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不同符号形式数字的数量表征 被引量:3
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作者 赵晖 张红川 +3 位作者 周新林 郭易 赵丽波 董奇 《心理科学》 CSSCI CSCD 北大核心 2008年第3期524-527,545,共5页
针对以往对不同符号形式数字数量表征的ERP研究只应用以反应为原点分段平均分析方法,以及忽略对后期符号效应观察,从而造成对数量表征的考察不完善的状况,本研究利用ERP技术,结合借助潜伏期平移思想的以刺激为原点的分段平均方法,对阿... 针对以往对不同符号形式数字数量表征的ERP研究只应用以反应为原点分段平均分析方法,以及忽略对后期符号效应观察,从而造成对数量表征的考察不完善的状况,本研究利用ERP技术,结合借助潜伏期平移思想的以刺激为原点的分段平均方法,对阿拉伯与汉字小写的两位数数字的数量大小比较任务进行考察。结果表明阿拉伯数字与汉字数字在编码表征阶段存在差异,ERP结果中符号效应与距离效应无交互作用,但是在距离效应出现的同时仍然存在符号效应,说明不同符号形式数字的数量表征并非完全相同。 展开更多
关键词 数字大小比较 符号效应 距离效应 数量表征 事件相关电位
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Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery 被引量:2
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作者 Tarik Zahr Vijay K.Boda +5 位作者 Jian Ge Lexiang Yu Zhongzhi Wu Jianwen Que Wei Li Li Qiang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第5期2137-2152,共16页
Estrogen is imperative to mammalian reproductivity,metabolism,and aging.However,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain... Estrogen is imperative to mammalian reproductivity,metabolism,and aging.However,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain malignancies.In contrast,ERβis more broadly expressed in metabolic tissues and the skin.Thus,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERαactivation.Here,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or genistein.Treatment of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in vitro.We further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound healing.Therefore,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health. 展开更多
关键词 Estrogen receptorβ Aging METABOLISM Skin injury Muscle metabolism Small molecule conjugates Regeneration ADIPOSITY
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KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2 被引量:3
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作者 Shao-Hua Wang Jing Hao +7 位作者 Chao Zhang Fei-Fei Duan Ya-Tzu Chiu Ming Shi Xin Huang Jihong Yang Huiqing Cao Yangming Wang 《Science China(Life Sciences)》 SCIE CAS CSCD 2022年第10期1985-1997,共13页
The pluripotent state of embryonic stem cells(ESCs)is regulated by a sophisticated network of transcription factors.High expression of KLF17 has recently been identified as a hallmark of naive state of human ESCs(h ES... The pluripotent state of embryonic stem cells(ESCs)is regulated by a sophisticated network of transcription factors.High expression of KLF17 has recently been identified as a hallmark of naive state of human ESCs(h ESCs).However,the functional role of KLF17 in naive state is not clear.Here,by employing various gain and loss-of-function approaches,we demonstrate that KLF17 is essential for the maintenance of naive state and promotes the primed to naive state transition in h ESCs.Mechanistically,we identify MAPK3 and ZIC2 as two direct targets repressed by KLF17.Overexpression of MAPK3 or ZIC2 partially blocks KLF17 from promoting the naive pluripotency.Furthermore,we find that human and mouse homologs of KLF17 retain conserved functions in promoting naive pluripotency of both species.Finally,we show that Klf17 may be essential for early embryo development in mouse.These findings demonstrate the important and conserved function of KLF17 in promoting naive pluripotency and reveal two essential transcriptional targets of KLF17 that underlie its function. 展开更多
关键词 KLF17 human embryonic stem cell naive pluripotency primed to naive state transition ZIC2
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Zfp281 is essential for epiblast maturation through a cell autonomous effect
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作者 Ruge Zang Xin Huang +3 位作者 Dan Li Hongwei Zhou Shaorong Gao Jianlong Wang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2022年第1期85-88,共4页
Pluripotency is recognized as a spectrum of cellular states spanning the na?ve pluripotency established in the preimplantation blastocyst and its transition into primed pluripotency in the postimplantation epiblast ce... Pluripotency is recognized as a spectrum of cellular states spanning the na?ve pluripotency established in the preimplantation blastocyst and its transition into primed pluripotency in the postimplantation epiblast cells. The exit from pluripotency is followed by the initiation of gastrulation(Brennan et al., 2001;Nichols and Smith, 2009). 展开更多
关键词 IMPLANTATION AUTONOMOUS EFFECT
