Host-microbe interactions at the gastrointestinal interface have emerged as a key component in the governance of human health and disease. Advances in micro-physiological systems are providing researchers with unprece...Host-microbe interactions at the gastrointestinal interface have emerged as a key component in the governance of human health and disease. Advances in micro-physiological systems are providing researchers with unprecedented access and insights into this complex relationship. These systems combine the benefits of microengineering, microfluidics, and cell culture in a bid to recreate the environmental con- ditions prevalent in the human gut. Here we present the human-microbial cross talk （HuMiX） platform, one such system that leverages this multidisciplinary approach to provide a representative in vitro model of the human gastrointestinal interface. HuMiX presents a novel and robust means to study the molecular interactions at the host-microbe interface. We summarize our proof-of-concept results obtained using the platform and highlight its potential to greatly enhance our understanding of host-microbe interactions with a potential to greatly impact the pharmaceutical, food, nutrition, and healthcare industries in the future. A number of key questions and challenges facing these technologies are also discussed.展开更多
基金supported by a proof-of-concept grant (PoC/15/11014639) to Paul Wilmes and Joelle V.Fritz through the CORE programme (CORE/14/ BM/8066232)supported by an ATTRACT programme grant (ATTRACT/A09/03)+5 种基金a CORE programme grant (CORE/11/BM/1186762)a European Union Joint Programming in Neurodegenerative Diseases grant (INTER/JPND/12/01)a proof-of-concept grant (PoC15/11014639)an Accompany Measures mobility grant (12/AM2c/05)an Aide à la Formation Recherché (AFR) postdoctoral grant (AFR/PDR 2013-1/BM/5821107)funded by the Luxembourg National Research Fund (FNR)
文摘Host-microbe interactions at the gastrointestinal interface have emerged as a key component in the governance of human health and disease. Advances in micro-physiological systems are providing researchers with unprecedented access and insights into this complex relationship. These systems combine the benefits of microengineering, microfluidics, and cell culture in a bid to recreate the environmental con- ditions prevalent in the human gut. Here we present the human-microbial cross talk （HuMiX） platform, one such system that leverages this multidisciplinary approach to provide a representative in vitro model of the human gastrointestinal interface. HuMiX presents a novel and robust means to study the molecular interactions at the host-microbe interface. We summarize our proof-of-concept results obtained using the platform and highlight its potential to greatly enhance our understanding of host-microbe interactions with a potential to greatly impact the pharmaceutical, food, nutrition, and healthcare industries in the future. A number of key questions and challenges facing these technologies are also discussed.
