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Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease 被引量:11
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作者 Flavia A Cimini Ilaria Barchetta +5 位作者 Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini 《World Journal of Gastroenterology》 SCIE CAS 2017年第19期3407-3417,共11页
Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological ... Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the"multiple parallel hits"theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. 展开更多
关键词 Adipose tissue dysfunction Vitamin D Non-alcoholic fatty liver disease STEATOSIS Non-alcoholic steatohepatitis OBESITY ADIPOKINES
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Revascularization for Iliac-femoral Artery Pseudoaneurysm with Greater Saphenous Vein 被引量:4
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作者 Ji-dong Wu Yue-hong Zheng +1 位作者 Nim Choi Furtado Rui 《Chinese Medical Sciences Journal》 CAS CSCD 2010年第1期57-60,共4页
Objective To investigate the role of revascularization procedures with autologous greater saphenous vein in surgical management of iliac-femoral artery pseudoaneurysm in parenteral drug abusers. Methods Twenty-one pat... Objective To investigate the role of revascularization procedures with autologous greater saphenous vein in surgical management of iliac-femoral artery pseudoaneurysm in parenteral drug abusers. Methods Twenty-one patients with iliac-femoral artery pseudoaneurysm caused by parenteral drug abuse from 2004 to 2007 were enrolled. Among them,15 patients were male and 6 were female; their average age was 31.3 years. The size of pseudoaneurysms ranged from 3.0 cm to 7.5 cm. Common femoral artery and distal external iliac artery were often involved. We performed arterial reconstruction on these patients with autologous greater saphenous vein as a graft after excising iliac-femoral artery pseudoaneurysm through a single curved inguinal incision. All patients were followed up,and the complications were recorded. Results The surgical procedures were finished without intraoperative mortality or perioperative complications. All patients were free of claudication symptoms after the surgery except one case with preoperative popliteal artery stenosis. One case of infection and wound tissue fistula was found later. One case had inguinal incisional hematoma and another complained of numbness in thigh skin. Conclusions The use of autologous greater saphenous venous grafts for arterial reconstruction after pseudoaneurysm excision in drug abusers is safe and effective. This technique offers more advantages than arterial ligation alone without revascularization. An optimal greater saphenous venous graft is a prerequisite for revascularization. 展开更多
关键词 PSEUDOANEURYSM drug abuser BYPASS greater saphenous vein
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The Application of BP Neural Networks to Analysis the National Vulnerability 被引量:1
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作者 Guodong Zhao Yuewei Zhang +2 位作者 Yiqi Shi Haiyan Lan Qing Yang 《Computers, Materials & Continua》 SCIE EI 2019年第2期421-436,共16页
Climate change is the main factor affecting the country’s vulnerability,meanwhile,it is also a complicated and nonlinear dynamic system.In order to solve this complex problem,this paper first uses the analytic hierar... Climate change is the main factor affecting the country’s vulnerability,meanwhile,it is also a complicated and nonlinear dynamic system.In order to solve this complex problem,this paper first uses the analytic hierarchy process(AHP)and natural breakpoint method(NBM)to implement an AHP-NBM comprehensive evaluation model to assess the national vulnerability.By using ArcGIS,national vulnerability scores are classified and the country’s vulnerability is divided into three levels:fragile,vulnerable,and stable.Then,a BP neural network prediction model which is based on multivariate linear regression is used to predict the critical point of vulnerability.The function of the critical point of vulnerability and time is established through multiple linear regression analysis to obtain the regression equation.And the proportion of each factor in the equation is established by using the partial least-squares regression to select the main factors affecting the country’s vulnerability,and using the neural network algorithm to perform the fitting.Lastly,the BP neural network prediction model is optimized by genetic algorithm to get the chaotic time series BP neural network prediction model.In order to verify the practicability of the model,Cambodia is selected to be an example to analyze the critical point of the national vulnerability index. 展开更多
