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Multidisciplinary management of ulcerative colitis complicated by immune checkpoint inhibitor-associated colitis with life-threatening gastrointestinal hemorrhage:A case report
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作者 Na Hong Bo Wang +4 位作者 Hang-Cheng Zhou Zheng-Xiang Wu Hua-Ying Fang Geng-Qing Song Yue Yu 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第7期2329-2336,共8页
BACKGROUND Programmed cell death 1(PD-1)inhibitors are immune checkpoint inhibitors(ICI)that have demonstrated significant efficacy in treating various advanced malignant tumors.While most patients tolerate treatment ... BACKGROUND Programmed cell death 1(PD-1)inhibitors are immune checkpoint inhibitors(ICI)that have demonstrated significant efficacy in treating various advanced malignant tumors.While most patients tolerate treatment well,several adverse drug reactions,such as fatigue,myelosuppression,and ICI-associated colitis,have been reported.CASE SUMMARY This case involved a 57-year-old male patient with ulcerative colitis complicated by hepatocarcinoma who underwent treatment with tirelizumab(a PD-1 inhibitor)for six months.The treatment led to repeated life-threatening lower gastrointestinal hemorrhage.The patient received infliximab,vedolizumab,and other salvage procedures but ultimately required subtotal colectomy due to uncontrollable massive lower gastrointestinal bleeding.Currently,postoperative gastrointestinal bleeding has stopped,the patient’s stool has turned yellow,and his full blood cell count has returned to normal.CONCLUSION This case highlights the necessity of early identification,timely and adequate treatment of ICI-related colitis,and rapid escalation to achieve the goal of improving prognosis. 展开更多
关键词 Ulcerative colitis Hepatocarcinoma Immune checkpoint inhibitor-associated colitis Colectomy Case report
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The Roadmap for Lenovo to Go Global——A Case study of Lenovo Group Strategies
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作者 Cheung Kong GSB Case Study Centre 《China Economist》 2007年第6期132-140,共9页
I.Lenovo: refocus on PC operation On December 8th, 2004, Lenovo consummated a deal with IBM whereby Lenovo was to acquire IBM’s desktop and laptop PC unit and its R&D and procurement operations worldwide for the... I.Lenovo: refocus on PC operation On December 8th, 2004, Lenovo consummated a deal with IBM whereby Lenovo was to acquire IBM’s desktop and laptop PC unit and its R&D and procurement operations worldwide for the sum of US$1.25 billion. On May 1st 2005, Lenovo completed its acquisition of IBM’s PC Unit. "Using an analogy, our enterprise is well likened to a tortoise but our foreign competitor is more like a rabbit. Instead of racing against the rabbit heads-on, we would rather ride on its back and let it carry us forward," said former Lenovo Chairman Liu Chuanzhi. 展开更多
关键词 CASE In The Roadmap for Lenovo to Go Global A Case study of Lenovo Group Strategies IBM IT
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Isolated colonic neurofibroma, a rare tumor: A case report and review of literature
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作者 Sara Ghoneim Sonia Sandhu Dalbir Sandhu 《World Journal of Clinical Cases》 SCIE 2020年第10期1932-1938,共7页
BACKGROUND Neurofibromas are tumors comprised of peripheral nerve sheath and connective tissue components.They can occur sporadically or as part of familial syndromes such as neurofibromatosis type 1.Isolated colonic ... BACKGROUND Neurofibromas are tumors comprised of peripheral nerve sheath and connective tissue components.They can occur sporadically or as part of familial syndromes such as neurofibromatosis type 1.Isolated colonic neurofibroma without systemic manifestations is a rarely reported clinical entity.Here we present a case of a 51 years old male with an isolated colonic neurofibroma seen on a screening colonoscopy.CASE SUMMARY Fifty-one years old male who was otherwise healthy without a significant family history of cancer underwent a screening colonoscopy and was found have a 2.3 cm×1.4 cm lesion in the colon.Tissue biopsy revealed a spindle cell tumor.Magnetic resonance imaging of the pelvis was negative for adenopathy.He underwent an endoscopic ultrasound that showed an ill-defined avascular lesion of mixed echogenicity measuring 2.8 cm×15.2 cm in the submucosa with no communication with muscularis mucosa or propria.Immunohistochemistry staining of the tumor was strongly positive for S100,with rare penetrating axons deep within the tumor.Tumor cells were negative for c-kit and desmin and had low Ki-67 index.These findings were consistent with a solitary colonic submucosal neurofibroma.A detailed history and physical examination did not reveal any evidence of extraintestinal neurofibromatosis.He underwent transanal surgical resection of the tumor.The patient tolerated the procedure well without any complications.CONCLUSION While neurofibromas have been well described in literature,an isolated colonic neurofibroma is a rare pathological entity.Malignant transformation of neurofibromas has been reported in patients with neurofibromatosis syndromes.We report a case of isolated colonic neurofibroma and highlight the importance of resection due to the increased risk of tumorigenesis. 展开更多
