Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury.Du et al.,reporting in Cell Stem Cell,employ a FUCCI-and MADM-based system to screen for small molecules combinatio...Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury.Du et al.,reporting in Cell Stem Cell,employ a FUCCI-and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis.The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency,and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry.展开更多
基金This work is supported by NIH(R01HL138456 and R01HL157280),American Heart Association Transformation AwardTobacco-Related Disease Research Program.
文摘Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury.Du et al.,reporting in Cell Stem Cell,employ a FUCCI-and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis.The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency,and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry.
