Objectives: To assess the efficiency in terms of cost-effectiveness (CE) of oral Renalof® treatment versus extracorporeal shockwave lithotripsy (ESWL) in the treatment of kidney stones ≤ 1 cm in Nicaragua. Metho...Objectives: To assess the efficiency in terms of cost-effectiveness (CE) of oral Renalof® treatment versus extracorporeal shockwave lithotripsy (ESWL) in the treatment of kidney stones ≤ 1 cm in Nicaragua. Methods: A cost-effectiveness economic evaluation was carried out based on the results obtained in the randomised, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the incremental cost-effectiveness ratio (ICER) were calculated. Economic data were obtained from the Economics Department of Clínica Senior in Managua, Nicaragua. The monetary cost was expressed in US dollars (USD). Results: Treatment with Renalof® yielded a CE of $1,323.08/% remission, while ESWL was $9,498.54/% remission. The ICER shows that, in order to achieve a high percentage of kidney stone remission with ESWL, an extra $4,734.70 per patient must be invested. Conclusions: The use of Renalof® is shown to be a more cost-effective option than ESWL. It is recommended for the treatment of kidney stones ≤ 1 cm in size.展开更多
Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects ...Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of this clinical trial is to study the effectiveness of Spermotrend in the improvement of sperm parameters in male infertility. Methods: A total of 170 males aged > 18 years with a diagnosis of infertility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours for 6 months and was evaluated through semen analysis at 4 and 6 months of follow-up. Results: The trial results show a significant improvement following the administration of Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of the study, 55.3% of patients had normal venous flow and dilation. Only 5.9% of the patients showed grade 2 varicocele at the end of the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of the patients completed the study with normalized testicular volume by recovering normal venous flow. Conclusion: A short-term course of Spermotrend may significantly improve sperm parameters associated with male infertility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ClinicalTrials.gov, with the code: NCT05222841 on 15/06/2021.展开更多
Background: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Treatment of AD is based on skin barrier repair and reduction of inflammation. We analyzed the efficacy and safety of activa...Background: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Treatment of AD is based on skin barrier repair and reduction of inflammation. We analyzed the efficacy and safety of activated piroctone olamine (APO)—Blue Cap—in children with AD. Materials and Methods: An open-label interventional clinical study was carried out at three clinical centers in Serbia. A total of 58 patients with AD, aged between 3 and 18 years were included and treated with Blue Cap Foam (100 ml;CATALYSIS S.L. Madrid)—Activated Piroctone Olamine—applied twice a day in the affected areas with eczema for 30 days and final assessment at 45 days from baseline. Photographic documentation, clinical evaluation, therapy effectiveness and safety questionnaires were assessed at baseline, 15, 30 and 45 days. Results: Our results demonstrated a significant reduction in signs (erythema, scaling, infiltration, excoriations, xerosis) and symptoms (pruritus) at weeks 2 and 4 of the study. At the end of the study, most patients had moderate (28.6%) to great (62.5%) disappearance of manifestations and moderate (25%) to great (71.4%) skin quality improvement. The effect and tolerability of the therapy were evaluated as very good in 66.1 % and 67.9% and good in about 14.3% and 17.9%, assessed by the investigator and patient, respectively. Three patients experienced a burning sensation at the beginning of the study, the side-effects were resolved as the patients continued applying the foam. After two weeks of cessation of the investigated foam, a significant percentage of patients experienced worsening in the final assessment done by the investigator as well as the participant. In the final assessment, a significantly high percentage (57.1%) of patients had a total reduction of manifestation, and a significant number of participants considered the applied product as treatment success, assessed by the investigator (62.5%) as well as the participants (66.4%). Conclusions: Blue Cap is effective and safe in children with AD, although further large-scale randomized controlled trials should confirm our study findings.展开更多
The objective of this research was to evaluate the impact of the VIUSID Vet(powder and solution)nutritional supplement on the productive performance of growing-finishing pigs.Two experiments were conducted,each using ...The objective of this research was to evaluate the impact of the VIUSID Vet(powder and solution)nutritional supplement on the productive performance of growing-finishing pigs.Two experiments were conducted,each using 210 pigs at an average age of 40 d—70 per treatment—which were distributed into 15 pens(five per group).The experiments lasted 170 d.The treatments consisted in:Experiment 1,Group I control group;Group II received from the start 1.5 g of VIUSID Vet powder per kilogram of feed daily for 90 d;Group III same as the former,but instead given 2.0 g.Experiment 2,Group I control;Group II received from the start 1.5 g of VIUSID Vet powder per kilogram of feed daily for 90 d;Group III same as the former,but instead given 1.5 mL of VIUSID Vet solution per kilogram of feed.VIUSID Vet(powder or solution)significantly improved weight gain and feed conversion as well as reduced deaths when given doses of 2.0 g and 1.5 g or 1.5 mL per kilogram of feed during the first 90 d of the growing-finishing phase,giving rise to financial benefits.展开更多
