Knowledge towards Physical Medicine and Rehabilitation among Training Doctors and Medical Students at the Mohammed VI University Hospital of Marrakech

The aim of our study is to evaluate the knowledge regarding physical medicine and rehabilitation among physicians in training and medical students at the Mohammed VI University Hospital in Marrakech, to approach the knowledge, attitudes, and practices of doctors regarding physical medicine and rehabilitation and evaluate the knowledge in theoretical training related to PRM among the students. We conducted a monocentric cross-sectional analytical study, using a web-based anonymous survey, carried out among 558 undergraduate student and training doctors, randomly selected in the form of a survey on the knowledge towards Physical Medicine and rehabilitation. We received 558 survey duly completed by students of the Faculty of Medicine and Pharmacy of Marrakech (62.4%) and training doctors (37.6%). The mean age of the participants was 24.53 ± 3.9 years, with extremes ranging from 17 to 39 years. 52.7% of the participants were from the former educational reform, The predominance of participation was remarkable among pediatricians 23%, The population who knew PRM was the majority (79.3%), 40.7% of the participants were unaware of the availability of a PRM department at Mohamed VI University Hospital, 0.5% of all training doctors and medical students questioned strongly agreed with the sufficiency of their training in disability management were belonging to the new reform, 84.1% of participants had never attended or referred a patient to the PRM department. 23.2% of training doctors affirmed the referral of patients to PRM for further management. Despite the essential role of PRM in the management of diseases, it remains little known by training doctors and medical students. This lack of knowledge of PRM reflects the lack of the undergraduate and postgraduate of the medical education in the field of rehabilitation.

Is There a Relationship between COVID-19 Infection and the Occurrence of Anencephaly? Observation of the Maternity of Mohammed the VI University Hospital of Marrakech

Introduction: Morocco has experienced, like the whole world, the COVID-19 pandemic. Until the writing of this article, a subjective observation of the increase in the number of anencephaly has been observed in our facility. And since the teratogenic potential of the SARS Cov 2 virus is not sufficiently documented, we wondered if there would be a relationship between the relatively high number of anencephalic fetuses and COVID-19 infection. Aim: the objective of the study is to look for a possible correlation between the period of conception of these anencephalies and the pandemic. Material and methods: This is a retrospective study (from June 1, 2020 to May 31, 2022 in the Obstetrics Gynecology department, Faculty of Medicine and Pharmacy, CADI AYYAD UNIVERSITY Marrakech Morocco) consisting of the analysis of the number of patients in the target embryonic period (namely the closure of the neural tube: D18 to D30 of embryonic life) compared to the reference curves of the evolution of the SARS Cov2 pandemic. Results: The analysis of the number of patients at the target embryonic phase shows that many of our anencephalons (63%) were conceived during periods of high diffusion of the SARS Cov 2 virus in Morocco. Conclusion: Our study suggests a relationship between the COVID-19 pandemic and the occurrence of anencephaly, we cannot, however, highlight the type of direct or indirect relationship that binds them. Therefore, further studies should be considered to better investigate this relationship.

Systematic Method for Constructing Lewis Representations

The systematic method for constructing Lewis representations is a method for representing chemical bonds between atoms in a molecule. It uses symbols to represent the valence electrons of the atoms involved in the bond. Using a number of rules in a defined order, it is often better suited to complicated cases than the Lewis representation of atoms. This method allows us to determine the formal charge and oxidation number of each atom in the edifice more efficiently than other methods.

