Objective The associations of physical multimorbidity with depressive symptoms have been investigated in a number of studies.However,whether patterns of chronic physical conditions have comparatively different associa...Objective The associations of physical multimorbidity with depressive symptoms have been investigated in a number of studies.However,whether patterns of chronic physical conditions have comparatively different associations with depressive symptoms remains unclear.This study aimed to investigate the associations of physical multimorbidity patterns with depressive symptoms.Design This study was designed as a nationwide cross-sectional survey in Japan.setting General sample of the Japanese population.Participants Adult Japanese residents were selected by a quota sampling method.Data were analysed from 1788 residents who reported one or more chronic health conditions.results Among four physical multimorbidity patterns:cardiovascular-renal metabolic(CRM),skeletal-articular digestive(SAD),respiratory-dermal(RDE)and malignant-digestive urologic(MDU),multivariable logistic regression analyses revealed that the RDE pattern showed the strongest association with depressive symptoms(aOR=1.68,95%CI:1.21 to 2.31 for the pattern score highest quartile,compared with the lowest quartile),followed by SAD and MDU patterns(aOR=1.41,95%CI:1.01 to 1.98 for the SAD pattern score highest quartile;1.41,95%CI:1.01 to 1.96 for the MDU pattern score highest quartile,compared with the lowest quartile).In contrast,the CRM pattern score was not significantly associated with depressive symptoms(aOR=1.31,95%CI:0.90 to 1.89 for the pattern score highest quartile,compared with the lowest quartile).Conclusions Physical multimorbidity patterns have different associations with depressive symptoms.Among these patterns,patients with the RDE pattern may be at a higher risk for developing depressive symptoms.This study reinforces the evidence that cluster pattern of chronic health conditions is a useful measure for clinical management of multimorbidity as it is differently associated with mental health status,which is one of the crucial outcomes for multimorbid patients.展开更多
基金the Institute for Health Outcomes and Process Evaluation Research(iHope International)provided the ethical approval for this study(approval no 201611).
文摘Objective The associations of physical multimorbidity with depressive symptoms have been investigated in a number of studies.However,whether patterns of chronic physical conditions have comparatively different associations with depressive symptoms remains unclear.This study aimed to investigate the associations of physical multimorbidity patterns with depressive symptoms.Design This study was designed as a nationwide cross-sectional survey in Japan.setting General sample of the Japanese population.Participants Adult Japanese residents were selected by a quota sampling method.Data were analysed from 1788 residents who reported one or more chronic health conditions.results Among four physical multimorbidity patterns:cardiovascular-renal metabolic(CRM),skeletal-articular digestive(SAD),respiratory-dermal(RDE)and malignant-digestive urologic(MDU),multivariable logistic regression analyses revealed that the RDE pattern showed the strongest association with depressive symptoms(aOR=1.68,95%CI:1.21 to 2.31 for the pattern score highest quartile,compared with the lowest quartile),followed by SAD and MDU patterns(aOR=1.41,95%CI:1.01 to 1.98 for the SAD pattern score highest quartile;1.41,95%CI:1.01 to 1.96 for the MDU pattern score highest quartile,compared with the lowest quartile).In contrast,the CRM pattern score was not significantly associated with depressive symptoms(aOR=1.31,95%CI:0.90 to 1.89 for the pattern score highest quartile,compared with the lowest quartile).Conclusions Physical multimorbidity patterns have different associations with depressive symptoms.Among these patterns,patients with the RDE pattern may be at a higher risk for developing depressive symptoms.This study reinforces the evidence that cluster pattern of chronic health conditions is a useful measure for clinical management of multimorbidity as it is differently associated with mental health status,which is one of the crucial outcomes for multimorbid patients.
