儿童家长的正念特质与养育胜任感之间的关系

目的:探讨儿童家长的正念特质和养育胜任感之间的关系,并探索家长自身的正念教养及一般健康水平在其关系中的中介作用。方法:选取山西省和香港特别行政区4所小学的儿童家长共395人。使用正念注意知觉量表(MAAS)、养育胜任感量表(PSOC)、正念教养量表(IM-P)及一般健康问卷(GHQ)进行测量,调查数据来自家长的自我报告。结果:家长的MAAS得分与PSOC、IM-P、GHQ得分均呈正相关(r=0. 47～0. 57,均P <0. 01),家长的PSOC得分与IM-P、GHQ得分均呈正相关(r=0. 52～0. 58,均P <0. 01)。家长正念教养对正念特质和养育胜任感之间的关系具有中介作用,Bootstrap输出的95%可信区间为0. 10～0. 22;家长的一般健康水平对正念特质和养育胜任感之间的关系具有中介作用,Bootstrap输出的95%可信区间为0. 05～0. 16。总的中介作用占总效应的71. 55%。结论:正念特质水平高的家长更容易具备高水平的养育胜任感,家长的正念教养和自身一般健康水平对这一关系具有中介作用。

儿童单倍型造血干细胞移植后HHV-6病毒性脑炎二例报告并文献复习

人类疱疹病毒6型(HHV-6)属于人疱疹病毒β-疱疹病毒科,大多数3岁以内的儿童会感染HHV-6,且在初次感染后进入潜伏期。HHV-6可在免疫受损的宿主中再活化。一般来说,造血干细胞移植(HSCT)后HHV-6再激活的发生率为30%~70%[1],脐血干细胞移植(CBT)后的发生率会更高。大部分患者移植后HHV-6再激活表现为HHV-6血症,仅少数患者发生HHV-6相关脑炎。CBT患者HHV-6脑炎的发生率为4.9%~21.4%,在非CBT患者中发生率为0~11.6%[2]。目前国内单倍型HSCT(haplo-HSCT)蓬勃发展,但haplo-HSCT后HHV-6脑炎具体发生率缺乏相关数据。我们报告2例haplo-HSCT后HHV-6脑炎诊治经过,对移植后HHV-6脑炎进行文献复习。

A pilot study on the relationship between thyroid status and neuropsychiatric symptoms in patients with Alzheimer disease

Background Growing evidence links alternation of the thyroid function to the pathogenesis and progression of Alzheimer disease （AD）. However, only a few studies evaluate the association between thyroid hormone levels and neuropsychiatric manifestations in patients with AD. This study aimed to investigate the relationship of thyroid hormone levels and neuropsychiatric symptoms in euthyroid patients with AD. Methods Forty patients with AD （26 women and 14 men）, with no prior AD treatment within 4 weeks before study entry, were evaluated on their thyroid status （total triiodothyronine （TT3）,total thyroxine （TT4）, and thyroid-stimulating hormone （TSH）, cognition （Mini-Mental State Examination （MMSE） and Alzheimer＇s disease Assessment Scale-Cognitive Subscale （ADAS-cog）, neuropsychiatric symptoms （Neuropsychiatric Inventory （NPI） and depression （Hamilton Rating Scale for Depression （HAMD17）. The unique relationship between thyroid hormones and cognitive function and mood was examined with multivariate linear regression analyses. The thyroid status between the neuropsychiatric symptoms group and the non-neuropsychiatric symptoms group was examined with independent-samples t-test. Results In euthyroid AD patients with agitation and irritability has lower TSH serum level than those without these symptoms （t=-2.130, P 〈0.05; t=-2.657, P 〈0.05）; and core score of HAMD is significantly associated with the serum level of TSH （β=0.395, P 〈0.01）. There is no significant association between thyroid hormone levels and cognition （MMSE, ADAS-cog and its subscale score）.