Management of Severely Malnourished Children Aged 6 - 59 Months Hospitalized in the Pediatric Ward of Kayanza Hospital/Burundi

The implementation of WHO guidelines has significantly reduced hospital mortality due to severe malnutrition. Nevertheless, severe acute malnutrition in children under five remains a major public health problem in all low-income countries and is little studied. The study aimed to assess the nutritional status and quality of management of severe acute malnutrition in children aged 06 to 59 months hospitalized in the pediatric ward of Kayanza Hospital. This is a prospective study with descriptive and analytical aims over 6 months from February 10 to July 9, 2023. All children aged 6 to 59 months admitted for severe acute malnutrition are included in this study. The results show that the most affected age group is 12 to 23 months (42.55%). Marasmus is the most common clinical form, at 70.2%. Housewives and mothers from rural areas are the most affected, with rates ranging from 69.14% to 91.49%. The study shows that the reasons for consultation are respectively: edema (29.78%), diarrhea (26.59%), vomiting (19.14%), and fever (14.89%). Dehydration and hypothermia were the main complications observed in 45.74% and 22.34% respectively. Medical treatment was provided by antibiotics (44.68%), artesunate (31.91%), and resomal (21.27%). Nutritional treatment consisted of F75 100% milk and F100 100% milk. Pathologies observed were: anemia 38.29%, malaria 37.23%, urinary tract infection 12.7%, measles 11.7%. The national protocol for integrated management of acute malnutrition (PCIMA) was followed. This study shows that 72.3% of children were successfully treated, with 9.5% dropping out and dying, and 8.5% not responding. We found that malnutrition remains a public health problem, affecting mostly children aged 12 to 24 months. The main complications or pathologies associated with malnutrition are diarrhea, malaria, and fever, and the majority of children suffer from marasmus.

Graphite Carbone Structure

Carbon graphite is a crystalline form of carbon consisting of layers of hexagonal carbon atoms arranged in a two-dimensional “graphene” structure. Graphene layers are stacked on top of each other, forming a three-dimensional structure with a high degree of anisotropy. The carbon atoms within each layer are linked together by strong covalent bonds, creating a strong, stable lattice structure. However, the layers themselves are held together by weak van der Waals forces, enabling them to slide easily over each other. The properties of carbon graphite are highly dependent on the orientation and alignment of the graphene layers. When the layers are aligned parallel to each other, the material exhibits high strength and stiffness along the alignment direction, but is weaker and more flexible in other directions. Carbon graphite is used in a variety of applications where high strength, rigidity and electrical conductivity are required. Some common applications include electrical contacts, electric motor brushes, and as a structural material in aerospace and defense applications. The aim of our work is to describe the structure of graphite, its physical and chemical properties and its applications.

Acute Generalized Peritonitis in Intensive Care Unit at University Hospital of Brazzaville, Republic of Congo: Etiological, Therapeutic Aspects and Issues

Aim: To determine etiological, therapeutic aspects and issues of AGP in intensive care unit (ICU) at University Hospital of Brazzaville (UHB). Materials and Methods: It was a retrospective and descriptive study carried out from January to December 2016 in ICU at UHB. We collected completed medical records of patients admitted and operated for AGP regardless of age or sex. The parameters studied were age, sex, admission’s reasons, etiologies, management, post-operative complications, length of hospital and mortality. Data were treated in Excel 2010 and Epi info 2007. Results: Thirty-one complete medical records were identified (mean age: 40.6 ± 22.0 years). The sex ratio was 2.4. Shock was the most common reason for admission with 67.7% of the cases. The etiologies of AGP were dominated by gastroduodenal perforating ulcer (41.9%) followed by complicated appendicitis (19.4%). The management of all patients was medico-surgical. The bi antibiotic ceftriaxone-metronidazole was administered in 29 patients (93.6%). 18 patients (59.1%) received vasopressor therapy. The complications had occurred among 9 patients i.e. 29% of the cases;parietal suppurations represented 44.5% of the complications. The average length of hospitalization was 5.2 ± 4.6 days. The overall mortality was 41.9%. Conclusion: In our study, the most frequent etiologies were gastroduodenal perforating ulcer and complicated appendicitis. They affected young patients. The complications were dominated by parietal suppurations. The mortality rate was high.