关键词 NEUROFIBROMA COLONOSCOPY Neurofibromatosis type 1 Neurofibromatosis type 2 Spindle cell tumor Endoscopic ultrasound Case report
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Generation of Ultrasound Based on the Frequency Response Characteristics of the “Koss Pro Headphone” with R. David Case Sound Wave Files’—A Case Study
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作者 R. David Case D. Chuckravanen 《World Journal of Engineering and Technology》 2021年第2期374-383,共10页
The research aim of this work is to analyse the characteristics of R. David Case Sound waves that are posited to have positive effects on people suffering from tinnitus. Moreover, the participants who listened to thes... The research aim of this work is to analyse the characteristics of R. David Case Sound waves that are posited to have positive effects on people suffering from tinnitus. Moreover, the participants who listened to these sound wave files using specific headsets or headphones of the Koss models (ktx Pro, ksc-75) showed improved health condition such as alleviating tinnitus that they are suffering from. Therefore, these discoveries have encouraged R. David Case to pursue positively his journey into finding out what is special about those sounds when being listened specifically with Koss models. In this research, we focus mainly on the technical aspects of R. David Case sound signals which he has recorded. These specific sound waves were analysed using time domain, frequency domain as well as the effect of using the Koss Pro headphone frequency response characteristics applied to the sound. Results obtained from the analysis demonstrated that the generation of ultrasound c</span><span style="font-family:Verdana;">an</span><span style="font-family:Verdana;"> be the underlying reason for the treatment of the tin</span><span style="font-family:Verdana;">n</span><span style="font-family:Verdana;">itus. 展开更多
关键词 ULTRASOUND TINNITUS David Case Sound Wave File Frequency Analysis Healing
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Pediatric-type follicular lymphoma in a Crohn’s disease patient receiving anti-α4β7-integrin therapy:A case report
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作者 Keval Yerigeri Ilia Buhtoiarov 《World Journal of Gastroenterology》 SCIE CAS 2023年第43期5865-5871,共7页
BACKGROUND Patients with autoimmune conditions receiving immunosuppressants are at risk of non-Hodgkin lymphomas(NHL).Vedolizumab(anti-α4β7-integrin antibody),a treatment-of-choice for Crohn’s disease(CD),reduces i... BACKGROUND Patients with autoimmune conditions receiving immunosuppressants are at risk of non-Hodgkin lymphomas(NHL).Vedolizumab(anti-α4β7-integrin antibody),a treatment-of-choice for Crohn’s disease(CD),reduces inflammatory lymphocyte trafficking into the intestinal mucosa.This effect is believed to be confined to the colon.CASE SUMMARY We report the case of a CD patient on vedolizumab for five years who developed pediatric-type follicular lymphoma.Work-up prior to therapy revealed a reduction in circulating T-lymphocytes and their suppressed response to mitogens.Rituximab,cyclophosphamide,vincristine,and prednisone chemoimmunotherapy resulted in durable lymphoma remission,and vedolizumab treatment was continued.While the patient’s T-lymphocyte population and immunoglobulin production recovered,the T-lymphocyte mitogen response remained suppressed.CONCLUSION This patient’s NHL may be linked to receiving anti-α4β7 therapy.Further research could be beneficial to determine if proactive surveillance for NHL and other systemic diseases is indicated in patients on vedolizumab. 展开更多
关键词 Pediatric-type follicular lymphoma Crohn’s disease Vedolizumab IMMUNOSUPPRESSION Non-Hodgkin lymphoma Case report
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DIAGNOSIS OF To CARCINOMA OF THE BREAST (A REPORT OF 74 CASES)
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作者 李树玲 李云英 +1 位作者 石松魁 方志沂 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1989年第1期58-63,共6页