关键词 Climate change BP neural networks national vulnerability GA-BP
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Case study scenarios in site selection of hazardous material facilities based on transportation preferences 被引量:1
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作者 Babak Mehran Musharraf Ahmad Khan +2 位作者 Mina Mehran Hyukjae Roh Satish Sharma 《Journal of Modern Transportation》 2019年第4期317-333,共17页
A methodology is proposed to evaluate and rank potential sites for facilities dealing with hazardous materials(HAZMAT).The proposed methodology incorporates HAZMAT route planning into facility siting while considering... A methodology is proposed to evaluate and rank potential sites for facilities dealing with hazardous materials(HAZMAT).The proposed methodology incorporates HAZMAT route planning into facility siting while considering transportation preferences and challenges.The area of interest is divided into smaller zones representing potential sites for a HAZMAT facility.A multimodal transportation network including railways and roads is considered for transportation of HAZMAT.Each zone is evaluated based on its accessibility from a set of selected points of interests(POIs),which are defined as potential origin/destination points for transportation of HAZMAT.The shortest routes between each POI and potential zones are evaluated based on a cost function which can accommodate multiple criteria to determine the associated disutility for each potential zone.Finally,zones are ranked based on their cumulative disutility scores.The proposed analysis method is quantitative,and at the same time it is adequately flexible to allow inclusion of subjective criteria.Application of the proposed methodology is demonstrated for identifying optimal locations for a HAZMAT facility(e.g.,a nuclear facility)using the Canadian province of Saskatchewan as an example.Three scenarios were evaluated including(1)all network segments and POIs were treated equally,(2)network segments were rank ordered based on their functional classification while POIs were treated equally and(3)network segments were rank ordered based on their functional classification with preferences given to specific POI(s). 展开更多
关键词 HAZMAT TRANSPORTATION SITE selection ROUTE PLANNING Shortest PATH analysis
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一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文) 被引量:6
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作者 Barbano R Palumbo O +13 位作者 Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 《中华神经外科疾病研究杂志》 CAS 2014年第5期433-433,共1页
Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nat... Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. 展开更多
关键词 神经外科学 疾病 临床研究 医学
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监管科学发展下药品审批提效的实践探讨 被引量:2
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作者 王刚 曾亚莉 +3 位作者 雷灿 黄庭颖 Magda Bujar Ting Wang 《中国食品药品监管》 2021年第7期34-41,共8页
药品监管科学研究在最近10年取得了长足的发展。不管是从研究论文的产出,还是监管机构的法规以及指南文件的及时发布,均体现了顺应当前科技发展的需求。面对持续增长的审评压力,监管机构在资源有限的情况下,通过设置监管促进路径、开启... 药品监管科学研究在最近10年取得了长足的发展。不管是从研究论文的产出,还是监管机构的法规以及指南文件的及时发布,均体现了顺应当前科技发展的需求。面对持续增长的审评压力,监管机构在资源有限的情况下,通过设置监管促进路径、开启共享审评模式等方式,提高审评效率,加速新药上市。展望未来的药品审评审批发展,将始终坚持以患者为中心的宗旨,全面考虑和平衡多个利益相关方的诉求,从而真正加速并优化创新产品从法规审评到患者可及的全流程。 展开更多
关键词 监管审评 监管科学 共享审评模式 监管促进路径 卫生技术评估
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Thoraco-abdominal Aorta Revascularization through a Retroperitoneal Approach 被引量:1
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作者 Yue-hong Zheng Kun Yu +3 位作者 Jie-feng Zhang Nim Choi Hong-ru Deng Furtado Rui 《Chinese Medical Sciences Journal》 CAS CSCD 2010年第4期233-236,共4页