Improved Supervised and Unsupervised Metaheuristic-Based Approaches to Detect Intrusion in Various Datasets

Due to the increasing number of cyber-attacks,the necessity to develop efficient intrusion detection systems(IDS)is more imperative than ever.In IDS research,the most effectively used methodology is based on supervised Neural Networks(NN)and unsupervised clustering,but there are few works dedicated to their hybridization with metaheuristic algorithms.As intrusion detection data usually contains several features,it is essential to select the best ones appropriately.Linear Discriminant Analysis(LDA)and t-statistic are considered as efficient conventional techniques to select the best features,but they have been little exploited in IDS design.Thus,the research proposed in this paper can be summarized as follows.a)The proposed approach aims to use hybridized unsupervised and hybridized supervised detection processes of all the attack categories in the CICIDS2017 Dataset.Nevertheless,owing to the large size of the CICIDS2017 Dataset,only 25%of the data was used.b)As a feature selection method,the LDAperformancemeasure is chosen and combinedwith the t-statistic.c)For intrusion detection,unsupervised Fuzzy C-means(FCM)clustering and supervised Back-propagation NN are adopted.d)In addition and in order to enhance the suggested classifiers,FCM and NN are hybridized with the seven most known metaheuristic algorithms,including Genetic Algorithm(GA),Particle Swarm Optimization(PSO),Differential Evolution(DE),Cultural Algorithm(CA),Harmony Search(HS),Ant-Lion Optimizer(ALO)and Black Hole(BH)Algorithm.Performance metrics extracted from confusion matrices,such as accuracy,precision,sensitivity and F1-score are exploited.The experimental result for the proposed intrusion detection,based on training and test CICIDS2017 datasets,indicated that PSO,GA and ALO-based NNs can achieve promising results.PSO-NN produces a tested accuracy,global sensitivity and F1-score of 99.97%,99.95%and 99.96%,respectively,outperforming performance concluded in several related works.Furthermore,the best-proposed approaches are valued in the most recent intrusion detection datasets:CSE-CICIDS2018 and LUFlow2020.The evaluation fallouts consolidate the previous results and confirm their correctness.

New Denial of Service Attacks Detection Approach Using Hybridized Deep Neural Networks and Balanced Datasets

Denial of Service(DoS/DDoS)intrusions are damaging cyberattacks,and their identification is of great interest to the Intrusion Detection System(IDS).Existing IDS are mainly based on Machine Learning(ML)methods including Deep Neural Networks(DNN),but which are rarely hybridized with other techniques.The intrusion data used are generally imbalanced and contain multiple features.Thus,the proposed approach aims to use a DNN-based method to detect DoS/DDoS attacks using CICIDS2017,CSE-CICIDS2018 and CICDDoS 2019 datasets,according to the following key points.a)Three imbalanced CICIDS2017-2018-2019 datasets,including Benign and DoS/DDoS attack classes,are used.b)A new technique based on K-means is developed to obtain semi-balanced datasets.c)As a feature selectionmethod,LDA(Linear Discriminant Analysis)performance measure is chosen.d)Four metaheuristic algorithms,counting Artificial Immune System(AIS),Firefly Algorithm(FA),Invasive Weeds Optimization(IWO)and Cuckoo Search(CS)are used,for the first time together,to increase the performance of the suggested DNN-based DoS attacks detection.The experimental results,based on semi-balanced training and test datasets,indicated that AIS,FA,IWO and CS-based DNNs can achieve promising results,even when cross-validated.AIS-DNN yields a tested accuracy of 99.97%,99.98%and 99.99%,for the three considered datasets,respectively,outperforming performance established in several related works.

Reply: Comment on “Geological mapping and mining prospecting in the Aouli inlier (Eastern Meseta, Morocco) based on remote sensing and geographic information systems (GIS)” by Benaissi et al. (China Geology, 5 (2022))

We have been pleased that our paper Geological mapping and mining prospecting in the Aouli inlier(Eastern Meseta,Morocco) based on remote sensing and geographic information systems(GIS) was of interest to our colleagues who commented it in China Geology 5(2022) 1–4.