From 1978 through 1986, 74 cases (77 lesions) of T0 carcinoma of the breast were studied. All of these cases were treated with mastectomy. Pathologically, 52 cases (67.5%) were early carcinoma, including non-invasive ... From 1978 through 1986, 74 cases (77 lesions) of T0 carcinoma of the breast were studied. All of these cases were treated with mastectomy. Pathologically, 52 cases (67.5%) were early carcinoma, including non-invasive (30), early invasive (19) and specific type (3). Axillary lymph node metastasis was present in 12.9% of the cases. Follow-up study revealed that 46 patients have been living and in good health for 3-5 years. For successful detection, the following prerequisites are indispensable: (1) physicians concerned must be aware of the new concept that most early breast carcinoma may not be palpable; (2) physicians must be well familiarized with the clinical manifestations of nonpalpable carcinoma of the breast; (3) any abnormalities of the breast must be thoroughly investigated until proven otherwise; and <4) combined diagnostic procedures must be used. 展开更多
关键词 DIAGNOSIS OF To CARCINOMA OF THE BREAST A REPORT OF 74 CASES
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INTRALUMINAL ELASTIC CIRCULAR LIGATION FOR ESOPHAGOGASTRIC ANASTOMOSIS(INCLUDING THE CLINICAL ANALYSES OF 100 CASES)
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作者 张毓德 杜喜群 +1 位作者 王其彰 张增强 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1989年第2期51-55,共5页
Between 1981 and 1988, 234 cases of cancerof the esophagus or gastric cardia were treatedby resection and intraluminal elastic circularligation for esophagogastric anastomosis. Thispresent study advances the results d... Between 1981 and 1988, 234 cases of cancerof the esophagus or gastric cardia were treatedby resection and intraluminal elastic circularligation for esophagogastric anastomosis. Thispresent study advances the results described inour earlier study. The details of technicalrefinements are here reported, based on the 展开更多
关键词 INTRALUMINAL ELASTIC CIRCULAR LIGATION FOR ESOPHAGOGASTRIC ANASTOMOSIS INCLUDING THE CLINICAL ANALYSES OF 100 CASES
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PRIMARY PLASMA CELL LEUKEMIA(A COMPREHENSIVE ANALYSIS OF 44 CASES)
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作者 蔡则骥 张国祯 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1991年第2期74-77,共4页
Four cases of primary plasma cell leukemia (PPCL) admitted to Zhongshan Hospital from 1959 to 1987 are reported with a review on additional 40 cases reported in China. Comparing with the 57 cases of multiple myeloma (... Four cases of primary plasma cell leukemia (PPCL) admitted to Zhongshan Hospital from 1959 to 1987 are reported with a review on additional 40 cases reported in China. Comparing with the 57 cases of multiple myeloma (MM) treated in our hospital, the following features were observed in PPCL: (1) The age was younger, with a mean of 45.2 years, 34.1% of the patients were under 40 years. (2) Onset was abrupt. Duration from onset to diagnosis was 2 months or less in 77% patients but never beyond 6 months. (3) 81.8% patients had liver enlargement, 59.1% splenomegaly and 61.4% sternum tenderness. (4) All patients showed marked anemia with an average hemoglobin of 65 g/L. BPC count was less than 100 × 109/L in 76% patients and WBC was more than 10×109/L in 77%. (5) Plasma cell number in the marrow was markedly increased with an average of 69%, of which the blast cells and immature forms were predominant. (6) No destruction of bones was shown on X-ray film in 68.3% patients. (7) The response to chemotherapy was poor with a total response rate of 18% and a mean survival of 2 months. All the above-mentioned clinical features were significantly different from those of MM. In addition, these two diseases were also different in cytology, cytogenetics and ultrastructure. Therefore, PPCL should be considered as a special type of acute leukemia distinct from MM. High dose of alkylating agents in combination with autologous bone marrow transplantation might improve the prognoses. 展开更多
关键词 PPCL PRIMARY PLASMA CELL LEUKEMIA A COMPREHENSIVE ANALYSIS OF 44 CASES
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case of familial hyperlipoproteinemia type Ⅲ hypertriglyceridemia induced acute pancreatitis: role for outpatient apheresis maintenance therapy 被引量:10
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作者 Mohannad Abou Saleh Emad Mansoor Gregory S Cooper 《World Journal of Gastroenterology》 SCIE CAS 2017年第40期7332-7336,共5页
