About 10%-15% of patients with gastroesophageal reflux disease develop Barrett’s esophagus. This is considered a premalignant condition because it can progress from metaplasia to high-grade dysplasia, and eventually ...About 10%-15% of patients with gastroesophageal reflux disease develop Barrett’s esophagus. This is considered a premalignant condition because it can progress from metaplasia to high-grade dysplasia, and eventually to adenocarcinoma. Recently, major advances have been made in the endoscopic treatment of Barrett’s esophagus, therefore limiting the role of surgery in the treatment of this disease.展开更多
Pancreatic cancer is a highly lethal malignancy with poor overall survival due to silent progression until primary tumor growth or metastatic dissemination develops clinical symptoms.Even in the minority of patients w...Pancreatic cancer is a highly lethal malignancy with poor overall survival due to silent progression until primary tumor growth or metastatic dissemination develops clinical symptoms.Even in the minority of patients with early diagnosis and candidacy for curative intent surgery,postoperative recurrence after surgical resection is very frequent.Due to these findings,efforts to identify minimally invasive ways to provide earlier diagnosis and enhanced prognostication are increasingly warranted.Liquid biopsies assessing for tumor derived materials shed into the blood are a promising tool to accomplish this goal;however,in pancreatic cancer,peripheral blood analyses remain dependent on the degree of tumor burden with a prohibitively low yield until the cancer is widely metastatic.To overcome this limitation,increasing literature has emerged evaluating the possibility of portal venous blood as a new,potentially higher yield liquid biopsy target in pancreatic cancer.This review will discuss the current literature and clinical application potential of mesenteric vasculature,or portal venous blood,as liquid biopsies in the diagnosis,prognosis and management of patients with pancreatic cancer.展开更多
文摘About 10%-15% of patients with gastroesophageal reflux disease develop Barrett’s esophagus. This is considered a premalignant condition because it can progress from metaplasia to high-grade dysplasia, and eventually to adenocarcinoma. Recently, major advances have been made in the endoscopic treatment of Barrett’s esophagus, therefore limiting the role of surgery in the treatment of this disease.
文摘Pancreatic cancer is a highly lethal malignancy with poor overall survival due to silent progression until primary tumor growth or metastatic dissemination develops clinical symptoms.Even in the minority of patients with early diagnosis and candidacy for curative intent surgery,postoperative recurrence after surgical resection is very frequent.Due to these findings,efforts to identify minimally invasive ways to provide earlier diagnosis and enhanced prognostication are increasingly warranted.Liquid biopsies assessing for tumor derived materials shed into the blood are a promising tool to accomplish this goal;however,in pancreatic cancer,peripheral blood analyses remain dependent on the degree of tumor burden with a prohibitively low yield until the cancer is widely metastatic.To overcome this limitation,increasing literature has emerged evaluating the possibility of portal venous blood as a new,potentially higher yield liquid biopsy target in pancreatic cancer.This review will discuss the current literature and clinical application potential of mesenteric vasculature,or portal venous blood,as liquid biopsies in the diagnosis,prognosis and management of patients with pancreatic cancer.