Objective To investigate the application of the retroperitoneal approach in aortic surgery. Methods We collected and analyzed data of 7 patients in Macao who presented with aortic diseases from 2007 to 2008 and were t... Objective To investigate the application of the retroperitoneal approach in aortic surgery. Methods We collected and analyzed data of 7 patients in Macao who presented with aortic diseases from 2007 to 2008 and were treated with aorta repair through retroperitoneal approach. Demographic features as well as intraoperative and postoperative data were analyzed. One case of thoracoabdominal aneurysm and 4 cases of abdominal aneurysm received artificial graft, among which hybrid iliac artery reconstruction with Zenith stent covering the ostium of the left subclavian artery was performed in 2 cases of infrarenal abdominal aneurysm. Aortic-iliac artery bypass was performed in 2 cases of aortoiliac occlusion. Results No operative or early postoperative death was observed. No perioperative intestinal adhesion or ureteral obstruction was found. One case reported delayed paraplegia and graft infection as postoperative complications. The complications were partially removed 3 months later after rehabilitation. Conclusion Retroperitoneal approach is a safe and feasible technique, which associated with a low incidence of postoperative pulmonary complications. 展开更多
关键词 AORTA retroperitoneal approach REVASCULARIZATION
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聚焦加速审评通道和国际化——2010~2019年国外六大监管机构新药审批情况分析 被引量:1
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作者 Celine Rodier Magda Bujar 曾亚莉(编译) 《中国食品药品监管》 2020年第9期54-71,共18页
本文介绍了国际监管科学创新研究中心(CIRS)对六大监管机构批准的新活性物质(NAS)的年度分析结果,对2010~2019年情况进行回顾,重点介绍了2019年六大监管机构NAS批准情况和关注的2个因素,即加速审评通道(FRP)和基于企业为确保能够在全球... 本文介绍了国际监管科学创新研究中心(CIRS)对六大监管机构批准的新活性物质(NAS)的年度分析结果,对2010~2019年情况进行回顾,重点介绍了2019年六大监管机构NAS批准情况和关注的2个因素,即加速审评通道(FRP)和基于企业为确保能够在全球范围内及时供应药品制定的申报策略而实施的药物国际化进程,以期为新药审评审批提供参考。 展开更多
关键词 新活性物质 监管 加速审评 EMA FDA
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监测国际人用药品注册技术协调会(ICH)指南的执行和落实情况——2021年项目报告 被引量:1
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作者 Juan Lara Magda Bujar 曾亚莉 《中国食品药品监管》 2022年第6期92-107,共16页
本研究通过国际监管科学创新中心(CIRS)与国际人用药品注册技术协调会(ICH)合作开发并定义的在线调研问卷,监测并评估ICH非常任、非创始的监管机构成员对ICH二、三级指南,以及ICH观察员对ICH一级指南的执行和落实情况,重点介绍ICH指南... 本研究通过国际监管科学创新中心(CIRS)与国际人用药品注册技术协调会(ICH)合作开发并定义的在线调研问卷,监测并评估ICH非常任、非创始的监管机构成员对ICH二、三级指南,以及ICH观察员对ICH一级指南的执行和落实情况,重点介绍ICH指南执行和落实情况评估结果、主要监管机构成员和ICH观察员的自我评估,以及跨国制药公司对各监管机构执行情况的反馈。研究结果表明,各参与研究的监管机构对ICH指南的执行和落实程度非常高,制药企业看法与监管机构自我评估结果一致。 展开更多
关键词 ICH 监管 指南 执行
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U-Pb SHRIMP-II Baddeleyite and Zircon Dating of the Early Proterozoic Monchegorsk Layered Mafite-Ultramafite Complex(Kola Peninsula): Evidence of Synchronous Magmatism
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作者 Nickolay V.Rodionov Anton A.Antonov +1 位作者 Boris V.Belyatsky Sergey A.Sergeev 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第S1期79-80,共2页
The Early Paleoproterozoic Monchegorsk Complex is exposed over an area of 550 km;and comprises two layered mafite–ultramafite intrusions:the Monchepluton of ultramafic and mafic rocks and the predominantly gabbroid
关键词 SHRIMP U-Pb SHRIMP-II Baddeleyite and Zircon Dating of the Early Proterozoic Monchegorsk Layered Mafite-Ultramafite Complex Pb Kola Peninsula Evidence of Synchronous Magmatism II
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2012~2021年国外六大监管机构新药审评情况分析:聚焦监管促进路径和国际化 被引量:1
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作者 Juan Lara Magda Bujar +1 位作者 Neil McAuslane 张颖(编译) 《中国食品药品监管》 2023年第6期12-29,共18页
本文介绍了国际监管科学创新中心(CIRS)对六大监管机构批准的新活性物质(NAS)的年度分析结果,重点分析了2021年NAS批准情况,并回顾了2012~2021年的情况。通过分析可以看出,尽管中位批准时间可以作为考量监管机构工作效率和药物获批上市... 本文介绍了国际监管科学创新中心(CIRS)对六大监管机构批准的新活性物质(NAS)的年度分析结果,重点分析了2021年NAS批准情况,并回顾了2012~2021年的情况。通过分析可以看出,尽管中位批准时间可以作为考量监管机构工作效率和药物获批上市所需时间的重要指标,但同时也需要考虑其他因素,包括监管促进路径(FRP)、NAS的国际化以及新数据来源[包括真实世界数据(RWD)]的使用等。 展开更多
关键词 监管机构 批准时间 监管促进路径
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Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines
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作者 Danielle Queiroz Calcagno Sylvia Santomi Takeno +10 位作者 Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Elizabeth Suchi Chen Taíssa Maíra Thomaz Araújo Eleonidas Moura Lima Maria Isabel Melaragno Samia Demachki Paulo Pimentel Assumpcao Rommel Rodriguez Burbano Marília Cardoso Smith 《World Journal of Gastroenterology》 SCIE CAS 2016年第43期9506-9514,共9页