Hypertriglyceridemic pancreatitis(HTGP) accounts for up to 10% of acute pancreatitis presentations in nonpregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. Ther... Hypertriglyceridemic pancreatitis(HTGP) accounts for up to 10% of acute pancreatitis presentations in nonpregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis and insulin infusion in the acute inpatient setting. We report a case of HTGP in a male with hyperlipoproteinemia type Ⅲ who was treated successfully with insulin and apheresis on the initial inpatient presentation followed by bi-monthly outpatient maintenance apheresis sessions for the prevention of recurrent HTGP. We also reviewed the literature for the different inpatient and outpatient management modalities of HTGP. Given that there are no guidelines or randomized clinical trials that evaluate the outpatient management of HTGP, this case report may provide insight into a possible role for outpatient apheresis maintenance therapy. 展开更多
关键词 APHERESIS PANCREATITIS PLASMAPHERESIS OUTPATIENT HYPERTRIGLYCERIDEMIA
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Kangaroo Care (Skin-to-Skin) for Clustered Pain Procedures: Case Study 被引量:2
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作者 Raouth R. Kostandy Susan M. Ludington-Hoe 《World Journal of Neuroscience》 2016年第1期43-51,共9页
Background: Pain management for term newborns undergoing clustered painful procedures has not been tested. Kangaroo Care (chest-to-chest, skin-to-skin position of infant on mother) effectively reduces pain o... Background: Pain management for term newborns undergoing clustered painful procedures has not been tested. Kangaroo Care (chest-to-chest, skin-to-skin position of infant on mother) effectively reduces pain of single procedures, but its effect on pain from clustered procedures is not known. Aim: The aim was to test Kangaroo Care’s effect on pain in one term infant who received clustered painful procedures while determining feasibility of the Kangaroo Care intervention. Design, Setting, and Participant: A case study design was used with one healthy term newborn who received two heel sticks and one injection in one session in the mother’s postpartum room. Method: Heart rate and oxygen saturation (recorded from Massimo Pulse Oximeter every 30 seconds), crying time (total seconds of crying on videotape) and behavioral state (using Anderson Behavioral State Scoring system every 30 seconds) were measured before (5 minutes), during (10.5 minutes) and after (30 minutes) the three clustered painful procedures in a newborn who was in Kangaroo Care during all observations. One staff nurse administered the clustered procedures. Results: Heart rate increased sequentially with each heelstick, oxygen saturation remained unchanged, sleep predominated, and crying was minimal throughout the procedures. Conclusion: Kangaroo Care appeared to reduce pain from clustered painful procedures and can be further tested. 展开更多
关键词 Kangaroo Care PAIN Clustered Procedures Healthy Term Infant
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Immunotherapy of Malignant Tumors Using Antisense Anti-IGF-I Approach: Case of Glioblastoma 被引量:1
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作者 Annabelle Trojan Lina M. Jay +2 位作者 Heliodor Kasprzak Donald D. Anthony Jerzy Trojan 《Journal of Cancer Therapy》 2014年第7期685-705,共21页
The review article describes the criteria established for methodology of antisense anti IGF-I therapy of malignant tumors, particularly of glioblastoma. The cancer patients, after classical therapy of surgery, radioth... The review article describes the criteria established for methodology of antisense anti IGF-I therapy of malignant tumors, particularly of glioblastoma. The cancer patients, after classical therapy of surgery, radiotherapy and chemotherapy, have undergone the injection of genetically modified autologous malignant cells—transfected by IGF-I antisense/triple helix expression vectors. For all cancer patients supervised for up to 19 months, the period corresponding to minimum survival of glioblastoma patients, the following common immune criteria for “anti IGF-I” strategy were admitted: 1) characteristics of cell “vaccines”—absence of IGF-I and expression of MHC-I in cloned transfected cells;2) the peripheral blood lymphocytes, PBL cells, removed after every of two successive vaccinations, demonstrate an increasing level of CD8+ and CD8+28+ molecules (with a switch from CD8+11b+ to CD8+11b-). 展开更多
关键词 Immunogene Therapy MALIGNANT TUMORS GLIOBLASTOMA IGF-I ANTISENSE
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Gallstone ileus associated with impaction at Meckel's diverticulum:Case report and literature review
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作者 Harveen K Lamba Yiwen Shi Ajita Prabhu 《World Journal of Gastrointestinal Surgery》 SCIE CAS 2016年第11期755-760,共6页
