Osteoclasts are multinucleated bone-resorbing cells,and their formation is tightly regulated to prevent excessive bone loss.However,the mechanisms by which osteoclast formation is restricted remain incompletely determ...Osteoclasts are multinucleated bone-resorbing cells,and their formation is tightly regulated to prevent excessive bone loss.However,the mechanisms by which osteoclast formation is restricted remain incompletely determined.Here,we found that sterol regulatory element binding protein 2(SREBP2)functions as a negative regulator of osteoclast formation and inflammatory bone loss.Cholesterols and SREBP2,a key transcription factor for cholesterol biosynthesis,increased in the late phase of osteoclastogenesis.展开更多
基金supported by the National Institute of Arthritis and Musculoskeletal and Skin diseases (NIAMS)of NIH under Award Number R01 AR069562 and AR073156 (to K.H.P.-M.)by the National Research Foundation of Korea NRF2020R1A6A3A03037133 (to H.K.)+1 种基金by the support for the Rosensweig Genomics Center from The Tow Foundation,and by R03 AR068118 (to L.D.)NIH/NCI Cancer Center Support Grant P30 CA008748 (to L.D.)。
文摘Osteoclasts are multinucleated bone-resorbing cells,and their formation is tightly regulated to prevent excessive bone loss.However,the mechanisms by which osteoclast formation is restricted remain incompletely determined.Here,we found that sterol regulatory element binding protein 2(SREBP2)functions as a negative regulator of osteoclast formation and inflammatory bone loss.Cholesterols and SREBP2,a key transcription factor for cholesterol biosynthesis,increased in the late phase of osteoclastogenesis.
