The AMS measurement of ^236U at CIRCE

Accelerator mass spectrometry(AMS) is an ultrasensitive technique for measuring long-lived actinides,e.g.,^(236)U,^(237)Np and Pu isotopes.In order to improve the detection limit for actinides abundance,and to increase the detection efficiency in actinides AMS measurement,a 16-strip silicon detector was used to identify actinides at the Center for Isotopic Research on Cultural and Environmental heritage in Caserta,Italy.The sensitivity of ^(236)U/^(238)U was 1×10^(-11) by special resolution and 5.0×10^(-12) by time resolution.The pulse height defect of^(236)U in an ion-implanted silicon detector in the low-energy range with 17.26 MeV is presented.

Using cemented paste backfill to tackle the phosphogypsum stockpile in China:A down-to-earth technology with new vitalities in pollutant retention and CO_(2) abatement

Phosphogypsum(PG),a hard-to-dissipate by-product of the phosphorus fertilizer production industry,places strain on the biogeochemical cycles and ecosystem functions of storage sites.This pervasive problem is already widespread worldwide and requires careful stewardship.In this study,we review the presence of potentially toxic elements(PTEs)in PG and describe their associations with soil properties,anthropogenic activities,and surrounding organisms.Then,we review different ex-/in-situ solutions for promoting the sustainable management of PG,with an emphasis on in-situ cemented paste backfill,which offers a cost-effective and highly scalable opportunity to advance the value-added recovery of PG.However,concerns related to the PTEs'retention capacity and long-term effectiveness limit the implementation of this strategy.Furthermore,given that the large-scale demand for ordinary Portland cement from this conventional option has resulted in significant CO_(2) emissions,the technology has recently undergone additional scrutiny to meet the climate mitigation ambition of the Paris Agreement and China's Carbon Neutrality Economy.Therefore,we discuss the ways by which we can integrate innovative strategies,including supplementary cementitious materials,alternative binder solutions,CO_(2) mineralization,CO_(2) curing,and optimization of the supply chain for the profitability and sustainability of PG remediation.However,to maximize the co-benefits in environmental,social,and economic,future research must bridge the gap between the feasibility of expanding these advanced pathways and the multidisciplinary needs.

Do False Beliefs Predict Increased Circumcision Satisfaction in Men?

Medical male circumcision has been adopted by the WHO, and other professional public health and medical bodies, as a vital weapon in the fight against HIV. This has prompted a large body of research into the acceptability of the procedure, attitudes to it, and barriers to it. A systematic review of these studies found that satisfaction with circumcision is strongly associated with having accurate knowledge about it. A survey-based paper by Earp, Sardi and Jellison entitled “False beliefs predict increased circumcision satisfaction in a sample of US American men” is the only one to find the opposite. It therefore merits scrutiny. The present article presents the results of a critical examination of the study. Serious flaws were discovered. Half of the small number of 10 “true/false” statements used in its survey are questionable. All the large body of literature that contradicts the findings of Earp and co-workers is ignored. Importantly, the crucial question about whether dissatisfied circumcised males hold false beliefs about circumcision is not considered. Unlike most of the research on the acceptability of circumcision, the study is not motivated by a desire to evaluate the likely effectiveness of a public health measure, or how best to implement it. Rather it appears to be an attempt by a prominent anti-circumcision activist and his associates to generate a body of literature that they can then cite to further their cause. Considering this, and the serious flaws it contains, the study should be dismissed as misleading, biased and undermining public health.

Complete resection of the hepatic veins: The role of right inferior vein

To the editor:In the recent years liver surgery has been dramatically improved because of technical and technological innovations,perioperative and intraoperative intensive care,better knowledge of liver physiology and early recognition and treatment of postoperative complications.Last but not least,liver anatomy,though not

Reference Islands Definition within INSULAE Project through KPIs

Most of the isolated electrical systems throughout the world suffer from similar problems of fragility and high dependence on external resources to generate energy. Smart Grid solutions and integration of renewable energies in order to solve their problems have increased, although it is necessary to know their specific characteristics to select the optimal solutions for each case. Therefore, as the overall objective of INSULAE Project, the development of an Investment Planning Tool, IPT, is on the way. This paper provides a view on a characterization methodology developed for the set of Reference Islands and how it will help to exploit the IPT developed. For that, characterization vectors have been defined based on a selection of Key Performance Indicators (KPIs). And Reference Islands have been obtained from the analysis of KPIs data gathered from EU islands considering the vectors formed. The linkage of new islands to reference islands helps provide the new islands with an assessment on the possibility space of their investment plans with the aim of being a decarbonization plan considering the demonstrations already evaluated.

