Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide associati...Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide association study to identify the genetic factors responsible for developing critical COVID-19.632 critical patients with COVID-19 and 3021 healthy controls from the Chinese population were recruited.First,we identified a genome-wide significant difference of IL-6 rs2069837(p=9.73×10^(−15),OR=0.41)between 437 critical patients with COVID-19 and 2551 normal controls in the discovery cohort.展开更多
基金We thank all the patients and their families for participating in this study.This research project was supported by the National Precision Medicine Project(2016YFC0905200)the National Natural Science Foundation of China(81790643,81970839,81871722,82121003 and 82072373)+2 种基金the Sichuan Science and Technology Program(2020YFS0014,2020YFS0558,2020ZYD035,2020ZYD037,2021ZYD0082,2019JDJQ0031,2021YFS0369,2021JDGD0036,2021YFS0033,2021YFS0404,2021YFS0388,2022JDTD0024 and 2020JDTD0028)the Grant from Chinese Academy of Medical Sciences(No.2019-I2M5-032)Sichuan Provincial Health Commission(20ZDCX002).
文摘Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide association study to identify the genetic factors responsible for developing critical COVID-19.632 critical patients with COVID-19 and 3021 healthy controls from the Chinese population were recruited.First,we identified a genome-wide significant difference of IL-6 rs2069837(p=9.73×10^(−15),OR=0.41)between 437 critical patients with COVID-19 and 2551 normal controls in the discovery cohort.