AIM To identify common copy number alterations on gastric cancer cell lines.METHODS Four gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chromosomal comparative genome hybridization and array compar... AIM To identify common copy number alterations on gastric cancer cell lines.METHODS Four gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chromosomal comparative genome hybridization and array comparative genome hybridization. We also confirmed the results by fluorescence in situ hybridization analysis using the bacterial artificial chromosome clone and quantitative real time PCR analysis.RESULTS The amplification of 9p13.3 was detected in all cell lines by both methodologies. An increase in the copy number of 9p13.3 was also confirmed by fluorescence in situ hybridization analysis. Moreover, the interleukin 11 receptor alpha(IL11RA) and maternal embryonic leucine zipper kinase(MELK) genes, which are present in the 9p13.3 amplicon, revealed gains of the MELK gene in all the cell lines studied. Additionally, a gain in the copy number of IL11 RA and MELK was observed in 19.1%(13/68) and 55.9%(38/68) of primary gastric adenocarcinoma samples, respectively. CONCLUSION The characterization of a small gain region at 9p13.3 in gastric cancer cell lines and primary gastric adenocarcinoma samples has revealed MELK as a candidate target gene that is possibly related to the development of gastric cancer. 展开更多
关键词 IL11RA Gastric cancer Genomic profiling MELK 9p13.3
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韩国K-REACH监管扩容
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《中国洗涤用品工业》 2017年第3期96-96,98,100,共3页
2016年11月29号,为了全面审查和升级家用化学产品的安全性,韩国国家内阁委员会确定并且宣布K-REACH法规中正式加入"家用化学产品安全管理办法"。该办法主要针对公众健康有影响的家用化学产品并以此来预防类似加湿器杀菌剂等重大事故... 2016年11月29号,为了全面审查和升级家用化学产品的安全性,韩国国家内阁委员会确定并且宣布K-REACH法规中正式加入"家用化学产品安全管理办法"。该办法主要针对公众健康有影响的家用化学产品并以此来预防类似加湿器杀菌剂等重大事故发生。 展开更多
关键词 韩国 扩容 监管 化学产品 安全管理办法 事故发生 公众健康 安全性
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Analysis of Regulatory Policies and Registration/Record Keeping Status of Domestic Cosmetics in China
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作者 CIRS 《China Detergent & Cosmetics》 2018年第2期54-56,共3页
On December 5,2017,CFDA issued a notice on regulating cosmetics registration and filing application(Decree No.195,2017),in order to ensure that the company information on the new version of Cosmetics Production Licens... On December 5,2017,CFDA issued a notice on regulating cosmetics registration and filing application(Decree No.195,2017),in order to ensure that the company information on the new version of Cosmetics Production License and recorded products is consistent.For approved domestic special use cosmetics,the application for the change of company info is not required when the actual production place has no change,but should apply for the change when applying for 展开更多
关键词 化妆品行业 行业管理 发展现状 中国
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Latest Update of Cosmetic Regulations in China Since 2017
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作者 CIRS 《China Detergent & Cosmetics》 2018年第2期66-69,共4页
Great changes happened to Chinese cosmetics regulations in 2017. This article focuses on the latest update of cosmetics regulations in China since 2017 and assesses how those changes will impact the import of cosmetic... Great changes happened to Chinese cosmetics regulations in 2017. This article focuses on the latest update of cosmetics regulations in China since 2017 and assesses how those changes will impact the import of cosmetics to China.Data of registered or recorded cosmetics with CFDA or local FDAs Import cosmetics by 展开更多
关键词 化妆品行业 法律法规 发展现状 行业管理
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How to Comply with the Pilot Policy of China for the Import of Non-special Use Cosmetics
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作者 CIRS 《China Detergent & Cosmetics》 2018年第2期62-65,共4页
CIRS held a free webinar(download)on 26 and 27 Apr,2018 on How to Comply with the Pilot Policy of Expanding10 New Free Trade Zones(FTZs)for the Import of Nonspecial Use Cosmetics.The article includes 3 parts:1)General... CIRS held a free webinar(download)on 26 and 27 Apr,2018 on How to Comply with the Pilot Policy of Expanding10 New Free Trade Zones(FTZs)for the Import of Nonspecial Use Cosmetics.The article includes 3 parts:1)General info of pilot system in Shanghai Pudong new area and comparison with CFDA registration 2)Data analysis of record keeping in Pudong new area 3)Brief introduction and outlook of expanding 10 new free trade zones for the import of non-special use cosmetics. 展开更多
关键词 自由贸易区 中国 对外贸易 化工行业
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Intra-Domiciliary Transmission of Chagas’ Disease in Rural Areas of Yucatan Mexico