Smart Grid Functionalities Evaluation

In the last years, with the advent of Smart Grids, many research and demonstration projects have seen the light in order to involve electric system in the implementation of advances in information and communication technologies, in order to improve network efficiency, reliability, security and quality of service. Before new implementations are performed, previous results have to be studied, and taken into account. In this line, this work presents the methodology, results and conclusions of the evaluation of the Smart Grid functionalities developed by 5 different DSOs during DISCERN project in order to select the optimal, cost-effective and most replicable solutions for the strategic development of the intelligence at medium voltage (MV) and low voltage (LV) networks.

皮层发育畸形患者皮层重构的脑磁图研究

Background: The evaluation for epilepsy surgery of patients with malformations of cortical development (MCDs) in areas of clinically important cerebral function is a challenge because of the unpredictable localization of critical sensory, motor, and cognitive function. Magnetoencephalography (MEG) source localization of evoked fields can address whether functional reorganization of primary sensory modalities exists in MCDs. Methods: Consecutive patients with MRI- demonstrated rolandic and calcarine cortex MCDs were identified who had a 148- channel whole- head MEG study to identify the localization of primary somatosensory and visual cortices. Reorganization was considered when localization contrasted that expected upon general anatomic or homuncular rules and was defined against controls. Results: Twelve patients (n = 12) were studied. Six had focal cortical dysplasia, two had polymicrogyria and schizencephaly, and four had isolated polymicrogyria. In the patients with cortical dysplasias, the somatosensory cortices were identified outside the rolandic area. In the two patients with polymicrogyria and schizencephaly, the somatosensory cortices remained in the rolandic areas as long as the anatomy was not distorted by the presence of the schizencephalic cleft. In the patients with isolated polymicrogyria, the somatosensory cortex was mapped without evidence of reorganization. Conclusion: In patients with epileptic MCDs involving rolandic and calcarine regions, cortical function may be reorganized if the MCDs are due to an abnormal neuronal or glial proliferation (i.e., cortical dysplasia) but may not be in MCDs caused by abnormal cortical organization (i.e., polymicrogyria).

意大利Hailey-Hailey病患者ATP2C1基因突变分析

Hailey-Hailey disease (HHD) is a rare autosomal dominant disorder characterized by recurrent skin lesions predominantly involving the body folds. It is caused by heterozygous mutations in the ATP2C1 gene, encoding the human secretory pathway Ca2+ /Mn2+ - ATPase protein 1 (hSPCA1). In this report we describe the molecular studies performed in eight HHD cases from Italy that led us to identify six different mutations scattered through the ATP2C1 gene in seven of eight cases. Four of the detected mutations were novel. Our results confirm the high allelic heterogeneity of the ATP2C1 gene and support the notion that HHD is a genetically homogeneous disorder. Furthermore, we created a table summarizing all previously reported ATP2C1 mutations, adapting the nomenclature, if needed, according to the guidelines of the Human Genome Variation Society.

瑞典北部山区亚北极区湖泊的汞污染趋势

尽管有关汞污染的研究已有多年,然而涉及欧洲高纬度区域的数据非常有限,尤其是长期时间趋势的研究。高纬度汞负荷是遵循欧洲近期下降的汞排放趋势,还是因持续的全球排放负荷仍然很高,尚不清楚。本研究利用位于瑞典山区北极圈以北12个湖泊的沉积物,评价过去和近来尤其是近200年来的汞污染状况。在19世纪后期或20世纪初期沉积的沉积物中明显增大的汞负荷在1960～1990年间达到峰值。此峰值代表超过背景浓度1.4～4.2倍的富集状态。此富集状态与低纬度和北极其它区域沉积物的富集状态相当。自20世纪90年代以来,12个湖泊中的8个湖泊的汞浓度已下降,与欧洲的排放趋势相似。

Evolutionary mechanism and frequency response of graphite electrode at extreme temperatures

