目的:评价藏医放血疗法对急性痛风局部NLRP3、S100A8/A9和白细胞介素1β(interleukin-1β,IL-1β)的影响。方法:选取急性痛风患者30例,采取藏医放血疗法治疗,取放血局部最初及一次性放血量达到30、60、90 m L的患者放血部位血液各5 m L...目的:评价藏医放血疗法对急性痛风局部NLRP3、S100A8/A9和白细胞介素1β(interleukin-1β,IL-1β)的影响。方法:选取急性痛风患者30例,采取藏医放血疗法治疗,取放血局部最初及一次性放血量达到30、60、90 m L的患者放血部位血液各5 m L,检测IL-1β、NLRP3、TGF-β、S100A8/A9及血UA水平。结果:放血后局部IL-1β、S100A8/A9呈逐渐下降趋势,TGF-β、NLRP3呈逐渐上升趋势,放血90 mL时与放血0 mL时IL-1β、TGF-β、S100A8/A9和NLRP3水平均存在统计学差异(P<0.01)。放血过程中局部IL-1β和NLRP3存在相关性;局部IL-1β和S100A8/A9 90 mL时两者存在弱正相关;局部IL-1β和TGF-β无明显负相关性。结论:MSU下降可直接导致IL-β水平下降,随着放血量的继续增加,包括巨噬细胞表型转化在内的其他因素所发挥的降低IL-β作用可能增强,提示放血疗法不仅仅通过单一机制发挥作用,可能是多种途径共同作用的结果。展开更多
Extreme environments like active volcanoes exhibit many difficulties in being studied by in situ techniques. For example, during eruptions, summit areas are very hard to be accessed because of logistics problems and/o...Extreme environments like active volcanoes exhibit many difficulties in being studied by in situ techniques. For example, during eruptions, summit areas are very hard to be accessed because of logistics problems and/or volcanic hazards. The use of remote sensing techniques in the last 20 years by satellite or airborne platforms has proven their capabilities in mapping and monitoring the evolution of volcanic activity. This approach has become increasingly important, as much interest is actually focused on understanding precursory signals to volcanic eruptions. In this work we verify the use of cutting-edge technology like unmanned flying system thermally equipped for volcanic applications. We present the results of a flight test performed by INGV in collaboration with the University of Bologna (Aerospace Division) by using a multi-rotor aircraft in a hexacopter configuration. The experiment was realized in radio controlled mode to overcome many regulation problems which, especially in Italy, limit the use of this system in autonomous mode. The overall goal was not only qualitative but also quantitative oriented. The system flew above an Italian mud volcano, named Le Salinelle, located on the lower South West flank of Mt. Etna volcano, which was chosen as representative site, providing not only a discrimination between hot and cold areas, but also the corresponding temperature values. The in-flight measurements have been cross-validated with contemporaneous in-situ acquisition of thermal data and from independent measurements of mud/water temperature.展开更多
文摘目的:评价藏医放血疗法对急性痛风局部NLRP3、S100A8/A9和白细胞介素1β(interleukin-1β,IL-1β)的影响。方法:选取急性痛风患者30例,采取藏医放血疗法治疗,取放血局部最初及一次性放血量达到30、60、90 m L的患者放血部位血液各5 m L,检测IL-1β、NLRP3、TGF-β、S100A8/A9及血UA水平。结果:放血后局部IL-1β、S100A8/A9呈逐渐下降趋势,TGF-β、NLRP3呈逐渐上升趋势,放血90 mL时与放血0 mL时IL-1β、TGF-β、S100A8/A9和NLRP3水平均存在统计学差异(P<0.01)。放血过程中局部IL-1β和NLRP3存在相关性;局部IL-1β和S100A8/A9 90 mL时两者存在弱正相关;局部IL-1β和TGF-β无明显负相关性。结论:MSU下降可直接导致IL-β水平下降,随着放血量的继续增加,包括巨噬细胞表型转化在内的其他因素所发挥的降低IL-β作用可能增强,提示放血疗法不仅仅通过单一机制发挥作用,可能是多种途径共同作用的结果。
文摘Extreme environments like active volcanoes exhibit many difficulties in being studied by in situ techniques. For example, during eruptions, summit areas are very hard to be accessed because of logistics problems and/or volcanic hazards. The use of remote sensing techniques in the last 20 years by satellite or airborne platforms has proven their capabilities in mapping and monitoring the evolution of volcanic activity. This approach has become increasingly important, as much interest is actually focused on understanding precursory signals to volcanic eruptions. In this work we verify the use of cutting-edge technology like unmanned flying system thermally equipped for volcanic applications. We present the results of a flight test performed by INGV in collaboration with the University of Bologna (Aerospace Division) by using a multi-rotor aircraft in a hexacopter configuration. The experiment was realized in radio controlled mode to overcome many regulation problems which, especially in Italy, limit the use of this system in autonomous mode. The overall goal was not only qualitative but also quantitative oriented. The system flew above an Italian mud volcano, named Le Salinelle, located on the lower South West flank of Mt. Etna volcano, which was chosen as representative site, providing not only a discrimination between hot and cold areas, but also the corresponding temperature values. The in-flight measurements have been cross-validated with contemporaneous in-situ acquisition of thermal data and from independent measurements of mud/water temperature.