With the objective of evaluating the effect of VIUSID agro on the morphophysiological and productive performance of tobacco seedlings,a randomised block experiment was designed with five treatments and three replicati...With the objective of evaluating the effect of VIUSID agro on the morphophysiological and productive performance of tobacco seedlings,a randomised block experiment was designed with five treatments and three replications.The variants were:dosage of 0.2,0.5,0.7 and 1.0 L/ha and one control.The variables are recorded at three points of the cultivation cycle 10th,20th and 30th days after planting(DAP).Among the indicators evaluated were the fresh and dry mass of the plants,the leaves per plant,foliar area,the length and diameter of the stalk as well as the characteristics of the root.The rates of physiological growth and agricultural yield were also evaluated.The results showed a significant increase(p≤0.05)in the fresh and dry mass of the plants when VIUSID was used.Regarding the length of the stalk,the average increases of those treated in comparison to the control in the final evaluation were 28.42%,30.51%,41.17%and 38.43%.In terms of the diameter of the stalk and the foliar area in all evaluations,the treatments with VIUSID significantly exceeded the control.The absolute growth rate and net assimilation was significantly higher when the product was used.In the relative growth rate,the most favourable behaviour was the dosage of 0.5 L/ha,in final evaluation.With regard to yield,the best performance with significant differences(p≤0.05)to the other treatments was the dosage of 0.5,0.7 and 1.0 L/ha.Therefore,VIUSID agro had a positive influence on the morphophysiological and productive indicators of the tobacco seedlings.展开更多
In order to evaluate the effect of VIUSID agro on the yield response of a pak choi harvest,a randomised block experiment was designed with four treatments and three replications.The treatments were dosages of 0.1,0.2 ...In order to evaluate the effect of VIUSID agro on the yield response of a pak choi harvest,a randomised block experiment was designed with four treatments and three replications.The treatments were dosages of 0.1,0.2 and 0.3 L/ha and one control.The number of leaves per plant and the fresh and dry mass of the plant were measured.In addition,growth indexes were evaluated,such as relative growth rate,active growth rate,harvest index and agricultural yield.The number of leaves per plant was significantly greater at 35 days after sowing(das)for 0.2 L/ha and 0.3 L/ha treatments,with increases of 15.0%and 14.17%relative to the control.Regarding plant length and fresh mass at the final evaluation,the treatments using higher dosages produced the best results.Regarding the active growth rate,the 0.2 L/ha dosage produced the best effects,and regarding relative growth rate,the 0.2 L/ha and 0.3 L/ha dosages produced the best results relative to the control.The harvest index did not benefit from the used dosages,while a higher agricultural yield was achieved using the 0.2 L/ha and 0.3 L/ha dosages at 18.03%and 12.88%compared to the control.Therefore,VIUSID agro positively influenced the yield behaviour of pak choi.展开更多
文摘Objectives: To assess the efficiency in terms of cost-effectiveness (CE) of oral Renalof® treatment versus extracorporeal shockwave lithotripsy (ESWL) in the treatment of kidney stones ≤ 1 cm in Nicaragua. Methods: A cost-effectiveness economic evaluation was carried out based on the results obtained in the randomised, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the incremental cost-effectiveness ratio (ICER) were calculated. Economic data were obtained from the Economics Department of Clínica Senior in Managua, Nicaragua. The monetary cost was expressed in US dollars (USD). Results: Treatment with Renalof® yielded a CE of $1,323.08/% remission, while ESWL was $9,498.54/% remission. The ICER shows that, in order to achieve a high percentage of kidney stone remission with ESWL, an extra $4,734.70 per patient must be invested. Conclusions: The use of Renalof® is shown to be a more cost-effective option than ESWL. It is recommended for the treatment of kidney stones ≤ 1 cm in size.
文摘Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of this clinical trial is to study the effectiveness of Spermotrend in the improvement of sperm parameters in male infertility. Methods: A total of 170 males aged > 18 years with a diagnosis of infertility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours for 6 months and was evaluated through semen analysis at 4 and 6 months of follow-up. Results: The trial results show a significant improvement following the administration of Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of the study, 55.3% of patients had normal venous flow and dilation. Only 5.9% of the patients showed grade 2 varicocele at the end of the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of the patients completed the study with normalized testicular volume by recovering normal venous flow. Conclusion: A short-term course of Spermotrend may significantly improve sperm parameters associated with male infertility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ClinicalTrials.gov, with the code: NCT05222841 on 15/06/2021.