The battery management system is employed to monitor the external temperature of the lithium-ion battery in order to detect any potential overheating.However,this outside–in detection method often suffers from a lag and is therefore unable to accurately predict the battery’s real-time state.Herein,an inside–out frequency response approach is used to accurately monitor the battery’s state at various temperatures in real-time and correlate it with the solid electrolyte interphase(SEI)evolution of the graphite electrode.The SEI evolution at temperatures of−15,25,60,and 90℃exhibits certain regular characteristics with temperature change.At a temperature of−15℃,the Li^(+)-solvent interaction of lithium-ion slowed down,resulting in a significant reduction in performance.At 25℃,a LiF-rich inorganic SEI was identified as forming,which facilitated lithium-ion transportation.However,high temperatures would induce decomposition of lithium hexafluorophosphate(LiPF_(6))and lithium-ion electrolyte.At the extreme temperature of 90℃,the SEI would be organic-rich,and Li_(x)P_(y)F_(z),a decomposition product of lithium salts,was further oxidized to Li_(x)PO_(y)F_(z),which led to a surge in the charge-transfer resistance at SEI(R_(sei))and a reduction in Coulombic efficiency(CE).This changing relationship can be recorded in real time from the inside out by electrochemical impedance spectroscopy(EIS)testing.This provides a new theoretical basis for the structural evolution of lithium-ion batteries and the regular characterization of EIS.

Environmental benefits for a geothermal power plant with CO_(2) reinjection:case study of the Kizildere 3 U1 geothermal power plant

Geothermal power plants(GPP)with high non condensable gases(NCG)content geothermal fluid have shown to be environmental impacting relating to their energy production,which could be critical if no corrective actions are achieved.The GPP of Kizildere 3 U1,located in Türkiye(Denizli),in where the geothermal fluid contains high percentage of CO_(2),99%of the NCG fraction,which represents the 3%of the geothermal fluid mass,is taken as a relevant case study to implement a new innovation consisting of NCG reinjection to reduce the amount of NCGs released to the atmosphere.In order to calculate the present environmental impacts which the plant is causing(baseline);and the potential reduction of environmental impacts which can be achieved with the innovation(reinjection),a life cycle assessment(LCA)calculation were developed.Primary data were collected for all the relevant stages of the energy conversion cycle and complemented where necessary with secondary data from other geothermal power plants studies.The main results of the baseline environmental assessment show that the construction phase is the most impacting phase due to the materials used in the power plant building construction,electrical generation equipment and distributed machinery and infrastructures;the effects in the operation phase are dominated by the geothermal fluid composition.In this sense,the application of CO_(2) reinjection at the Turkish site into the reservoir will prevent the emission of 1,700 tons⋅year1 in the pilot site and 10%of the total emissions released along the life span of the GPP.

Quantitative determination of the electron beam radiation dose for SARS-CoV-2 inactivation to decontaminate frozen food packaging

The spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) from cold-chain foods to frontline workers poses a serious public health threat during the current global pandemic. There is an urgent need to design concise approaches for effective virus inactivation under different physicochemical conditions to reduce the risk of contagion through viral contaminated surfaces of cold-chain foods. By employing a time course of electron beam exposure to a high titer of SARS-CoV-2 at cold-chain temperatures, a radiation dose of 2 kGy was demonstrated to reduce the viral titer from 10^(4.5)to 0 median tissue culture infectious dose(TCID_(50))/mL. Next,using human coronavirus OC43(HCoV-OC43) as a suitable SARS-CoV-2 surrogate, 3 kGy of high-energy electron radiation was defined as the inactivation dose for a titer reduction of more than 4 log units on tested packaging materials. Furthermore, quantitative reverse transcription PCR(RT-qPCR) was used to test three viral genes,namely, E, N, and ORF1ab. There was a strong correlation between TCID50and RT-qPCR for SARS-CoV-2detection. However, RT-qPCR could not differentiate between the infectivity of the radiation-inactivated and nonirradiated control viruses. As the defined radiation dose for effective viral inactivation fell far below the upper safe dose limit for food processing, our results provide a basis for designing radiation-based approaches for the decontamination of SARS-CoV-2 in frozen food products. We further demonstrate that cell-based virus assays are essential to evaluate the SARS-CoV-2 inactivation efficiency for the decontaminating strategies.