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Transformati on al leadership and employee voice: an affective perspective
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作者 Zhen Wang Shiyong Xu +1 位作者 Yanling Sun Yanjun Liu 《Frontiers of Business Research in China》 2019年第1期19-32,共14页
This study aims to examine the effect of transformational leadership on employee voice behavior. Specifically, this study investigates the mediating role of positive affect in linking sformational leadership with voic... This study aims to examine the effect of transformational leadership on employee voice behavior. Specifically, this study investigates the mediating role of positive affect in linking sformational leadership with voice and the moderating role of over-qualification in influencing the mediation of positive affect. In particular, a twowave survey was con ducted. A sample of 271 participa nts complete a questionnaire measuring tran sformati on al leadership, positive affect and various demographic variables in the first wave. Then, they complete a second questionnaire measuring perceived over-qualification and voice behavior 2 weeks later. We conduct a series of multiple regression analyses to test the model. The results show that positive affect partially mediated the relationship between transformational leadership and employee voice behavior. Over-qualification moderated the relationship between positive affect and voice. In addition, moderated mediation analyses reveal that positive affect mediates the relationship between transformational leadership and voice only for highly over-qualified employees. This study investigates a new method linking transformational leadership and voice from an affective perspective by finding the mediating effect of positive affect. We also verify the role of "energized to" process in shaping proactive behaviors. Finally, this study examines the boundary conditions of the effect of positive affect on voice. 展开更多
关键词 EMPLOYEE SELF-EFFICACY Transformational LEADERSHIP Voice Positive affect PERCEIVED over-qualification PROACTIVE behaviors
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ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency
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作者 Xin Huang Nazym Bashkenova +2 位作者 Jihong Yang Dan Li Jianlong Wang 《Protein & Cell》 SCIE CAS CSCD 2021年第3期213-219,共7页
Dear Editor,Cell-fate decisions are governed by comprehensive generegulatory programs.During the preimplantation development,at least two waves of cell fate decisions are made while the cells gradually lose their toti... Dear Editor,Cell-fate decisions are governed by comprehensive generegulatory programs.During the preimplantation development,at least two waves of cell fate decisions are made while the cells gradually lose their totipotency(Schrode et al.,2013).The first decision involves the spatial separation of outer-residing trophectoderm(TE)cells from inner cell mass(ICM)in E3.5 mouse blastocyst.The second decision involves gene expression refinements and active cell sorting within the ICM that ultimately results in epiblast(EPI)cells,residing deep within the ICM,and the primitive endoderm(PrE)cells comprising a monolayer of blastocoel-facing cells at the surface of the ICM(Schrode et al.,2013).OCT4,SOX2,and NANOG are master transcription factors(TFs)essential for the formation and maintenance of the pluripotent ICM cells and their in vitro counterparts mouse embryonic stem cells(ESCs).On the other hand,GATA4,GATA6,and SOX17 are master TFs of the PrE cells and their in vitro counterparts extraembryonic endoderm stem cells(XENs). 展开更多
关键词 restrict implantation SORTING
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Correction to: ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency
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作者 Xin Huang Nazym Bashkenova +2 位作者 Jihong Yang Dan Li Jianlong Wang 《Protein & Cell》 SCIE CSCD 2021年第6期511-513,共3页
CORRECTION TO:PROTEIN CELL HTTPS://DOI.ORG/10.1007/S13238-020-00775-X In the original publication the labelling in middle and bottom panels of Fig.2K is published incorrectly as“Soc17”.The correct labeling is availa... CORRECTION TO:PROTEIN CELL HTTPS://DOI.ORG/10.1007/S13238-020-00775-X In the original publication the labelling in middle and bottom panels of Fig.2K is published incorrectly as“Soc17”.The correct labeling is available in this correction as“Sox17”. 展开更多
关键词 CORRECTION restrict POTENTIAL
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