWCX provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field lines.The sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many hours.SXI is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.展开更多
About 2 percent of red clump stars are found to be the lithium-rich and thus the surface lithium increases obviously in some red clump stars.The physical mechanism of the lithium enrichment in these stars has not yet ...About 2 percent of red clump stars are found to be the lithium-rich and thus the surface lithium increases obviously in some red clump stars.The physical mechanism of the lithium enrichment in these stars has not yet been explained satisfactorily by the evolutionary models of single stars.The flash induced internal gravity wave mixing(i.e.,IGW)could play a primary role in explaining the red clump star with lithium enrichment and it has a very significant impact on the internal structure and surface compositions of a star.Rotation can significantly increase the mixing efficiency of the internal gravity wave because the timescale for the enrichment event has been enlarged.Thermohaline mixing can explain the observed behavior of lithium on red giant stars that are more luminosity than the RGB bump.However,it has a very small effect on the diffusion of elements because its diffusion coefficient is much smaller than the one of IGW induced mixing after the core helium flash.展开更多
By using muon spin relaxation(μSR)measurements,we perform a comparative study of the microscopic magnetism in the parent compounds of infinite-layer nickelate superconductors RNiO_(2)(R=La,Nd).In either compound,the ...By using muon spin relaxation(μSR)measurements,we perform a comparative study of the microscopic magnetism in the parent compounds of infinite-layer nickelate superconductors RNiO_(2)(R=La,Nd).In either compound,the zero-fieldμSR spectra down to the lowest measured temperature reveal no long-range magnetic order.In LaNiO_(2),short-range spin correlations appear below T=150 K,and spins fully freeze below T∼10 K.NdNiO_(2)exhibits a more complex spin dynamics driven by the Nd 4f and Ni3d electron spin fluctuations.Further,it shows features suggesting the proximity to a spin-glass state occurring below T=5 K.In both compounds,the spin behavior with temperature is further confirmed by longitudinal-field μSR measurements.These results provide new insight into the magnetism of the parent compounds of the superconducting nickelates,crucial to understanding the microscopic origin of their superconductivity.展开更多
1.Aging and exercise Aging is associated with the decline of cellular,tissue,and systemic functions and is characterized by at least 7 highly interdependent molecular pillars of aging1(Fig.1).Besides compromised genet...1.Aging and exercise Aging is associated with the decline of cellular,tissue,and systemic functions and is characterized by at least 7 highly interdependent molecular pillars of aging1(Fig.1).Besides compromised genetic functions(telomer shortening and epigenetic dysregulation),metabolic efficiency(impaired mitochondrial functions and nutrient sensing),and cellular stress responses deteriorate.Consequential disruption of normal protein regulation(proteostasis)in combination with impaired cellular waste clearance leads to the accumulation of macromolecular damage(and in some cases to specific protein aggregation pathologies,like in Alzheimer’s dementia brains).展开更多
1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters...1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters.1 The cost of hosting a major international tournament is eye-wateringly high.Host governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent.展开更多
文摘Background:Liver transplantation(LT)for neuroendocrine liver metastases(NELM)is still in debate.Studies comparing LT with liver resection(LR)for NELM are scarce,as patient selection is heterogeneous and experience is limited.The goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatment of NELM.Data sources:A scoping literature search on LT and LR for NELM was performed with PubMed,including English articles up to March 2023.Results:International guidelines recommend LR for NELM in resectable,well-differentiated tumors in the absence of extrahepatic metastatic disease with superior results of LR compared to systemic or liver-directed therapies.Advanced liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free survival.In highly selected patients(based on the Milan criteria)with unresectable NELM,oncologic results of LT are promising.Prognostic factors include tumor biology(G1/G2)and burden,waiting time for LT,patient age and extrahepatic spread.Based on low-level evi-dence,LT for low-grade NELM within the Milan criteria resulted in improved disease-free survival and overall survival compared to LR.The benefits of LT were lost in patients beyond the Milan NELM-criteria.Conclusions:With adherence to strict selection criteria especially tumor biology,LT for NELM is becoming a valuable option providing oncologic benefits compared to LR.Recent evidence suggests even stricter selection criteria with regard to tumor biology.
基金funding and support from the United Kingdom Space Agency(UKSA)the European Space Agency(ESA)+5 种基金funded and supported through the ESA PRODEX schemefunded through PRODEX PEA 4000123238the Research Council of Norway grant 223252funded by Spanish MCIN/AEI/10.13039/501100011033 grant PID2019-107061GB-C61funding and support from the Chinese Academy of Sciences(CAS)funding and support from the National Aeronautics and Space Administration(NASA)。
文摘The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in 2025.SXI is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE orbit.SXI is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s exosphere.SWCX provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field lines.The sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many hours.SXI is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.
基金supported by the National Natural Science Foundation of China(Grant Nos.11863003 and 12173010)the Science and Technology Plan Projects of Guizhou Province(Grant No.[2018]5781).
文摘About 2 percent of red clump stars are found to be the lithium-rich and thus the surface lithium increases obviously in some red clump stars.The physical mechanism of the lithium enrichment in these stars has not yet been explained satisfactorily by the evolutionary models of single stars.The flash induced internal gravity wave mixing(i.e.,IGW)could play a primary role in explaining the red clump star with lithium enrichment and it has a very significant impact on the internal structure and surface compositions of a star.Rotation can significantly increase the mixing efficiency of the internal gravity wave because the timescale for the enrichment event has been enlarged.Thermohaline mixing can explain the observed behavior of lithium on red giant stars that are more luminosity than the RGB bump.However,it has a very small effect on the diffusion of elements because its diffusion coefficient is much smaller than the one of IGW induced mixing after the core helium flash.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFA1402203)the National Natural Science Foundation of China(Grant No.12174065)supported by the Shenzhen Fundamental Research Program(Grant Nos.JCYJ20220818100405013 and JCYJ20230807093204010)。
文摘By using muon spin relaxation(μSR)measurements,we perform a comparative study of the microscopic magnetism in the parent compounds of infinite-layer nickelate superconductors RNiO_(2)(R=La,Nd).In either compound,the zero-fieldμSR spectra down to the lowest measured temperature reveal no long-range magnetic order.In LaNiO_(2),short-range spin correlations appear below T=150 K,and spins fully freeze below T∼10 K.NdNiO_(2)exhibits a more complex spin dynamics driven by the Nd 4f and Ni3d electron spin fluctuations.Further,it shows features suggesting the proximity to a spin-glass state occurring below T=5 K.In both compounds,the spin behavior with temperature is further confirmed by longitudinal-field μSR measurements.These results provide new insight into the magnetism of the parent compounds of the superconducting nickelates,crucial to understanding the microscopic origin of their superconductivity.
文摘1.Aging and exercise Aging is associated with the decline of cellular,tissue,and systemic functions and is characterized by at least 7 highly interdependent molecular pillars of aging1(Fig.1).Besides compromised genetic functions(telomer shortening and epigenetic dysregulation),metabolic efficiency(impaired mitochondrial functions and nutrient sensing),and cellular stress responses deteriorate.Consequential disruption of normal protein regulation(proteostasis)in combination with impaired cellular waste clearance leads to the accumulation of macromolecular damage(and in some cases to specific protein aggregation pathologies,like in Alzheimer’s dementia brains).
文摘1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters.1 The cost of hosting a major international tournament is eye-wateringly high.Host governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent.