文摘Background: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Treatment of AD is based on skin barrier repair and reduction of inflammation. We analyzed the efficacy and safety of activated piroctone olamine (APO)—Blue Cap—in children with AD. Materials and Methods: An open-label interventional clinical study was carried out at three clinical centers in Serbia. A total of 58 patients with AD, aged between 3 and 18 years were included and treated with Blue Cap Foam (100 ml;CATALYSIS S.L. Madrid)—Activated Piroctone Olamine—applied twice a day in the affected areas with eczema for 30 days and final assessment at 45 days from baseline. Photographic documentation, clinical evaluation, therapy effectiveness and safety questionnaires were assessed at baseline, 15, 30 and 45 days. Results: Our results demonstrated a significant reduction in signs (erythema, scaling, infiltration, excoriations, xerosis) and symptoms (pruritus) at weeks 2 and 4 of the study. At the end of the study, most patients had moderate (28.6%) to great (62.5%) disappearance of manifestations and moderate (25%) to great (71.4%) skin quality improvement. The effect and tolerability of the therapy were evaluated as very good in 66.1 % and 67.9% and good in about 14.3% and 17.9%, assessed by the investigator and patient, respectively. Three patients experienced a burning sensation at the beginning of the study, the side-effects were resolved as the patients continued applying the foam. After two weeks of cessation of the investigated foam, a significant percentage of patients experienced worsening in the final assessment done by the investigator as well as the participant. In the final assessment, a significantly high percentage (57.1%) of patients had a total reduction of manifestation, and a significant number of participants considered the applied product as treatment success, assessed by the investigator (62.5%) as well as the participants (66.4%). Conclusions: Blue Cap is effective and safe in children with AD, although further large-scale randomized controlled trials should confirm our study findings.
文摘The objective of this research was to evaluate the impact of the VIUSID Vet(powder and solution)nutritional supplement on the productive performance of growing-finishing pigs.Two experiments were conducted,each using 210 pigs at an average age of 40 d—70 per treatment—which were distributed into 15 pens(five per group).The experiments lasted 170 d.The treatments consisted in:Experiment 1,Group I control group;Group II received from the start 1.5 g of VIUSID Vet powder per kilogram of feed daily for 90 d;Group III same as the former,but instead given 2.0 g.Experiment 2,Group I control;Group II received from the start 1.5 g of VIUSID Vet powder per kilogram of feed daily for 90 d;Group III same as the former,but instead given 1.5 mL of VIUSID Vet solution per kilogram of feed.VIUSID Vet(powder or solution)significantly improved weight gain and feed conversion as well as reduced deaths when given doses of 2.0 g and 1.5 g or 1.5 mL per kilogram of feed during the first 90 d of the growing-finishing phase,giving rise to financial benefits.
文摘With the objective of evaluating the effect of VIUSID agro on the morphophysiological and productive performance of tobacco seedlings,a randomised block experiment was designed with five treatments and three replications.The variants were:dosage of 0.2,0.5,0.7 and 1.0 L/ha and one control.The variables are recorded at three points of the cultivation cycle 10th,20th and 30th days after planting(DAP).Among the indicators evaluated were the fresh and dry mass of the plants,the leaves per plant,foliar area,the length and diameter of the stalk as well as the characteristics of the root.The rates of physiological growth and agricultural yield were also evaluated.The results showed a significant increase(p≤0.05)in the fresh and dry mass of the plants when VIUSID was used.Regarding the length of the stalk,the average increases of those treated in comparison to the control in the final evaluation were 28.42%,30.51%,41.17%and 38.43%.In terms of the diameter of the stalk and the foliar area in all evaluations,the treatments with VIUSID significantly exceeded the control.The absolute growth rate and net assimilation was significantly higher when the product was used.In the relative growth rate,the most favourable behaviour was the dosage of 0.5 L/ha,in final evaluation.With regard to yield,the best performance with significant differences(p≤0.05)to the other treatments was the dosage of 0.5,0.7 and 1.0 L/ha.Therefore,VIUSID agro had a positive influence on the morphophysiological and productive indicators of the tobacco seedlings.
文摘In order to evaluate the effect of VIUSID agro on the yield response of a pak choi harvest,a randomised block experiment was designed with four treatments and three replications.The treatments were dosages of 0.1,0.2 and 0.3 L/ha and one control.The number of leaves per plant and the fresh and dry mass of the plant were measured.In addition,growth indexes were evaluated,such as relative growth rate,active growth rate,harvest index and agricultural yield.The number of leaves per plant was significantly greater at 35 days after sowing(das)for 0.2 L/ha and 0.3 L/ha treatments,with increases of 15.0%and 14.17%relative to the control.Regarding plant length and fresh mass at the final evaluation,the treatments using higher dosages produced the best results.Regarding the active growth rate,the 0.2 L/ha dosage produced the best effects,and regarding relative growth rate,the 0.2 L/ha and 0.3 L/ha dosages produced the best results relative to the control.The harvest index did not benefit from the used dosages,while a higher agricultural yield was achieved using the 0.2 L/ha and 0.3 L/ha dosages at 18.03%and 12.88%compared to the control.Therefore,VIUSID agro positively influenced the yield behaviour of pak choi.
