Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain f...Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain functions can be modified by exogenous brain neuromodulation techniques that deliver physical energy(e.g.,electrical current or magnetic pulses)into the brain[1],such as deep brain stimulation,transcranial magnetic stimulation,and tran-scranial direct current stimulation.展开更多
Chronic wounds affect around 2% of the world population with an annual multi-billion dollar cost to the healthcare system. This background pushes the development of new therapies and procedures for wound healing and i...Chronic wounds affect around 2% of the world population with an annual multi-billion dollar cost to the healthcare system. This background pushes the development of new therapies and procedures for wound healing and its assessment. Among them, the potential of hydrogen(pH) assessment is an important indicator of the wound healing stage and condition. This paper presents the development of the first optical fiber-embedded smart wound dressing for pH assessment. An intrinsically pH-sensitive optical fiber is fabricated using a polydimethylsiloxane(PDMS) precursor doped with rhodamine B dye. Raman and Fourier transform infrared(FTIR) spectroscopies are performed in order to verify the presence of rhodamine B and PDMS in the fiber samples. Then, the fiber is embedded in gauze fabric and hydrocolloid wound dressing. In addition, such low Young’s modulus of PDMS fiber enables its use as a highly sensitive pressure sensor, where the results show that the fiber-embedded bandage can measure pressures as low as 0.1 kPa with a high linearity in the range of 0 to 0.3 kPa. The smart bandage is subjected to different pH, which resulted in a wavelength shift of 0.67 nm/pH when the absorption peak at 515 nm was analyzed. Furthermore, pH increase leads to linear decrease of the transmitted optical power(R2 of 0.998), with rise and fall times below 20 s and 30 s, respectively. Therefore, the proposed optical fiber-embedded smart bandage enables the simultaneous assessment of pressure and pH on the wound region.展开更多
基金the National Natural Science Foundation of China(82071999,61431002,31521063,and 61273287)the National 973 Program(2014CB846100).
文摘Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain functions can be modified by exogenous brain neuromodulation techniques that deliver physical energy(e.g.,electrical current or magnetic pulses)into the brain[1],such as deep brain stimulation,transcranial magnetic stimulation,and tran-scranial direct current stimulation.
基金National Natural Science Foundation of China (62003046)Funda??o para a Ciência e a Tecnologia(CEECIND/00034/2018, UIDB/50025/2020, UIDP/50025/2020)+2 种基金Petrobras (2017/00702-6)Conselho Nacional de Desenvolvimento Científico e Tecnológico (304049/2019-0, 427054/2018-4)Funda??o Estadual de AmparoàPesquisa do Estado do Espírito Santo (2020-F057G,84336650)。
文摘Chronic wounds affect around 2% of the world population with an annual multi-billion dollar cost to the healthcare system. This background pushes the development of new therapies and procedures for wound healing and its assessment. Among them, the potential of hydrogen(pH) assessment is an important indicator of the wound healing stage and condition. This paper presents the development of the first optical fiber-embedded smart wound dressing for pH assessment. An intrinsically pH-sensitive optical fiber is fabricated using a polydimethylsiloxane(PDMS) precursor doped with rhodamine B dye. Raman and Fourier transform infrared(FTIR) spectroscopies are performed in order to verify the presence of rhodamine B and PDMS in the fiber samples. Then, the fiber is embedded in gauze fabric and hydrocolloid wound dressing. In addition, such low Young’s modulus of PDMS fiber enables its use as a highly sensitive pressure sensor, where the results show that the fiber-embedded bandage can measure pressures as low as 0.1 kPa with a high linearity in the range of 0 to 0.3 kPa. The smart bandage is subjected to different pH, which resulted in a wavelength shift of 0.67 nm/pH when the absorption peak at 515 nm was analyzed. Furthermore, pH increase leads to linear decrease of the transmitted optical power(R2 of 0.998), with rise and fall times below 20 s and 30 s, respectively. Therefore, the proposed optical fiber-embedded smart bandage enables the simultaneous assessment of pressure and pH on the wound region.
