Cell therapy has achieved tremendous success in regenerative medicine in the past several decades. However, challenges such as cell loss, death and immune-rejection after transplantation still persist. Bio- materials ...Cell therapy has achieved tremendous success in regenerative medicine in the past several decades. However, challenges such as cell loss, death and immune-rejection after transplantation still persist. Bio- materials have been designed as carriers to deliver cells to desirable region for local tissue regeneration; as barriers to protect transplanted cells from host immune attack; or as reactors to stimulate host cell recruitment, homing and differentiation. With the assistance of bio- materials, improvement in treatment efficiency has been demonstrated in numerous animal models of degener- ative diseases compared with routine free cell-based therapy. Emerging clinical applications of biomaterial assisted cell therapies further highlight their great pro- mise in regenerative therapy and even cure for complex diseases, which have been failed to realize by conven- tional therapeutic approaches.展开更多
文摘Cell therapy has achieved tremendous success in regenerative medicine in the past several decades. However, challenges such as cell loss, death and immune-rejection after transplantation still persist. Bio- materials have been designed as carriers to deliver cells to desirable region for local tissue regeneration; as barriers to protect transplanted cells from host immune attack; or as reactors to stimulate host cell recruitment, homing and differentiation. With the assistance of bio- materials, improvement in treatment efficiency has been demonstrated in numerous animal models of degener- ative diseases compared with routine free cell-based therapy. Emerging clinical applications of biomaterial assisted cell therapies further highlight their great pro- mise in regenerative therapy and even cure for complex diseases, which have been failed to realize by conven- tional therapeutic approaches.