Gallstone ileus due to erosion of one or more gallstones into the gastrointestinal tract is an uncommon cause of small bowel obstruction. The site of impaction is usually distal ileum, and less commonly the jejunum, c... Gallstone ileus due to erosion of one or more gallstones into the gastrointestinal tract is an uncommon cause of small bowel obstruction. The site of impaction is usually distal ileum, and less commonly the jejunum, colon, duodenum, or stomach. We report a rare case of gallstone ileus with impaction at the proximal small bowel and at a Meckel's diverticulum(MD) in a 64-yearold woman managed with laparoscopic converted to open small bowel resections. Patient was discharged home in stable condition and remained asymptomatic at 6-mo follow up. We review the current literature on surgical approaches to MD and gallstone ileus. Diverticulectomy or segmental resection is preferred for complicated MD. For gallstone ileus, simple enterolithotomy or segmental resection are the most the most favored especially in older co-morbid patients due to lower mortality rates and the rarity of recurrent gallstone ileus. In addition, laparoscopy has been increasingly reported as a safe approach to manage gallstone ileus. 展开更多
关键词 Gallstone ileus Meckel’s diverticulum Small bowel obstruction LAPAROSCOPY Cholecystoenteric fistula LAPAROSCOPY
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Spinal cord infarction attributed to SARS-CoV-2, with post-acute sequelae of COVID-19: A case report
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作者 Christina V Oleson Andrew C Olsen Suzanna Shermon 《World Journal of Clinical Cases》 SCIE 2023年第36期8542-8550,共9页
BACKGROUND While stroke and lower extremity venous thromboemboli have been commonly reported following acute infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),spinal cord infarction or ischemi... BACKGROUND While stroke and lower extremity venous thromboemboli have been commonly reported following acute infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),spinal cord infarction or ischemia has been extremely rare.Findings of long coronavirus disease(COVID)in this select population have not been studied.CASE SUMMARY We present the case of a 70-year-old female with sudden onset of trunk and lower extremity sensorimotor loss due to spinal cord infarction,attributed to acute infection with SARS-CoV-2.Diagnostic work up confirmed a T3 complete(ASIA impairment Scale A)paraplegia resulting from a thrombotic infarct.Her reported myalgias,neuropathic pain,spasticity,bladder spasms,and urinary tract infections exceeded the frequency and severity of many spinal cord injury(SCI)individuals of similar age and degree of neurologic impairment.In her first year after contracting COVID-19,she underwent 2 separate inpatient rehabilitation courses,but also required acute hospitalization 6 additional times for subsequent infections or uncontrolled pain.Yet other complications of complete non-traumatic SCI(NTSCI),including neurogenic bowel and temperature hypersens-itivity,were mild,and pressure injuries were absent.She has now transitioned from the acute to chronic phase of spinal cord injury care,with subsequent development of post-acute sequelae of SARS-CoV-2 infection(PASC).CONCLUSION This individual experienced significant challenges with the combined effects of acute T3 NTSCI and acute COVID-19,with subsequent progression to PASC.Core Tip:Although stroke and venous thromboembolism have been frequently observed with acute coronavirus disease 2019(COVID-19),spinal cord infarction leading to paraplegia has rarely been seen.We report a case of spinal cord infarction shortly following infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Consequently,this individual has experienced severe neurologic disability,with subsequent development of long COVID.Symptoms such as myalgias,neuropathic pain,muscle spasms,and frequent bacterial infections are present in post-acute sequelae of SARS-CoV-2 infection(PASC),independent of spinal cord injury(SCI).Over the past 3 years,the dual presence of PASC and recent SCI may have led to increased severity of symptoms shared by both conditions.INTRODUCTION Among vascular events,spinal cord infarction is relatively rare,accounting for only 0.3%-1%of all strokes[1]and 5%-8%of acute myelopathies[2].One cause of spinal cord infarction arises from a thrombotic event in vulnerable areas of the thoracic cord,particularly between T8-12,which is supplied by the artery of Adamkiewicz.While deep vein thrombosis,pulmonary embolism,and stroke are commonly observed complications of coronavirus disease 2019(COVID-19),spinal cord infarction is comparatively infrequent[3-6].The cytokine release following acute infection,which peaks 7 d after contracting