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Highly Weak-light Sensitive and Dual-band Switchable Photodetector Based on CuI/Si Unilateral Heterojunction
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作者 YANG Jialin WANG Liangjun +2 位作者 RUAN Siyuan JIANG Xiulin YANG Chang 《无机材料学报》 SCIE EI CAS CSCD 北大核心 2024年第9期1063-1069,共7页
In recent years,copper iodide(CuI)is an emerging p-type wide bandgap semiconductor with high intrinsic Hall mobility,high optical absorption and large exciton binding energy.However,the spectral response and the photo... In recent years,copper iodide(CuI)is an emerging p-type wide bandgap semiconductor with high intrinsic Hall mobility,high optical absorption and large exciton binding energy.However,the spectral response and the photoelectric conversion efficiency are limited for CuI-based heterostructure devices,which is related to the difficulty in fabrication of high-quality CuI thin films on other semiconductors.In this study,a p-CuI/n-Si photodiode has been fabricated through a facile solid-phase iodination method.Although the CuI thin film is polycrystalline with obvious structural defects,the CuI/Si diode shows a high weak-light sensitivity and a high rectification ratio of 7.6×10^(4),indicating a good defect tolerance.This is because of the unilateral heterojunction behavior of the formation of the p^(+)n diode.In this work,the mechanism of photocurrent of the p^(+)n diode has been studied comprehensively.Different monochromatic lasers with wavelengths of 400,505,635 and 780 nm have been selected for testing the photoresponse.Under zero-bias voltage,the device is a unilateral heterojunction,and only visible light can be absorbed at the Si side.On the other hand,when a bias voltage of-3 V is applied,the photodiode is switched to a broader“UV-visible”band response mode.Therefore,the detection wavelength range can be switched between the“Visible”and“UV-visible”bands by adjusting the bias voltage.Moreover,the obtained CuI/Si diode was very sensitive to weak light illumination.A very high detectivity of 10^(13)-1014 Jones can be achieved with a power density as low as 0.5μW/cm^(2),which is significantly higher than that of other Cu-based diodes.These findings underscore the high application potential of CuI when integrated with the traditional Si industry. 展开更多
关键词 er iodide HETEROJUNCTION PHOTODETECTOR
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SYNTHESIS, CHARACTERIZATION AND APPLICATION IN PEMFC OF ZIRCONIUM OXO PHOSPHATE-SULFATE
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作者 吴宗斌 于景荣 +3 位作者 刘中民 田鹏 杨越 许磊 《化工学报》 EI CAS CSCD 北大核心 2004年第S1期238-244,共7页
Mesoporous zirconium oxo phosphate-sulfate was synthesized by hydrothermal method with hexadecyltrithylammonium bromide(CTAB)as the template and with zirconium nitrate or zirconium oxychloride as zirconium source.The ... Mesoporous zirconium oxo phosphate-sulfate was synthesized by hydrothermal method with hexadecyltrithylammonium bromide(CTAB)as the template and with zirconium nitrate or zirconium oxychloride as zirconium source.The optimum two-stage process was established, ^(31)P MAS NMR showed that the states of phosphate species were changed with further postsynthesis treatment by sulfate acid. The transformations of the structures at different temperatures from room temperature to 1173 K were investigated by XRD. ... 展开更多
关键词 zirconium oxo phosphate-sulfate recast composite membrane PEMFC
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BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response
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作者 Zhenhai Li Wenchao Xu +2 位作者 Feng Chen Jun Zhang Wei-Guo Zhu 《Genes & Diseases》 SCIE CSCD 2024年第1期19-22,共4页
Etoposide is widely used for cancer chemotherapy in the clinic.However,long-term etoposide treatment can lead to adverse effects or drug resistance.To improve the situation,we evaluated the therapeutic efficiency of e... Etoposide is widely used for cancer chemotherapy in the clinic.However,long-term etoposide treatment can lead to adverse effects or drug resistance.To improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer development.Firstly,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway. 展开更多
关键词 ETOPOSIDE DAMAGE cancer
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A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants bytargeting the upstream region of spike protein HR2 motif
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作者 Hang Su Jun Zhang +13 位作者 Zhenfei Yi Sajid Khan Mian Peng Liang Ye Alan Bao Han Zhang Guangli Suo Qian Li Housheng Zheng Dandan Wu Thomas J.Kipps Lanfeng Wang Zhenghong Lin Suping Zhang 《hLife》 2024年第3期126-140,共15页
The continuous emergence of new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants meansthere is a need to explore additional strategies to develop broad-spectrum vaccines or therapeutics for individu... The continuous emergence of new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants meansthere is a need to explore additional strategies to develop broad-spectrum vaccines or therapeutics for individuals remaining at risk of coronavirus disease 2019(COVID-19).Neutralizing monoclonal antibody(mAb)that binds to theconserved S2 subunit of the SARS-CoV-2 spike(S)protein alone,or in combination with mAb that binds to the receptor-binding domain(RBD)of S protein,might be effective in eliciting protection from infection by a variety of SARS-CoV2 variants.Using high-throughput single-cell immunoglobulin sequencing of B cells from COVID-19-convalescent donors,we identified a high-affinity S2-specific mAb-39,that could inhibit original SARS-CoV-2 strain,Omicron BA.1,BA.2.86,BA.4,BA.5,and EG.5.1 S protein-mediated membrane fusion,leading to the neutralization of these pseudoviralinfections.Moreover,mAb-39 could also improve the neutralizing activity of anti-RBD antibody against the highlyneutralization-resistant Omicron variants.Molecular docking and point mutation analyses revealed that mAb-39 recognized epitopes within the conserved upstream region of the heptad repeat 2(HR2)motif of the S2 subunit.Collectively,these findings demonstrate that targeting the conserved upstream region of the HR2 motif(e.g.,using mAbs)provides anovel strategy for preventing the infection of SARS-CoV-2 and its variants. 展开更多