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作者 Eugenia Guzman-Marin Karla Y. Acosta-Viana +2 位作者 Marylin Puerto-Solís Antonio Ortega-Pacheco Matilde Jimenez-Coello 《Open Journal of Epidemiology》 2016年第4期244-255,共12页
With the objective to describe the relationship between T. cruzi infection in humans and sinantropic reservoir and vectors in the rural conditions a study was performed in municipalities of the Yucatan state in Mexico... With the objective to describe the relationship between T. cruzi infection in humans and sinantropic reservoir and vectors in the rural conditions a study was performed in municipalities of the Yucatan state in Mexico. Blood samples from humans, dogs and opossum were taken from the households. Vectors were also collected and the infection and infestation indexes were calculated. Serum samples were evaluated by indirect hemagglutination (IH) and indirect immunofluorescence (IFI) to determine IgG antibodies against Trypanosoma cruzi. The polymerase chain reaction (PCR) was also performed in the samples taken from humans and reservoirs. Blood smears were performed in reservoirs. Sampled humans underwent to an electrocardiographic study to identify functional and conduction alterations of the heart. Household building characteristics were noted. A total of 367 blood samples were collected from people. The presence of IgG antibodies was 16.6% and 71.0% at PCR. Electrocardiographic studies revealed that 31% of patients seropositive to T. cruzi have a medical condition. 20.0% of dogs were seropositive and 68.5 positive to PCR. At the direct detection 13.6% resulted positive. In opossum 29.1% were seropositive and 72.9% positive to PCR. A total of 269 triatomineos were captured and 52.7% were infected with T. cruzi. The infection and infestation index were 52.4% and 60.8% respectively. The presence of adult vectors and their nymph’s were more frequently found in households made with wattle roofs (45.2 and 73.9 % respectively) than other kind of building materials. Electrocardiographic abnormalities found in positive persons were: Incomplete right bundle branch block (55%), tachycardia (35%), old myocardial infarction (5%) and incomplete block of the left bundle (5%). This work highlights the importance of comprehensive studies on the transmission of T. cruzi in the Yucatan where the link between human infection in synanthropic reservoirs and vectors is established. This information is important to design programs for the epidemiological surveillance and control to break the chain of transmission of the disease. 展开更多
关键词 Trypanosoma cruzi VECTORS SEROLOGY PCR Zoonosis.
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拉坦前列素-噻吗心安联合用药与单用拉坦前列素24h眼压控制效果比较
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作者 Konstas A.G.P Boboridis K +2 位作者 Tzetzi D W.C. Stewart 潘佳鸿 《世界核心医学期刊文摘(眼科学分册)》 2005年第12期32-32,共1页
Objective: To evaluate the 24- hour efficacy and safety of the latanoprost-timolol maleate-fixed combination vs latanoprost therapy in patients with primary open-angle glaucoma. Methods: A prospective, observer-masked... Objective: To evaluate the 24- hour efficacy and safety of the latanoprost-timolol maleate-fixed combination vs latanoprost therapy in patients with primary open-angle glaucoma. Methods: A prospective, observer-masked, crossover, activecontrolled, randomized comparison in which after a 6- week medicine-free period, patients were randomized to either latanoprost-timolol-fixed combination therapy or latanoprost therapy, both dosed once each evening, alone for 8 weeks. Patients were then switched to the opposite treatment for 8 weeks. At the end of the washout and treatment periods, a 24- hour diurnal curve was performed. Results: The baseline untreated mean± SD diurnal curve in 37 patients who completed the study was 24.2± 2.0 mm Hg. The mean diurnal curve was 19.2± 2.6 mm Hg for those who received latanoprost therapy alone and 16.7 ± 2.1 mm Hg for those who received the fixed combination therapy (P<.001). The fixed combination therapy also provided a lower absolute intraocular pressure level (1.5- 2.9 mm Hg, P<.001) and a greater intraocular pressure reduction from the untreated baseline (P<.001). Stinging was statistically lower with latanoprost therapy alone (P=.04), but itching was statistically increased compared with the fixed combination therapy (P=.04). Conclusion: The result of this study suggests that the latanoprost-timolol-fixed combination compared with latanoprost therapy alone provides improved intraocular pressure reduction over the 24- hour diurnal curve and for each individual time point in patients with primary open-angle glaucoma. 展开更多