the virus,may be responsible for the increase in thrombotic events associated with acute infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)[7,8].This case discussed in this report differs from other published accounts describing spinal cord infarcts attributed to acute SARS-CoV-2,because we have followed this individual for nearly 3 years after contracting COVID-19,covering her difficulties with“long COVID,”which has now officially named post-acute sequelae of SARS-CoV-2 infection(PASC)by the World Health Organization[9].The term PASC may be assigned to“individuals with a history of probable or confirmed SARS-CoV-2 infection,usually 3 mo from the onset of COVID-19 with symptoms that last for at least 2 mo and cannot be explained by an alternative diagnosis”.The definition further states that PASC generally impacts everyday functioning and that symptoms may be of new onset,follow initial recovery from an acute COVID-19 episode,or persist from the initial illness.Moreover,symptoms may also fluctuate or relapse over time[9].Common complaints of PASC include fatigue,cough shortness of breath,cognitive deficits or“brain fog”.Reported features of PASC may also involve headache,heart palpitations,exercise intolerance,joint pain or swelling,myalgias,vertigo,peripheral neuropathy,altered taste or smell,disordered sleep,anxiety,depression,and thromboembolic events[10-13].While a number of the above symptoms may occur subsequent to SCI,many would be unusual,such as persistent cough,fatigue months after SCI,changes in taste or smell,continued exercise intolerance,new onset cognitive deficits or“brain fog”,unrelated to any sedating medications or concomitant brain injury.Our patient became symptomatic prior to COVID-19 vaccine availability and has given written consent to share her story for educational publication.This project was approved by the Institutional Review Board of the MetroHealth System. 展开更多
关键词 Spinal cord infarction PARAPLEGIA COVID-19 SARS-CoV-2 Post-acute
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PRIMARY MALIGNANT MELANOMA OF THE VAGINA:CLINICAL, PATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES OF 9 CASES
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作者 倪型灏 楼洪坤 +1 位作者 楼焕进 李筠 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1993年第3期58-63,共6页
Nine cases of vaginal primary malignant melanoma were diagnosed and treaed in Zhejiang Cancer Hospital from 1964 to 1990. The mean age of patients was 48. 6 years. Abnormal vaginal bleeding was the Incipient symptom i... Nine cases of vaginal primary malignant melanoma were diagnosed and treaed in Zhejiang Cancer Hospital from 1964 to 1990. The mean age of patients was 48. 6 years. Abnormal vaginal bleeding was the Incipient symptom in 6 patients. Five cases of malignant melanoma located in the lower one-third of the vagina. Five patients had the tumor in size larger than or equal to 4 cm In diameter. All of them were of the cauliflower-like, nodular configuration grossly. The surface of the mass demonstrated in a variable degree of black or grey- blackish in 7 patients. The htstological appearances were similar to those in the skin. Sections of 4 cases Indicated only few or no melanin under microscope. The covering epithelial changes of 3 vaginal primary malignant melanoma resembled that of malignant melanoma in situ. All sections of 9 cases showed positive reaction to S-100 protein and negative to CEA immunohistochemically. This article laid emphasis on the origin, diagnosis and treatment of this tumor, and make discussion in conjunction with the literature. 展开更多
关键词 VAGINA Malignant melanoma Immunohtotochemlttry.
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CLINICOPATHOLOGIC ANALYSIS ON 121 CASES OF NASAL AND NASOPHARYNGEAL LYMPHOMA (NPL)
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作者 陆献瑜 吴秋良 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1993年第3期52-57,共6页
One handled twenty- one cases of nasal and naso-pharyngeal lymphoma were analyzed in this paper. These cases were divided macroscopically Into 4 main types Including giant mass type, nodular type, thickbulgy type and ... One handled twenty- one cases of nasal and naso-pharyngeal lymphoma were analyzed in this paper. These cases were divided macroscopically Into 4 main types Including giant mass type, nodular type, thickbulgy type and ulcerating type. Microscopic histologic varieties were classified to non-Hodgkin' s lymphoma (NHL) and Hodg-Kin' s disease (HD).Differential diagnosis between NPL and nasopharyngeal carcinoma (NPC) and the problem how to ascertain the primary and secondary tumors were discussed. 展开更多
关键词 Nasopharyngeal lymphoma ( NFL ) Nasopharyngeal carcinoma (NPC).
