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O-GlcNAcylation regulates phagocytosis by promoting Ezrin localization at the cell cortex 被引量:1
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作者 Song Yang Hanyu Liu +5 位作者 Hua Ni Lingyu Jiang Mulin Yang Quan Chen Jun Zhou Fan Yu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2023年第7期486-496,共11页
O-GlcNAcylation is a post-translational modification that serves as a cellular nutrient sensor and participates in multiple physiological and pathological processes.However,it remains uncertain whether O-GlcNAcylation... O-GlcNAcylation is a post-translational modification that serves as a cellular nutrient sensor and participates in multiple physiological and pathological processes.However,it remains uncertain whether O-GlcNAcylation is involved in the regulation of phagocytosis.Here,we demonstrate a rapid increase in protein OGlcNAcylation in response to phagocytotic stimuli.Knockout of the O-GlcNAc transferase or pharmacological inhibition of O-GlcNAcylation dramatically blocks phagocytosis,resulting in the disruption of retinal structure and function.Mechanistic studies reveal that the O-GlcNAc transferase interacts with Ezrin,a membrane-cytoskeleton linker protein,to catalyze its O-GlcNAcylation.Our data further show that Ezrin OGlcNAcylation promotes its localization to the cell cortex,thereby stimulating the membrane-cytoskeleton interaction needed for efficient phagocytosis.These findings identify a previously unrecognized role for protein O-GlcNAcylation in phagocytosis with important implications in both health and diseases. 展开更多
关键词 O-GLCNACYLATION PHAGOCYTOSIS Retinal pigment epithelium EZRIN CYTOSKELETON
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