For the quantitative determination of Fulvestrant, Benzyl alcohol, and Benzyl benzoate in Fulvestrant injection, an original RP-HPLC approach was developed. The gradient method was developed using HPLC and a Phenomene...For the quantitative determination of Fulvestrant, Benzyl alcohol, and Benzyl benzoate in Fulvestrant injection, an original RP-HPLC approach was developed. The gradient method was developed using HPLC and a Phenomenex Luna C8, 150 × 4.6 mm, i.d 3.0 μm particle size column with a gradient programme of mobile phases A and B. With a flow rate of 1.5 mL/minute, injection volume of 10 μL, and column temperature of 35°C, UV wavelength detection at 254 nm for Benzyl alcohol and Benzoyl Benzoate and 280 nm for Fulvestrant, mobile phase-A consists of DI water and mobile phase-B consists of Acetonitrile. The current study describes a single HPLC method for developing a Fulvestrant (Active), Benzyl alcohol (Cosolvent), and Benzyl Benzoate (Cosolvent) assay for Fulvestrant injection. The assay method was determined to be suitable for quantifying three components in the pharmaceutical product and was verified according to ICH guidelines.展开更多
We are examining the behavior of a composite made of ferroelectrics with strong dielectric properties and ferrites with magnetic properties due to the rising need for materials for multipurpose devices.Many applicatio...We are examining the behavior of a composite made of ferroelectrics with strong dielectric properties and ferrites with magnetic properties due to the rising need for materials for multipurpose devices.Many application avenues will be favored by the pairing of these materials’individual qualities with one another.Perovskite and U-type hexaferrite composite materials have been chosen for this study based on their magnetic and dielectric properties.The composites,(1−x)PLT−x(Ba1−3xNd2x)4Co2Fe36O60 where x=0.52,0.54,0.56,0.58 are prepared by solid state reaction method and phase formation was examined.Consideration has been given to the magnetic,dielectric,and magneto-dielectric properties.This work has established the link between the electric and magnetic domains while applying electric and magnetic forces to the materials.The magneto-dielectric research revealed magneto-electric coupling in all of the samples.However,the sample shows the maximum coupling for x=0.54 with MDR%values of 93.17%,which might be because this sample appears to have a high magneto-resistance(161%).展开更多
文摘For the quantitative determination of Fulvestrant, Benzyl alcohol, and Benzyl benzoate in Fulvestrant injection, an original RP-HPLC approach was developed. The gradient method was developed using HPLC and a Phenomenex Luna C8, 150 × 4.6 mm, i.d 3.0 μm particle size column with a gradient programme of mobile phases A and B. With a flow rate of 1.5 mL/minute, injection volume of 10 μL, and column temperature of 35°C, UV wavelength detection at 254 nm for Benzyl alcohol and Benzoyl Benzoate and 280 nm for Fulvestrant, mobile phase-A consists of DI water and mobile phase-B consists of Acetonitrile. The current study describes a single HPLC method for developing a Fulvestrant (Active), Benzyl alcohol (Cosolvent), and Benzyl Benzoate (Cosolvent) assay for Fulvestrant injection. The assay method was determined to be suitable for quantifying three components in the pharmaceutical product and was verified according to ICH guidelines.
文摘We are examining the behavior of a composite made of ferroelectrics with strong dielectric properties and ferrites with magnetic properties due to the rising need for materials for multipurpose devices.Many application avenues will be favored by the pairing of these materials’individual qualities with one another.Perovskite and U-type hexaferrite composite materials have been chosen for this study based on their magnetic and dielectric properties.The composites,(1−x)PLT−x(Ba1−3xNd2x)4Co2Fe36O60 where x=0.52,0.54,0.56,0.58 are prepared by solid state reaction method and phase formation was examined.Consideration has been given to the magnetic,dielectric,and magneto-dielectric properties.This work has established the link between the electric and magnetic domains while applying electric and magnetic forces to the materials.The magneto-dielectric research revealed magneto-electric coupling in all of the samples.However,the sample shows the maximum coupling for x=0.54 with MDR%values of 93.17%,which might be because this sample appears to have a high magneto-resistance(161%).