Assessment of forest dieback on the Moroccan Central Plateau using spectral vegetation indices

Cork oak forests in Morocco are rich in resources and services thanks to their great biological diversity,playing an important ecological and socioeconomic role.Considerable degradation of the forests has been accentuated in recent years by signifi cant human pressure and eff ects of climate change;hence,the health of the stands needs to be monitored.In this study,the Google Engine Earth platform was leveraged to extract the normalized diff erence vegetation index(NDVI)and soil-adjusted vegetation index,from Landsat 8 OLI/TIRS satellite images between 2015 and 2017 to assess the health of the Sibara Forest in Morocco.Our results highlight the importance of interannual variations in NDVI in forest monitoring;the variations had a signifi cantly high relationship(p<0.001)with dieback severity.NDVI was positively and negatively correlated with mean annual precipitation and mean annual temperature with respective coeffi cients of 0.49 and−0.67,highlighting its ability to predict phenotypic changes in forest species.Monthly interannual variation in NDVI between 2016 and 2017 seemed to confi rm fi eld observations of cork oak dieback in 2018,with the largest decreases in NDVI(up to−38%)in December in the most-aff ected plots.Analysis of the infl uence of ecological factors on dieback highlighted the role of substrate as a driver of dieback,with the most severely aff ected plots characterized by granite-granodiorite substrates.

Epidemic to Different Strains of SERRATIA: Experience of Neonatal Intensive Care Unit: About 30 Cases

Serratia is an opportunistic pathogenic bacterium of the Enterobacteriaceae family, occasionally responsible for epidemics of nosocomial infections in critical departments;in particular in neonatal intensive care units Enterobacteriaceae form a large family of Gram-negative bacteria, which cause diseases of highly variable severity, due to distinct pathogenic mechanisms. This family is heterogeneous as it consists of about 30 genera of bacteria and more than 100 species. However, all these germs have in common their preferential location in the digestive system, some being part of the normal flora although they are also present in the environment. Several metabolic processes characterize this bacterial family. These include the ability to reduce nitrate to nitrite (for energy generation), ferment glucose, lack cytochrome oxidase, be aerobic or anaerobic, motile or immobile, … Enterobacteriaceae constitute more than 80% of the germs isolated in the laboratory: Escherichia, Salmonella, Shigella, Klebsiella, Enterobacter, Serratia, Proteus, Morganella and Yersinia are the rods most often found. Regarding nosocomial infection to Serratia, this bacterium colonizes the respiratory, digestive and urinary systems of patients, mainly responsible for bacteremia, infections of the lower respiratory tract, urinary and skin infections. Through our work, we report the epidemic experienced in the neonatal intensive care unit MOHAMMED VI university hospital, mother-child hospital MARRAKECH MOROCCO for three months from December at February 2023 interesting 30 newborns whose clinical presentation was different, the positive diagnosis was based on blood and geographical samples taken by the bacteriology department to isolate the offending germs, the therapeutic management of our patients consisted essentially of various hygiene measures in association with dual antibiotic therapy based on meropenem and amikacin. The evolution was marked by the death of 21 patients (70%) and the recovery of 9 patients (30%). The prognosis of infection by serratia remains bleak with high morbidity interest in prevention by respecting the rules of hygiene, which begins with hand disinfection.

Neonatal Pleuropulmonary Staphylococcal Disease: A Case Report

Staphylococcal pleuropulmonary disease (SPP) is the localization of pathogenic staphylococcal disease in the lung and pleura and its general haematogenic consequences. This location is not primary, but follows a primary skin or mucous infection that may go unnoticed. This is a very rare phenomenon in neonatology and in the various literature reviews. Through our observation we report the clinical diagnosis of a newborn 13-day age with pleuro-pulmonary staphyloccocia point of departure cutaneous, thus the paraclinical explorations performed in our patient therapeutic management and evolutionary profile after a 3-month decline. Note that the problem of resistance of staphylococci to different antibiotics is currently a real public health problem making the choice of treatment very difficult for the clinician.

