The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as glutathione to address offensive enhanced cytokines, in patients with suspected PANDAS/CANS.

The Global Boundary Stratotype Section and Point （GSSP） for the base of the Hirnantian Stage （the uppermost of the Ordovician System）

The Global boundary Stratotype Section and Point （GSSP） for the base of the Hirnantian Stage （the uppermost of the Ordovician System） is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangjiawan North section. The section is located near Wangjiawan village, 42 km north of Yichang city （western Hubei, China）, at 30° 58′56″N and 111° 25′10″E. The GSSP level coincides with the first appearance of the graptolite species Normalograptus extraordinarius （Sobolevskaya）. Secondary markers include the onset of a positive carbon-isotope excursion, and a slightly earlier first appearance of Normalograptus ojsuensis （ Koren and Mikhailova ）. The Wangjiawan North section possesses continuity of sedimentation and biozonation with completeness of exposures, abundant and well-preserved graptolites and shelly fossils, i. e. the Hirnantia- Dalmanitina shelly fauna which is a key element for recognition of the Hirnantian Stage. The Wangjiawan North, South and Riverside sections possess favorable facies and widespread correlation potential, are free from structure complication, metamorphism and other alteration, and have good accessibility. The Riverside section in particular possesses amenability to isotopic age determination. The beginning of the Hirnantian was followed by a global episode of a major extinction event, which happened in the Diceratograptus mirus Subzone. The proposal was voted by the International Subcommission on Ordovician Stratigraphy in October, 2004, approved by the International Commission on Stratigraphy in February, 2006, and ratified by the International Union of Geological Sciences in May, 2006.

Some Explicit Results for the Distribution Problem of Stochastic Linear Programming

A technique is developed for finding a closed form expression for the cumulative distribution function of the maximum value of the objective function in a stochastic linear programming problem, where either the objective function coefficients or the right hand side coefficients are continuous random vectors with known probability distributions. This is the “wait and see” problem of stochastic linear programming. Explicit results for the distribution problem are extremely difficult to obtain;indeed, previous results are known only if the right hand side coefficients have an exponential distribution [1]. To date, no explicit results have been obtained for stochastic c, and no new results of any form have appeared since the 1970’s. In this paper, we obtain the first results for stochastic c, and new explicit results if b an c are stochastic vectors with an exponential, gamma, uniform, or triangle distribution. A transformation is utilized that greatly reduces computational time.

Optimization of top polymer gratings to improve GaN LEDs light transmission

We present a grating model of two-dimensional （2D） rigorous coupled wave analysis （RCWA） to study top diffraction gratings on light-emitting diodes （LEDs）. We compare the integrated-transmission of the non-grating, rectangular-grating, and triangular-grating cases for the same grating period of 6 μm, and show that the triangular grating has the best performance. For the triangular grating with 6-μm period, the LED achieves the highest light transmission at 6-μm grating bottom width and 2.9-μm grating depth. Compared with the non-grating case, the optimized light transmission improvement is about 74.6%. The simulation agrees with the experimental data of the thin polymer grating encapsulated flip-chip （FC） GaN-based LEDs for the light extraction improvement.