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Use of video-assisted thoracoscope in 121 cases of cardiac surgery
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作者 徐学增 俞世强 +4 位作者 程云阁 蔡振杰 段大为 王红兵 陈文生 《Journal of Medical Colleges of PLA(China)》 CAS 2003年第5期321-324,共4页
Objective: To sum up 121 cases of heart disease operations with the help of thoracoscope from May to August in 2000. Among these cases, 48 cases were atrial septal defect (ASD); the average age of patients is 20±... Objective: To sum up 121 cases of heart disease operations with the help of thoracoscope from May to August in 2000. Among these cases, 48 cases were atrial septal defect (ASD); the average age of patients is 20±10 years old; average weight is (43±16) kg. 67 patients with ventricular septal defects (VSD), average age13±9 years old; one male patient, 44 years old with Ebstein malformation; one female patient (21 years old) partial atrioventricular canal combined with cor triatriatum; one male (21 years old) with ruptared aneuryem of aortic sinus. 3 cases(all females ) with mitral stenosis combined with mitral valve incompetence. One male patient(aged 16)with pericardiun effusion after trauma. Methods: During operations, a patient with supine position, and his/her right shoulder was padded 30°higher. Tracheal cannula was inserted and air was piped in with high frequency jet ventilation. Three mini thoracotomies with a diameter of 2 to 3 cm were made in the 4th intercostals space of the right par sternum and the 4th and 7th intercostals spaces of the right middle axillary line respectively. An periphera extra corporeal circulation was made. the aortic clamp was clamped, cannula for cold perfusion. After the heart was sliced and a reformative operation was performed. The process of the operation of defects repairs was finished under the thoracoscope. The other operations were performed with the help of thoracoscope. 3 rheumatic heart disease patients got 25# mechanical mitral valve prosthesis. A 30# tricuspid plasty ring was applied to The Ebstein malformation patient. Results: all 121 patients were successfully operated on without death. Two VSD cases appeared transient third degree atrialventricular block.Because 4 cases had more chest drainage, so they were stanched bleeding twice. After the operation, heart murmur vanished, and ultrasonic inspection showed no diffluence inside the heart. Conclusion: Our experience showed that all atrium, ventricular septal defects can be repaired under the thoracoscope. This scope-assisted technology is more accepted by patients because of tiny incisions and also provides an alternative solution for cardiac surgeons. 展开更多
关键词 thoracoscope atrial septal defect ventricular septal defect mitral valve replacement
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IMMUNOLOGICAL DIAGNOSIS OF LIGHT CHAIN DISEASE ANALYSIS OF 11 CASES FOUND IN FUJIAN PROVINCE
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作者 邱文宣 吴国华 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1993年第1期67-72,共6页
The present paper reports 11 cases of light chain disease (LCD) sequently found in several citles over Fujian province, Immunological classification of this group of LCD ww as follows: six of me cases belonged to type... The present paper reports 11 cases of light chain disease (LCD) sequently found in several citles over Fujian province, Immunological classification of this group of LCD ww as follows: six of me cases belonged to type λ, four of them were type κ, and another one was a double LCD. We found that LCD was common in Fujlan only next to multiple myeloma (MM) of IgG class and accounted for 20% of the total 55 MM cases found in recent yean.It to well known that In matt patients of LCD M protein or Bence Jones proteinemia (BJPemia) to not detectable by conventional electro-phoresis. Our studies show that by making serum protein along with urinary BJP electrophoresis on the same one gel plate the sltuation can be greatly Improved It not only favour* the recognition of smail and faint band or bands of free light chain in serum, but also provides a repid and sensitive way, i. e. , immunofixation, to directly detect urinary light chain on the gel plate Immediately after electrophresis has been run. 展开更多
关键词 Multiple myeloma Light chain disease Immunological diagnosis.
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The Clinical and Angiograghic Outcome of 190 Cases after Stent Placement in Small Coronary Vessels
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作者 郭文怡 贾国良 +6 位作者 李伟杰 秦涛 李成祥 栾荣华 吕安林 王小燕 李媛 《South China Journal of Cardiology》 CAS 2003年第2期63-65,共3页