Pantoea SPP: A New Nosocomial Infection in the Neonatal Intensive Care Unit

Pantoea SPP is a gram-negative bacillus, which usually colonizes plants, soil and water. This pathogen very rarely causes neonatal sepsis. The most common infections caused by Pantoea SPP are septic arthritis or synovitis, meningitis frequently complicated by brain abscess, upper respiratory infections, and peritonitis. We present the case of a premature infant who presented neonatal respiratory distress and whose evolution was complicated by the occurrence of a nosocomial infection for which a blood culture was performed isolating the germ Pantoea SPP. The patient’s management was initially centered on non-invasive ventilation with antibiotherapy based on carbapenem and aminoglycoside. Due to the clinical and biological worsening, the neonate was intubated and sedated and put on colymicin. The evolution was unfavorable marked by a death at 16th days of life. Considering the high pathogenicity of this germ and its multi-resistance to antibiotics, it is crucial to know the clinical spectrum of Panteoa SPP infections in neonatal intensive care units, in order to palliate the fulminant evolution of multifocal attacks due to this germ.

Nosocomial Klebsiella variicola Infection in Neonatal Intensive Care: A New Emerging Pathogen

Klebsiella variicola is a human pathogen that has been misidentified as K. pneumoniae. This misidentification has led to a lack of understanding of important clinical and biological aspects of this bacterial species. It is responsible for serious and potentially fatal infections, with a prevalence of multi-resistance to routine antibiotics. We present through three clinical observations, the case of three newborns having been hospitalized in the neonatal intensive care unit and whose evolution was complicated by the occurrence of a nosocomial infection in front of which a blood culture was done on blood agar, with a manual antibiogram on antibiotic disks, isolated the germ Klebsiella variicola. The management of the newborns was initially centered on non-invasive ventilation with a bi-antibiotic therapy based on carbapenem and amikacin for two newborns and switched to colymicin for the third case. Newborn follow-up was based on assessment of general condition, clinical signs of infection, as well as a biological control made of a blood count, a c-reactive protein, a complete ionogram, and a blood culture, every four days or if signs of clinical call. The evolution was favorable for two cases with good clinical and biological improvement, and complicated by death due to alveolar hemorrhage in the third case. Given the high pathogenicity of this germ, and the frequency of misidentification, it is crucial to know the clinical spectrum of Klebsiella variicola infections in neonatal intensive care units, in order to adapt the antibiotic therapy and to mitigate the fulminant evolution of this germ.

Rectal Endometriosis Revealed by a Colonic Tumor Obstruction: A Case Report

Endometriosis is defined as the presence of endometrial tissue that is located outside the uterine cavity, associated with fibrosis and inflammatory reaction. The most common atypical locations are the gastrointestinal tract, urinary tract, lung, as well as abdominal surgical scars. Its diagnosis is still very difficult, especially when it manifests itself as an acute large bowel obstruction. We report the rare case of a 41-year-old patient diagnosed with acute colonic obstruction following a rectal tumor. She had undergone colonostomy even though colonoscopy biopsies were nonspecific, and a computed tomography (CT) scan was requested. It showed an adnexal heterogenous mass, therefore the patient had a laparotomy and a subtotal hysterectomy with bilateral salpingo-oophorectomy and a biopsy of the recto-colonic hinge. Histologic examination revealed a diagnosis of rectal endometriosis. The purpose of this work is to report a rare case of colonic endometriosis responsible for an acute large bowel obstruction.

