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Targeting of Androgen Receptor Expression by Andro-miRs as Novel Adjunctive Therapeutics in Prostate Cancer
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作者 Jey Sabith Ebron Crystal M. Weyman Girish C. Shukla 《Journal of Cancer Therapy》 2013年第4期47-58,共12页
Prostate cancer begins as an androgen-responsive disease. However, subsequent accumulation of multiple sequential genetic and epigenetic alterations transforms the disease into an aggressive, castration-resistant pros... Prostate cancer begins as an androgen-responsive disease. However, subsequent accumulation of multiple sequential genetic and epigenetic alterations transforms the disease into an aggressive, castration-resistant prostate cancer (CRPC). The monoallelic Androgen Receptor (AR) is associated with the onset, growth and development of Prostate cancer. The AR is a ligand-dependent transcription factor, and the targeting of androgen- and AR-signaling axis remains the primary therapeutic option for Prostate cancer (PCa) treatment. A durable and functional disruption of AR signaling pathways combining both traditional and novel therapeutics is likely to provide better treatment options for CRPC. Recent work has indicated that expression of AR is modulated at the posttranscriptional level by regulatory miRNAs. Due to a relatively long 3’ untranslated region (UTR) of AR mRNA, the posttranscription expression is likely to be regulated by hundreds of miRNAs in normal as well as in disease state. The main objective of the article is to offer a thought-provoking concept of “andro-miRs” and their potential application in AR gene expression targeting. This new paradigm for targeting constitutively active AR and its tumor specific splicing isoforms using andro-miRs may pave the way for a novel adjunctive therapy and improved treatment of CRPC. 展开更多
关键词 Androgen Receptor microRNA 3’ Untranslated Region PROSTATE CANCER CASTRATION-RESISTANT PROSTATE CANCER (CRPC) Andro-miR
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L13a-dependent translational control in macrophages imits the pathogenesis of colitis 被引量:1
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作者 Darshana Poddar Ravinder Kaur +1 位作者 William M Baldwin III Barsanjit Mazumder 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2016年第6期816-827,共12页
Sustained inflammation from infiltrated immune cells plays a pivotal role in the pathogenesis of ulcerative colitis (UC). Previously, we established the role of ribosomal protein L13a in the regulation of an inflamm... Sustained inflammation from infiltrated immune cells plays a pivotal role in the pathogenesis of ulcerative colitis (UC). Previously, we established the role of ribosomal protein L13a in the regulation of an inflammation-responsive post-transcriptional operon in myeloid cells. However, the role of this protein as a molecular cue to control the severity of colitis is not known. Here, we examined whether L13a-dependent translational control in macrophages could serve as an endogenous defense against colitis. The administration of dextran sodium sulfate induced experimental colitis in myeloid-specific L13a-knockout (KO) and control mice. Pathological scoring and injury to the colon mucosa evaluated the severity of colitis. The steady-state levels of several pro-inflammatory cytokines and chemokines were determined through ELISA and polyribosome profile analysis. Rapid weight loss, severe rectal bleeding, shortening of the colon, and significantly reduced survival rate were observed in the KO mice. Histopathological analysis of the colons of KO mice showed a severe disruption of epithelial crypts with immune cell infiltrates. Elevated levels of several inflammatory cytokines and chemokines and abrogation of their naturally imposed translational silencing were observed in the colons of the KO mice. Higher serum levels of several pro-inflammatory cytokines and the release of gut bacteria and endotoxins into the blood streams of KO mice were detected, suggesting the amplification of the inflammatory response to septicemia. Taken together, these results reveal an essential role for L13a in the endogenous protection against UC and demonstrate the potential for new therapeutic opportunities through the deliberate promotion of this mechanism. 展开更多
关键词 INFLAMMATION L13a macrophages translational control ulcerative colitis
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GAITing the GUT
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作者 Barsanjit Mazumder 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2018年第12期1082-1084,共3页
The gastrointestinal tract contains one of the most abundant populations of macrophages in the body.1 These cells play a critical role in the maintenance of gut homeostasis and defend the integrity of epithelial crypt... The gastrointestinal tract contains one of the most abundant populations of macrophages in the body.1 These cells play a critical role in the maintenance of gut homeostasis and defend the integrity of epithelial crypts and the mucosal membrane.Chronic disruption of gut homeostasis can cause sustained inflammation mediated by intestinal macrophages.Since inflammation plays a key role in ulcerative colitis(UC)and other forms of inflammatory bowel disease(IBD),2–4 an improved understanding of how inflammation is regulated in the gut is essential for the development of effective therapies for such diseases. 展开更多
关键词 INFLAMMATION HOMEOSTASIS SUSTAINED
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