Physical multimorbidity patterns and depressive symptoms:a nationwide cross-sectional study in Japan

Objective The associations of physical multimorbidity with depressive symptoms have been investigated in a number of studies.However,whether patterns of chronic physical conditions have comparatively different associations with depressive symptoms remains unclear.This study aimed to investigate the associations of physical multimorbidity patterns with depressive symptoms.Design This study was designed as a nationwide cross-sectional survey in Japan.setting General sample of the Japanese population.Participants Adult Japanese residents were selected by a quota sampling method.Data were analysed from 1788 residents who reported one or more chronic health conditions.results Among four physical multimorbidity patterns:cardiovascular-renal metabolic(CRM),skeletal-articular digestive(SAD),respiratory-dermal(RDE)and malignant-digestive urologic(MDU),multivariable logistic regression analyses revealed that the RDE pattern showed the strongest association with depressive symptoms(aOR=1.68,95%CI:1.21 to 2.31 for the pattern score highest quartile,compared with the lowest quartile),followed by SAD and MDU patterns(aOR=1.41,95%CI:1.01 to 1.98 for the SAD pattern score highest quartile;1.41,95%CI:1.01 to 1.96 for the MDU pattern score highest quartile,compared with the lowest quartile).In contrast,the CRM pattern score was not significantly associated with depressive symptoms(aOR=1.31,95%CI:0.90 to 1.89 for the pattern score highest quartile,compared with the lowest quartile).Conclusions Physical multimorbidity patterns have different associations with depressive symptoms.Among these patterns,patients with the RDE pattern may be at a higher risk for developing depressive symptoms.This study reinforces the evidence that cluster pattern of chronic health conditions is a useful measure for clinical management of multimorbidity as it is differently associated with mental health status,which is one of the crucial outcomes for multimorbid patients.

A Crystallization Study of Nanocrystalline PZT 53/47 Granular Arrays Using a Sol-Gel Based Precursor

In this work,we intend to perform a detailed study on the crystallization process of PZT 53/47 nanostructured powders by starting out with an amorphous precursor synthesized by a sol-gel based solution.Our interests also lie in the feasibility for controlling the average grain size of the final structure in the submicron range on an ab initio basis.Purposely,Fourier transform infrared spectroscopy（FT-IR）,Raman（Stokes and Anti-Stokes）,X-ray diffraction（XRD） and scanning electron microscopy（SEM） are used to examine the microstructural characteristics based on previously reported differential thermal analysis/thermal gravimetric analysis（DTA/TGA） data.The results show a crystallization temperature of 800℃ to attain pure perovskite phase with excellent morphological quality,average grain size 〈DG〉〈 300 nm and with average crystallite size 〈DC〉〈15 nm.

缩量背后

进入6月以后,杭州主城区商品房成交量锐减,据透明售房网的数据显示,截至7月底,杭州主城区的新房成交量已连续八周下滑!这一数据多少引起了市场的一些恐慌。业内人士普遍认为上半年成交量的井喷是压抑已久的刚性需求的集中释放和改善型需求大量入市的结果,那么连续八周的成交量萎缩,意味着刚需的收手?改善型需求的掉头?抑或是市场整体出现了逆转?成交量的萎缩是相对的,6、7月份依然实现了8970、4230套的成交量,相比去年,这样的成绩已经十分可观了。究竟是什么户型、哪些区域成为了成交量下降的主力?而又是哪些人在成交量减少之余继续出手?我们试图探究萎缩背后更深层次的信息,来帮助购房者在动荡的市场中作出更为理性的抉择。

Thermally Conductive Study of Polyethylene/Al2O3 Composite Networks Cross-linked by Electron Beam Irradiation

The surface-modifled Al2O3 particles were introduced into polyethylene(PE)to enhance the thermal conductivity,and PE/Al2O3 cross-linked networks with improved thermal and mechanical properties were prepared through electron beam(EB)irradiation technology.The incorporation of reactive irradiation sensitizer was useful in fabricating a high degree of cross-linking(DC)PE networks under a low irradiation dose.In the PE sample containing 2%sensitizer,DC ca.67.1%could be obtained under 60 kGy(1 kGy=1000 J/kg).EB-irradiation greatly improved thetensile stress of PE-based samples,and the tensile stresses of the samples with 0.2—5%TMPTA(trimethylolpr pane triacrvlate)under 60 kGy were 24.61—27.77 MPa.All the EB-irradiated samples had higher Vicat softening temperatures than the samples without irradiation.After treatment at 120 kGy,the Vicat softening temperatures of PE-Al2O3-44/TMPTA-2 increased from 127℃to 130.4℃.SEM images revealed that PE-Al2O3-5O samples with increased amount of Al2O3 particles showed a conduction"pathway,"and thennal conductivity reached 0.67 W/(m·K).Thus,high-performance pipes were extruded,which could satisfy the static hydraulic blasting test and exhibit improved thennal conduction capability.