Impact of Heat Treatments and Hole Density (p) on the Structural, Electrical, and Superconducting Properties of LnSrBaCu3O6+z (Ln = Eu, Sm, Nd) Compounds

In this study, we thoroughly examined the impact of heat treatments and hole count (p) on the properties of LnSrBaCu3O6+z (Ln = Eu, Sm, Nd) compounds. We focused on preparation, X-ray diffraction with Rietveld refinement, AC susceptibility, DC resistivity measurements, and heat treatment effects. Two heat treatment types were applied: oxygen annealing [O] and argon annealing followed by oxygen annealing [AO]. As the rare earth Ln’s ionic radius increased, certain parameters notably changed. Specifically, c parameter, surface area S, and volume V increased, while critical temperature Tc and holes (p) in the CuO2 plane decreased. The evolution of these parameters with rare earth Ln’s ionic radius in [AO] heat treatment is linear. Regardless of the treatment, the structure is orthorhombic for Ln = Eu, tetragonal for Ln = Nd, orthorhombic for Ln = Sm [AO], and pseudo-tetragonal for Sm [O]. The highest critical temperature is reached with Ln = Eu (Tc [AO] = 87.1 K). Notably, for each sample, Tc [AO] surpasses Tc [O]. Observed data stems from factors including rare earth ionic size, improved cationic and oxygen chain order, holes count p in Cu(2)O2 planes, and in-phase purity of [AO] samples. Our research strives to clearly demonstrate that the density of holes (p) within the copper plane stands as a determinant impacting the structural, electrical, and superconducting properties of these samples. Meanwhile, the other aforementioned parameters contribute to shaping this density (p).

Processes for the Clarification of the Crude Oil of Baobab Seeds Extracted by Pressing on Activated Carbon Elaborated from the Capsules of the Fruit (Adansonia digitata L.)

The baobab, Adansonia digitata L. plays an important role in the economy of local populations. The oil from the seeds of the baobab fruit is nowadays highly prized because of its numerous cosmetic and therapeutic applications and its composition of unsaturated fatty acids, sterols and tocopherols. However, unlike refined oils, locally extracted baobab oil has not undergone purification operations to ensure its quality. Only a filtration on special cloths is carried out after decantation. Indeed, the oil obtained after pressing is cloudy because of the presence of various impurities. It therefore requires treatment operations to make it more attractive and of higher quality. Therefore, in order to provide innovative solutions to local companies to improve the quality of vegetable oils, a study of clarification (treatment) of crude oil is necessary. An experimental device has been developed in the laboratory. It includes a glass column and a filter bed of dune sand and activated carbon. This study has shown the efficiency of the experimental device. Indeed, the activated carbon, thanks to its adsorbing power, has allowed a significant decrease in turbidity at the 5% threshold, from 14.61 NTU for the raw oil to 0.08 NTU for the oil filtered on 3% carbon and 0.033 NTU for the oil filtered on 5% carbon. That is to say an abatement higher than 95%. This decrease in turbidity could be correlated with the decrease in brown index from 187.39a for the initial crude oil to 128.53d for the oil treated with 3% activated carbon versus 187.59a for the oil filtered on cloths. The lowest brown index was observed with the filtration using 5% activated carbon (35.99b). Thus, for the yellowness index, only the filtration on 5% charcoal allowed to obtain a significant decrease in yellowness. The yellowing index of the oil with 5% was 44.67b against 79.04a for the oil filtered with 3% activated carbon, 86.33a for the crude oil and 86.46a for the oil filtered on cloths. Finally, the oil sample treated with 5% activated carbon had the clearest clarity than the other samples with a clarity (L) equal to 97.98c against 95.63d for the oil treated with 3% carbon and 94.99b for the oil filtered on filter cloths. According to the results obtained, the experimental device made it possible to obtain a clearer baobab oil with a low brown index, thus improving the sensory quality of the oil.

Assessment of Nutritional Status and Associated Factors in Infants Aged 6 to 23 Months in Rural Burundi

