AIM: To study the potential reasons of increased straylight in pseudophakic eyes. METHODS: Cross -sectional study. Seventy patients diagnosed as bilateral age-related cataract and implanted with Tecnis ZA9003, Sensar ...AIM: To study the potential reasons of increased straylight in pseudophakic eyes. METHODS: Cross -sectional study. Seventy patients diagnosed as bilateral age-related cataract and implanted with Tecnis ZA9003, Sensar AR40e, SA6OAT, XLSTABI ZO or Akeros AO intraocular lens (IOL) were enrolled in this research. Straylight was measured by a C -Quant straylight meter three to four weeks postoperatively. Five different modalities of IOL, including spherical/aspherical optics and hydrophobic/hydrophilic material were tested in this study. Normal as well as dilated pupils were used. The main outcome variable for straylight measurement was the logarithmic straylight parameter, log(s). RESULTS: The straylight parameter increased significantly after pupil dilation (P<0.05). Straylight of aspherical IOL was significantly higher after pupil dilation (P<0.06) compared to spherical IOL. In normal pupil, straylight of hydrophobic IOL was significant higher when compared with hydrophilic IOL (P<0.05). CONCLUSION: Straylight and visual acuity stand for the different aspects of visual function. Several factors including pupil diameter, optic material, aspherical design of IOL influence intraocular light scattering in pseudophakic eyes. Further investigation was needed to study the impact of optic material and optic surface design on pseudophakic straylight.展开更多
Direct exposure to intensive visible light can lead to solar retinopathy, including macular injury. The signs and symptoms include central scotoma, metamorphopsia, and decreased vision. However, there have been few st...Direct exposure to intensive visible light can lead to solar retinopathy, including macular injury. The signs and symptoms include central scotoma, metamorphopsia, and decreased vision. However, there have been few studies examining retinal injury due to intensive light stimulation at the cellular level. Neural network arrangements and gene expression patterns in zebrafish photoreceptors are similar to those observed in humans, and photoreceptor injury in zebrafish can induce stem cell-based cellular regeneration. Therefore, the zebrafish retina is considered a useful model for studying photoreceptor injury in humans. In the current study, the central retinal photoreceptors of zebrafish were selectively ablated by stimulation with high-intensity light. Retinal injury, cell proliferation and regeneration of cones and rods were assessed at 1, 3 and 7 days post lesion with immunohistochemistry and in situ hybridization. Additionally, a light/dark box test was used to assess zebrafish behavior. The results revealed that photoreceptors were regenerated by 7 days after the light-induced injury. However, the regenerated cells showed a disrupted arrangement at the lesion site. During the injury-regeneration process, the zebrafish exhibited reduced locomotor capacity, weakened phototaxis and increased movement angular velocity. These behaviors matched the morphological changes of retinal injury and regeneration in a number of ways. This study demonstrates that the zebrafish retina has a robust capacity for regeneration. Visual impairment and stress responses following high-intensity light stimulation appear to contribute to the alteration of behaviors.展开更多
Purpose:Effect of intravenous sedation on patients’visual experience and vital signs during cataract surgery under topical anesthesia:a randomized controlled trial.Design:Prospective,double masked,randomized controll...Purpose:Effect of intravenous sedation on patients’visual experience and vital signs during cataract surgery under topical anesthesia:a randomized controlled trial.Design:Prospective,double masked,randomized controlled trial.Methods:150 eyes of 150 patients undergoing phacoemulsification and IOL implantation under topical anesthesia were randomized to receive either intravenous midazolam(0.015 mg/kg)or normal saline.The patients’experience was evaluated using a questionnaire.Vital signs including blood pressure and heart rate were measured before,during and after surgery.Mean arterial pressure(MAP)was calculated.Results:Both groups were comparable except that fewer patients in the control group were pseudophakic in the fellow eye(25.3%vs.41.3%).More patients in the control group perceived hand movements(p<0.01),surgeon/medical staff(p?0.04)and sudden increase in vision during surgery(p<0.01)compared to midazolam group.More control group patients experienced fear(p<0.001),pain(p=0.06)and unpleasant surgical experience(20.3%vs.1.3%,p<0.001).They also experienced greater fluctuation in MAP(16.9±7.9 vs.7.2±5.3,p<0.001)and this was accentuated in hypertensives.After adjusting for age,gender,hypertension status and other eye lens status,multivariable logistic regression analysis revealed that subjects in the control arm(OR=11.7,95%[CI]=1.3-108,p=0.03),had a longer duration of surgery,experienced pain and more likely to report unpleasant experience.Adjusting for similar covariates,multivariable linear regression analysis showed that control group patients(β=8.5 mmHg,95%CI=6.2-10.8,p=0.03)had hypertension,experienced fear during surgery and greater fluctuations in the MAP.Conclusions:A sedative dose of intravenous midazolam during phacoemulsification under topical anesthesia significantly reduces patients’visual experience,fear and fluctuations in MAP and improves overall surgical experience.展开更多
文摘AIM: To study the potential reasons of increased straylight in pseudophakic eyes. METHODS: Cross -sectional study. Seventy patients diagnosed as bilateral age-related cataract and implanted with Tecnis ZA9003, Sensar AR40e, SA6OAT, XLSTABI ZO or Akeros AO intraocular lens (IOL) were enrolled in this research. Straylight was measured by a C -Quant straylight meter three to four weeks postoperatively. Five different modalities of IOL, including spherical/aspherical optics and hydrophobic/hydrophilic material were tested in this study. Normal as well as dilated pupils were used. The main outcome variable for straylight measurement was the logarithmic straylight parameter, log(s). RESULTS: The straylight parameter increased significantly after pupil dilation (P<0.05). Straylight of aspherical IOL was significantly higher after pupil dilation (P<0.06) compared to spherical IOL. In normal pupil, straylight of hydrophobic IOL was significant higher when compared with hydrophilic IOL (P<0.05). CONCLUSION: Straylight and visual acuity stand for the different aspects of visual function. Several factors including pupil diameter, optic material, aspherical design of IOL influence intraocular light scattering in pseudophakic eyes. Further investigation was needed to study the impact of optic material and optic surface design on pseudophakic straylight.
