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Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization
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作者 Shao-bin Wang Yosuke Nagasaka +4 位作者 Dionne Argyle Ayami Nagasaka Praveen Yerramothu Bradley DGelfand Jayakrishna Ambati 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第3期905-907,共3页
Dear Editor,Vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye ... Dear Editor,Vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye underlies many forms of aberrant ocular angiogenesis and resultant vision loss,including in neovascular age-related macular degeneration(nvAMD),proliferative diabetic retinopathy(PDR). 展开更多
关键词 DEGENERATION OCULAR RELEASE
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Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration 被引量:1
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作者 Siddharth Narendran Felipe Pereira +17 位作者 Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara Younghee Kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney Yosuke Nagasaka Shinichi Fukuda Kirstie L.Baker Kenneth M.Marion Jan M.Deussing Srinivas R.Sadda Bradley D.Gelfand Jayakrishna Ambati 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第5期1526-1534,共9页
Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global b... Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global blindness.We report that AβOs induce RPE degeneration,a clinical hallmark of geographic atrophy(GA),a vision-threatening late stage of AMD that is currently untreatable.We demonstrate that AβOs induce activation of the NLRP3 inflammasome in the mouse RPE in vivo and that RPE expression of the purinergic ATP receptor P2RX7,an upstream mediator of NLRP3 inflammasome activation,is required for AβO-induced RPE degeneration.Two classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors(NRTIs)and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced RPE degeneration.These findings crystallize the importance of P2RX7 and NLRP3 in a disease-relevant model of AMD and identify inflammasome inhibitors as potential treatments for GA. 展开更多
关键词 DEGENERATION ACTIVATION UPSTREAM
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