To the Editor:Alcohol-induced heart defect is one of the most important clinical manifestations of fetal alcohol spectrum disorder(FASD),characterized by atrioventricular septal defect and arterial conical deformity.[...To the Editor:Alcohol-induced heart defect is one of the most important clinical manifestations of fetal alcohol spectrum disorder(FASD),characterized by atrioventricular septal defect and arterial conical deformity.[1]Resveratrol,a polyphenol component of the traditional Chinese herb Polygonum cuspidatum,which is mainly extracted from its rhizome,is known to exhibit beneficial effects on the cardiovascular system.For example,resveratrol has beneficial effects on heart dysfunction,myocardial hypertrophy,and pressure overload.Moreover,resveratrol was found to inhibit platelet aggregation,prevent atherosclerosis,and scavenge free radicals.[2]However,the effect of resveratrol on alcohol-induced heart defect during heart formation is still unknown.The unique characteristics of zebrafish embryos,such as their transparent body,in vitro fertilization,and short reproductive cycle,make them an attractive tool for cardiovascular research.Moreover,the immersion-based alcohol delivery method used with zebrafish embryos is non-invasive unlike most of the alcohol administration protocols applied in rodent models.展开更多
基金the National Natural Science Foundations of China(No.81771632)the National Key Research and Development Program(No.2016YFC1000500)the Shanghai Key Laboratory of Birth Defect(No.13DZ2260600).
文摘To the Editor:Alcohol-induced heart defect is one of the most important clinical manifestations of fetal alcohol spectrum disorder(FASD),characterized by atrioventricular septal defect and arterial conical deformity.[1]Resveratrol,a polyphenol component of the traditional Chinese herb Polygonum cuspidatum,which is mainly extracted from its rhizome,is known to exhibit beneficial effects on the cardiovascular system.For example,resveratrol has beneficial effects on heart dysfunction,myocardial hypertrophy,and pressure overload.Moreover,resveratrol was found to inhibit platelet aggregation,prevent atherosclerosis,and scavenge free radicals.[2]However,the effect of resveratrol on alcohol-induced heart defect during heart formation is still unknown.The unique characteristics of zebrafish embryos,such as their transparent body,in vitro fertilization,and short reproductive cycle,make them an attractive tool for cardiovascular research.Moreover,the immersion-based alcohol delivery method used with zebrafish embryos is non-invasive unlike most of the alcohol administration protocols applied in rodent models.