关键词 拉坦 噻吗心安 眼压控制 联合用药 眼压下降 眼压值 洗脱期 瘙痒感 刺激症状 盲法
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依那西普联合标准疗法治疗Wegener肉芽肿
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作者 Stone J.H. 郭战宏 《世界核心医学期刊文摘(心脏病学分册)》 2005年第6期27-27,共1页
BACKGROUND: The majority of patients with Wegener’s granulomatosis have disease flares after conventional medications are tapered. There is no consistently safe, effective treatment for the maintenance of remission. ... BACKGROUND: The majority of patients with Wegener’s granulomatosis have disease flares after conventional medications are tapered. There is no consistently safe, effective treatment for the maintenance of remission. METHODS: We conducted a randomized, placebo-controlled trial at eight centers to evaluate etanercept for the maintenance of remission in 180 patients with Wegener’s granulomatosis. The primary outcome was sustained remission, defined as a Birmingham Vasculitis Activity Score for Wegener’s Granulomatosis of 0 for at least six months(scores can range from 0 to 67, with higher scores indicating more active disease). In addition to etanercept or placebo, patients received standard therapy(glucocorticoids plus cyclophosphamide or methotrexate). After remission, standard medications were tapered according to the protocol. RESULTS: The mean follow-up for the overall cohort was 27 months. Of the 174 patients who could be evaluated, 126(72.4 percent) had a sustained remission, but only 86(49.4 percent) remained in remission for the remainder of the trial. There were no significant differences between the etanercept and control groups in the rates of sustained remission(69.7 percent vs. 75.3 percent, P=0.39), sustained periods of low-level disease activity(86.5 percent vs. 90.6 percent, P=0.32), or the time required to achieve those measures. Disease flares were common in both groups, with 118 flares in the etanercept group(23 severe and 95 limited) and 134 in the control group(25 severe and 109 limited). There was no significant difference between the etanercept and control groups in the relative risk of disease flares per 100 person-years of follow-up(0.89, P=0.54). During the study, 56.2 percent of patients in the etanercept group and 57.1 percent of those in the control group had at least one severe or life-threatening adverse event or died(P=0.90). Solid cancers developed in six patients in the etanercept group, as compared with none in the control group(P=0.01). CONCLUSIONS: Etanercept is not effective for the maintenance of remission in patients with Wegener’s granulomatosis. Durable remissions were achieved in only a minority of the patients, and there was a high rate of treatment-related complications. 展开更多
关键词 WEGENER 依那西普 疾病活动性 血管炎 氨甲蝶呤 安慰剂对照 实体性肿瘤 糖皮质激素 研究中心 持续时间
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人单核细胞埃里希体病
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作者 Stone J.H. Dierberg K. +2 位作者 Aram G. Dumler J. S. 王亭忠 《世界核心医学期刊文摘(心脏病学分册)》 2005年第4期17-18,共2页
A 56-year-old man with a history of Wegener granulomatosis presented with 6 days of sinus congestion, fever, malaise, myalgias, episcleritis, and a morbilli form rash. An exacerbation of Wegener granulomatosis was the... A 56-year-old man with a history of Wegener granulomatosis presented with 6 days of sinus congestion, fever, malaise, myalgias, episcleritis, and a morbilli form rash. An exacerbation of Wegener granulomatosis was the principal concern because of the frequency of flares in that disease. The patient developed acute r enal failure, thrombocytopenia, transaminitis, and, finally, severe myocarditis that led to congestive heart failure. Additional history-taking and the evoluti on of his clinical features led to empirical treatment with doxycycline for huma n monocytic ehrlichiosis(HME). The diagnosis of HME was confirmed by both a poly merase chain reaction assay for Ehrlichia chaffeensis and by the demonstration of morulae within peripheral blood mononuclear cells. The patient improved prompt ly followinginstitution of doxycycline, and his cardiac function returned to nor mal over a period of 4 months. 展开更多
关键词 人单核细胞 埃里希体病 韦格纳肉芽肿 麻疹样疹 巩膜外层炎 脱氧土霉素 经验性治疗 急性心力衰竭 外周血单核细胞 肌痛
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