基金supported by the National Natural Science Foundation of China,No.81301080,81671179the Fundamental Research Funds for the Central Universities in China,No.63161215the Natural Science Foundation of Tianjin of China,No.15JCYBJC24400,15JCQNJC10900
文摘Direct exposure to intensive visible light can lead to solar retinopathy, including macular injury. The signs and symptoms include central scotoma, metamorphopsia, and decreased vision. However, there have been few studies examining retinal injury due to intensive light stimulation at the cellular level. Neural network arrangements and gene expression patterns in zebrafish photoreceptors are similar to those observed in humans, and photoreceptor injury in zebrafish can induce stem cell-based cellular regeneration. Therefore, the zebrafish retina is considered a useful model for studying photoreceptor injury in humans. In the current study, the central retinal photoreceptors of zebrafish were selectively ablated by stimulation with high-intensity light. Retinal injury, cell proliferation and regeneration of cones and rods were assessed at 1, 3 and 7 days post lesion with immunohistochemistry and in situ hybridization. Additionally, a light/dark box test was used to assess zebrafish behavior. The results revealed that photoreceptors were regenerated by 7 days after the light-induced injury. However, the regenerated cells showed a disrupted arrangement at the lesion site. During the injury-regeneration process, the zebrafish exhibited reduced locomotor capacity, weakened phototaxis and increased movement angular velocity. These behaviors matched the morphological changes of retinal injury and regeneration in a number of ways. This study demonstrates that the zebrafish retina has a robust capacity for regeneration. Visual impairment and stress responses following high-intensity light stimulation appear to contribute to the alteration of behaviors.
文摘目的比较小切口飞秒激光角膜基质透镜取出术(Small incision lenticule extraction,SMILE)与飞秒激光辅助的 LASIK(Femtosecond laser-assisted laser in situ keratomileusis,FS-LASIK)矫正近视及近视散光术后24 h内疗效。方法行SMILE的近视患者18例(36眼),同期行FS-LASIK者15例(30眼),记录术前以及术后2、4、6、24 h的裸眼视力(Uncorrected visual acuity,UCVA)、等效球镜(Spherical equivalent,SE)、角膜光密度(Corneal densitometry,CD)、中央角膜厚度(Central corneal thickness,CCT)等。结果 SMILE组术后2 h 36眼中有17%≤0.1 logMAR UCVA,术后4、6、24 h 分别有22%、47%、92%≤0.1 logMAR UCVA;FS-LASIK组术后2 h 30眼中有10%≤0.1 logMAR UCVA,术后4、6、24 h 分别有30%、57%、90%≤0.1 logMAR UCVA。两组差异无统计学意义( P >0.05);两组术后24 h内屈光残留均在(±1.00D),两组比较术后各时间点SE无统计学差异( P >0.05)。两组术后平均角膜光密度均较术前显著增加( P <0.05),均在术后2h平均角膜光密度最大,术后4、6、24 h逐渐减小,两组比较无统计学意义( P >0.05);两组术后中央角膜厚度均随时间推移逐渐变薄,组内各时间点比较差异有统计学意义( P <0.05),组间比较无统计学差异( P >0.05)。结论 SMILE与FS-LASIK治疗近视和散光在术后最初24 h内视力和角膜状态均能快速恢复。该结果对于SMILE和FS-LASIK术后早期疗效的评估,尤其是对于具有迫切体检需求的患者,具有一定的参考意义。
文摘Purpose:Effect of intravenous sedation on patients’visual experience and vital signs during cataract surgery under topical anesthesia:a randomized controlled trial.Design:Prospective,double masked,randomized controlled trial.Methods:150 eyes of 150 patients undergoing phacoemulsification and IOL implantation under topical anesthesia were randomized to receive either intravenous midazolam(0.015 mg/kg)or normal saline.The patients’experience was evaluated using a questionnaire.Vital signs including blood pressure and heart rate were measured before,during and after surgery.Mean arterial pressure(MAP)was calculated.Results:Both groups were comparable except that fewer patients in the control group were pseudophakic in the fellow eye(25.3%vs.41.3%).More patients in the control group perceived hand movements(p<0.01),surgeon/medical staff(p?0.04)and sudden increase in vision during surgery(p<0.01)compared to midazolam group.More control group patients experienced fear(p<0.001),pain(p=0.06)and unpleasant surgical experience(20.3%vs.1.3%,p<0.001).They also experienced greater fluctuation in MAP(16.9±7.9 vs.7.2±5.3,p<0.001)and this was accentuated in hypertensives.After adjusting for age,gender,hypertension status and other eye lens status,multivariable logistic regression analysis revealed that subjects in the control arm(OR=11.7,95%[CI]=1.3-108,p=0.03),had a longer duration of surgery,experienced pain and more likely to report unpleasant experience.Adjusting for similar covariates,multivariable linear regression analysis showed that control group patients(β=8.5 mmHg,95%CI=6.2-10.8,p=0.03)had hypertension,experienced fear during surgery and greater fluctuations in the MAP.Conclusions:A sedative dose of intravenous midazolam during phacoemulsification under topical anesthesia significantly reduces patients’visual experience,fear and fluctuations in MAP and improves overall surgical experience.
