Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated nowadays.Recent studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppressi...Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated nowadays.Recent studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppression of migration in lung cancer cells (1,2)Focusing on metastatic process, the ability of cancer cells to grow in an anchorage-independent condition determines the success of cancer metastasis [3].展开更多
Lung cancer has been one of the most fundamental leading causes of death within the past 10 years[1].The severity of the disease is related to the metastatic potential and aberrant apoptosis of lung cancer cells.Metas...Lung cancer has been one of the most fundamental leading causes of death within the past 10 years[1].The severity of the disease is related to the metastatic potential and aberrant apoptosis of lung cancer cells.Metastasis is the process when cancer cells transport from their original tumor site and establish a secondary tumor elsewhere.These aggressive behaviors comprise their anoikis resistance and their migrate abilities[2].The process of a programmed cell death in an attached condition is called apoptosis whereas anoikis is a cellular mortality in a detached condition.展开更多
Lung cancer patients have high mortality rate due to the high incidence rate of metastasis. To achieve metastasize, cancer cells require an ability to migrate from initial to secondary site. Therefore, the promising c...Lung cancer patients have high mortality rate due to the high incidence rate of metastasis. To achieve metastasize, cancer cells require an ability to migrate from initial to secondary site. Therefore, the promising compound with antimigrating effect might be a benefit for cancer metastasis (1)Dendroflorin, a potential active polyphenol compound, is extracted from Dendrobium brymerianum found in Thailand, Burma, Laos, and China.展开更多
The cancer microenvironment has been reported to have a significant impact on cancer cells in many ways.Indeed,in such an active environment,cell signaling molecules as well as mediators including proinflammatory cyto...The cancer microenvironment has been reported to have a significant impact on cancer cells in many ways.Indeed,in such an active environment,cell signaling molecules as well as mediators including proinflammatory cytokines and reactive species are found to be intensified.Among them,the concentrations of nitric oxide(NO),a reactive nitrogen species synthesized by many cells,such as endothelial,immune,and tumor cells,are found to be dramatically increased in lung cancer environments[1].Additionally,clinical observation has shown that NO levels in the lungs of lung cancer patients were increased in comparison to those of normal subjects[2].Together,these studies strongly support the role of NO in tumorigenesis and metastasis,although the underlying mechanisms remain obscure.展开更多
文摘Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated nowadays.Recent studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppression of migration in lung cancer cells (1,2)Focusing on metastatic process, the ability of cancer cells to grow in an anchorage-independent condition determines the success of cancer metastasis [3].
文摘Lung cancer has been one of the most fundamental leading causes of death within the past 10 years[1].The severity of the disease is related to the metastatic potential and aberrant apoptosis of lung cancer cells.Metastasis is the process when cancer cells transport from their original tumor site and establish a secondary tumor elsewhere.These aggressive behaviors comprise their anoikis resistance and their migrate abilities[2].The process of a programmed cell death in an attached condition is called apoptosis whereas anoikis is a cellular mortality in a detached condition.
文摘Lung cancer patients have high mortality rate due to the high incidence rate of metastasis. To achieve metastasize, cancer cells require an ability to migrate from initial to secondary site. Therefore, the promising compound with antimigrating effect might be a benefit for cancer metastasis (1)Dendroflorin, a potential active polyphenol compound, is extracted from Dendrobium brymerianum found in Thailand, Burma, Laos, and China.
文摘The cancer microenvironment has been reported to have a significant impact on cancer cells in many ways.Indeed,in such an active environment,cell signaling molecules as well as mediators including proinflammatory cytokines and reactive species are found to be intensified.Among them,the concentrations of nitric oxide(NO),a reactive nitrogen species synthesized by many cells,such as endothelial,immune,and tumor cells,are found to be dramatically increased in lung cancer environments[1].Additionally,clinical observation has shown that NO levels in the lungs of lung cancer patients were increased in comparison to those of normal subjects[2].Together,these studies strongly support the role of NO in tumorigenesis and metastasis,although the underlying mechanisms remain obscure.