Objectives To invest the success procedure, immediate outcome after procedure, the rate of main adverse cardiac events after procedure and restenosis after stent placement in small coronary vessels. Methods 290 patien... Objectives To invest the success procedure, immediate outcome after procedure, the rate of main adverse cardiac events after procedure and restenosis after stent placement in small coronary vessels. Methods 290 patients with selected or emergency stent implantation in small vessels from April, 1997 to March,2002. Total 299 vessels,304 lesions and 316 stents were statisted. The successs rate of procedure, immediate outcome after procedure, the rate of main adverse cardiac events after procedure and restenosis after stent placement in small coronary vessels were assessed. The patients were followed up 1 month to 4 years. Re-catheter angiography were done in 122/290 patients. Results The narrow rate of lesion dropped from 89% ± 12% before procedure to 5% ±5% after procedure (diameter). 202 patients were followed up 1 month (69.7%). 197/202 cases were survival. 5/202 cases died in 3hrs to 7days. 2/5 cases died of persistent hypotension after procedure. 1/5 case died of acute left heart failure. 2/5 cases died of sudden death. 180 cases were followed up 5 months to 4 years. The non-event survival (NES) rate was 73.3% (132/180). The re-angiography were done in 122 cases. Restenosis happened in 39 cases (30.3%). 37 patients repeated PCI. 2 patients went to CABG. 2 cases got angina recurrence and were proved second time restenosis by re-angiography. The third time PCI was done in 1 patient. The other patients went to CABG. 1 case died of chronic heart failure after 2 years, 1 case suffered acute myocardial infarction on artery stent implanted. Conclusions There are high success rate of procedure and perfect immediate outcome in stent placement in small vessels. Main adverse cardiac events did not increased. Non-event survial was satisfied in long term follow -up. Restenosis rate was showed slightly higher than the one of main vessels. 展开更多
关键词 Small vessels Stent PCI
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CLEAR CELL CHONDROSARCOMA OF BONE (A REPORT OF THREE CASES WITH IMMUNOHISTOCHEMICAL AND AFFINITY HISTOCHEMICAL OBSERVATIONS)
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作者 王连唐 刘子君 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1993年第1期16-21,共6页
Clear cell chondrosarcoma, a subtype and separate entity from the traditional chondrosarcoma, is characterized by its special histologic features, site of predilection, slow growth and better prognosis. Three cases ar... Clear cell chondrosarcoma, a subtype and separate entity from the traditional chondrosarcoma, is characterized by its special histologic features, site of predilection, slow growth and better prognosis. Three cases are presented with elucidation of clinicopathologic correlation and detection by the ABC immunohistochemical method using several antibodies. The observation of positive reaction to S-100 pretein (S-100), vimentin(Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. It was found for the first time that the clear cell chondrosarcoma was positive for wheat germ agglutinin (WGA) and concanavalin A (Con A). The authors believe that clear cell chondrosarcoma may result from the anaplastic changes of chondroblastoma cells Into another subtype of that tumor. The osteoclast-like multinucleated giant cells (MGC), retaining the antigens of phagocytes, are not considered to be neoplastic. 展开更多
关键词 Clear cell chondrosarcoma Traditional chondrosarcoma CHONDROBLASTOMA Technology of Immunohlttochemistry Lectins.
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儿童新型冠状病毒感染并发纵隔气肿八例影像学及临床特点研究
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作者 付强 任作雷 +5 位作者 林志强 龚剑峰 王长征 王婷 胡雅兰 谭举方 《中国全科医学》 CAS 北大核心 2025年第4期510-515,共6页
背景儿童新型冠状病毒感染(COVID-19)影像学与成人有一定差异,主要表现为胸膜下磨玻璃影、斑片状高密度影、实变影等,合并纵隔气肿者并不多见。大量气肿形成可严重影响呼吸及循环功能,导致明显喘憋、低氧血症,需积极处理。目的分析并总... 背景儿童新型冠状病毒感染(COVID-19)影像学与成人有一定差异,主要表现为胸膜下磨玻璃影、斑片状高密度影、实变影等,合并纵隔气肿者并不多见。大量气肿形成可严重影响呼吸及循环功能,导致明显喘憋、低氧血症,需积极处理。目的分析并总结儿童COVID-19并发纵隔气肿的影像学及临床特征。方法回顾分析2022-12-01—2023-01-30在长江大学附属荆州医院儿科住院的8例COVID-19并发纵隔气肿的患儿年龄、性别、影像学、临床特点及诊疗情况。结果8例患儿年龄3岁7个月~12岁,男女比3∶5,高分辨率CT(HRCT)均显示双肺感染合并纵隔气肿。气肿多同时累及颈部及胸壁。肺部表现多种多样:胸膜下磨玻璃影、实变、树芽征、支气管血管束增粗、支气管壁增厚及网格征等,未见大片实变及“白肺”。1例患儿合并少量胸腔积液。临床表现除有发热、咳嗽外,均有明显气促,肺部听诊干湿啰音可不显著。4例合并肺炎支原体感染、1例合并卡他布兰汉菌感染。合并肺炎支原体感染者应用阿奇霉素,合并卡他布兰汉菌感染者给予头孢噻肟治疗。8例患儿均给予氧疗。1例患儿白细胞总数及超敏C反应蛋白明显升高,明显气急,低氧血症,常规治疗无好转,给予有创呼吸机治疗3d后好转撤机。5例应用静脉丙种球蛋白(IVIG),3例使用糖皮质激素。1周后复查胸部CT,纵隔气肿均完全吸收,肺部病灶明显好转。结论COVID-19并发纵隔气肿者多为学龄前期或学龄期儿童,婴幼儿少见。可同时合并颈部及胸壁积气。肺部病变可累及间质或实质、双肺均受累,表现形式多样。起病多有明显气急,积极氧疗。白细胞计数明显升高,同时超敏C反应蛋白明显升高者,要密切关注呼吸情况,积极使用IVIG,适时适量应用糖皮质激素,必要时采用呼吸机人工辅助通气。 展开更多
关键词 新型冠状病毒感染 纵隔气肿 临床特征 体层摄影术 螺旋计算机 儿童
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