关键词 coronavirus disease 2019(COVID-19) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variants monoclonal antibody upstream region of heptad repeat 2(HR2) immunoglobulin repertoiresequencing
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The function and clinical application of extracellular vesicles in innate immune regulation 被引量:10
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作者 Xiaoxue Zhou Feng Xie +4 位作者 Lin Wang Long Zhang Suping Zhang Meiyu Fang Fangfang Zhou 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2020年第4期323-334,共12页
The innate immune system plays a crucial role in the host defense against viral and microbial infection.Exosomes constitute a subset of extracellular vesicles(EVs)that can be released by almost all cell types.Owing to... The innate immune system plays a crucial role in the host defense against viral and microbial infection.Exosomes constitute a subset of extracellular vesicles(EVs)that can be released by almost all cell types.Owing to their capacity to shield the payload from degradation and to evade recognition and subsequent removal by the immune system,exosomes efficiently transport functional components to recipient cells.Accumulating evidence has recently shown that exosomes derived from tumor cells,host cells and even bacteria and parasites mediate the communication between the invader and innate immune cells and thus play an irreplaceable function in the dissemination of pathogens and donor cell-derived molecules,modulating the innate immune responses of the host.In this review,we describe the current understanding of EVs(mainly focusing on exosomes)and summarize and discuss their crucial roles in determining innate immune responses.Additionally,we discuss the potential of using exosomes as biomarkers and cancer vaccines in diagnostic and therapeutic applications. 展开更多
关键词 extracellular vesicles EXOSOME innate immune cancer diagnosis IMMUNOTHERAPY
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HDAC6 inhibitor loaded bimetallene nanosheets with antagonizing thermoresistance for augmented mild photothermal therapy
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作者 Lingyu Qiu Shan Lei +5 位作者 Jing Zhang Ruhan Yan Wansi Chen Jing Lin Wei-Guo Zhu Peng Huang 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第9期235-242,共8页
Photothermal therapy(PTT)induces thermoresistance through cellular heat shock response,which impairs the therapeutic efficacy of the PTT.To resolve this problem,we developed a photothermal theranostics(denoted as PMH)... Photothermal therapy(PTT)induces thermoresistance through cellular heat shock response,which impairs the therapeutic efficacy of the PTT.To resolve this problem,we developed a photothermal theranostics(denoted as PMH),which integrated the photothermal conversion agent of PdMo bimetallene with histone deacetylase 6(HDAC6)selected inhibitor(ACY-1215),showing the synergistic antitumor effect both in vitro and in vivo.Mechanistically,under the photoacoustic imaging(PA)navigation,the released ACY-1215 triggered by NIR laser irradiation decrease the heat shock proteins(HSPs)expression and weaken the HDAC6-regulated HSP90 deacetylation,thus hindering the degradation of PTT-induced misfolded or unfold proteins through proteasome dependent pathway.Moreover,mild photothermal therapy(mPTT)treatment compromised the autophagy,which induced by HDAC6 inhibition,leading to mPTTinduced misfolded or unfold proteins further accumulation.Given that inhibition of HDAC6 plus m PTT contribute to tumor eradication.This study develops a promising combination strategy based on m PTT for future cancer treatment. 展开更多
关键词 Mild photothermal therapy THERMORESISTANCE Histone deacetylase 6 Heat shock proteins AUTOPHAGY
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Investigation on Concentrated Ⅴ(Ⅳ)/Ⅴ(Ⅴ) Redox Reaction by Rotating Disc Voltammetry
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作者 文越华 张华民 +3 位作者 钱鹏 马海鹏 衣宝廉 杨裕生 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2007年第3期278-283,共6页
The kinetic characteristics of the concentrated Ⅴ(Ⅳ)/Ⅴ(Ⅴ) couple have been studied at a glassy carbon electrode in sulfuric acid using rotating-disc electrode and cyclic voltammetry. The kinetics of the Ⅴ(Ⅳ... The kinetic characteristics of the concentrated Ⅴ(Ⅳ)/Ⅴ(Ⅴ) couple have been studied at a glassy carbon electrode in sulfuric acid using rotating-disc electrode and cyclic voltammetry. The kinetics of the Ⅴ(Ⅳ)/Ⅴ(Ⅴ) redox couple reaction was found to be electrochemically quasi-reversible with the slower kinetics for the Ⅴ(Ⅴ) reduction than that for the Ⅴ(Ⅳ) oxidation. And, dependence of diffusion coefficients and kinetic parameters of Ⅴ(Ⅳ) species on the Ⅴ(Ⅳ) and H2SO4 concentration was investigated. It is shown that the concentration of active species Ⅴ(Ⅳ) should be over 1 mol·L^-1 for the redox flow battery application. Further, with increasing the Ⅴ(Ⅳ) and H2SO4 concentration, the diffusion coefficients of Ⅴ(Ⅳ) were gradually reduced whereas its kinetics was improved considerably, especially in the case of Ⅴ(Ⅳ) and H2SO4 up to 2 and 4 mol·L^-1. 展开更多
关键词 vanadium redox flow battery Ⅴ(Ⅳ)/Ⅴ(Ⅴ) couple high concentration rotating-disc electrode PARAMETER
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