This study was carried out in the Health districts of Kayanza and Gahombo. Its aim was to assess the nutritional status and associated factors of infants aged between 6 and 23 months. This descriptive and cross-sectional study was carried out in the health centers of the action zone during medical consultations in community medicine from 13 to 22 February 2023. For this purpose, 53.0% of a sample of 398 mothers of infants aged 6 - 23 months were male, and the most represented age group was 12 - 23 months with 53.8%. Mothers were asked about the diet of their children. All the children involved in this study were vaccinated, whereas 99.2% were given vitamin A supplements. The most frequent illnesses in this age group were acute respiratory infection (ARI) (73.4%), fever (66.6%), diarrhea (53.8%), and vomiting (40.5%). Analysis of nutritional status showed that infants had severe (8.3%) and moderate (70.4%) acute malnutrition. Factors associated with infant nutritional status comprised the occupation of mother (P = 0.009), level of education of mother (P = 0.0625), and prolonged diarrhea (P = 0.004). To remedy this problem, concrete nutritional and educational interventions are needed to promote optimal infant nutrition during the first two years of life.

Endophytic actinobacteria of medicinal plant Aloe vera: Isolation, antimicrobial, antioxidant, cytotoxicity assays and taxonomic study

Objective: To explore the new sources of novel bioactive compounds having pharmaceutical and agricultural interest and to search the endophytic actinobacteria from medicinal plants. Methods: NAF-1 an endophyte actinobacteria was isolated from leaves of medicinal plant Aloe vera collected in Marrakesh, Morocco using Bennett agar as selective medium. NAF-1 was tested for its antimicrobial activity against five pathogenic bacteria such as Staphylococcus aureus PIC 53156, Micrococcus luteus ATCC381, Bacillus subtilis ATCC 14579, Pseudomonas aeruginosa DSM 50090 and Escherichia coli ATCC 8739 and four human clinic fungi belonging to the Candida, Aspergillus and Microsporum genera. Several antioxidant activities were studied such as DPPH free radical scavenging, β-carotene and linoleic acid and reducing power assays. The total of phenol and flavonoid was also calculated. Using Artemia salina shrimp assay, the cytotoxicity of NAF-1 crude extract was determined. Results: The results revealed that the actinobacteria showed a high activity(≥20 mm) against only Gram positive bacteria but it had a moderate activity(between 13 and 15 mm) against Human clinic fungi. The isolate also exhibited a LD50 of 14.20 μg/mL in the cytotoxicity assay. The result showed that the crude extract presented an interesting free radical-scavenging activity with IC50 value of(5.58 ± 0.26) μg/mL and a high value of phenolic and flavonoid compounds with(15.41 ± 0.18) μg GAE/mg extract and(11.41± 0.06) μg QE/mg extract respectively. Moreover, the taxonomic position of our endophyte actinobacteria using the morphological and physiological criteria and using 16 S r RNA gene sequence(polyphasic approach) showed that the NAF-1 isolate was similar to Streptomyces hydrogenans which was never described as an endophyte actinobacteria. Conclusions: This isolated strain appears promising resources of bioactive agents and can be exploited to produce therapeutic agents active against pathogenic disease.

Geological mapping and mining prospecting in the Aouli inlier(Eastern Meseta,Morocco)based on remote sensing and geographic information systems(GIS)

Landsat 8 Oli,ASTER,and Sentinel 2A satellite images processing was used to map geological formations,lineaments and hydrothermal alteration minerals in the Aouli inlier,as a case study to illustrate the application of digital images processing and Geographic Information System(GIS)in geological mapping and mining prospecting.Principal Component Analysis(PCA)applied to the Landsat images allowed good lithological discrimination and contributed to the updating of available geological maps.The Automatic lineament extraction from Sentinel images revealed the main tectonic structures affecting Aouli inlier.The ratio bands(b5+b7)/b6 and the false color composite(b4/b6,b2/b1,b3/b2)allowed the hydrothermal alteration minerals mapping from Aster images.Combined with available geological data and field observations,the satellite derived data were integrated and analyzed in a GIS software to establish mining prospecting guides.The results showed that the anomaly zones are intimately linked to NNE-SSW and NW-SE oriented faults and to highly fractured areas developing argillic and Fe rich alterations.Verified via field survey,this approach was successfully applied to the Aouli inlier to rapidly target potential areas to be explored in the tactical phase.This provides a model for future prospecting efforts for similar mineral deposits in other areas.