Dear Editor,Deep brain stimulation targeting the subthalamic nucleus(STN-DBS)can relieve motor symptoms in patients with advanced Parkinson's disease(PD).The efficacy of DBS is strongly dependent on stimulus frequ...Dear Editor,Deep brain stimulation targeting the subthalamic nucleus(STN-DBS)can relieve motor symptoms in patients with advanced Parkinson's disease(PD).The efficacy of DBS is strongly dependent on stimulus frequency,typically exceeding 100 Hz[1].However,the mechanism underlying this high-frequency dependence remains unelucidated.DBS likely acts via several,nonexclusive mechanisms,including local and network-wide electrical and neurochemical effects,modulation of oscillatory activity,synaptic plasticity,and potentially neuroprotection and neurogenesis.Nonetheless,none of these fully explains the high-frequency dependence and the rapid therapeutic action of DBS.展开更多
Dear Editor,Motor control as a function of the basal ganglia circuit is crucial for every aspect of life and movement disorders,such as Parkinson’s disease(PD).In PD,the progressive denervation of dopamine in the dor...Dear Editor,Motor control as a function of the basal ganglia circuit is crucial for every aspect of life and movement disorders,such as Parkinson’s disease(PD).In PD,the progressive denervation of dopamine in the dorsal striatum leads to inhibition of the direct pathway and facilitation of the indirect pathway and results in activation of the subthalamic nucleus(STN)and globus pallidus internus(GPi),two important nuclei in the motor loop of basal ganglia.展开更多
基金supported by the National Natural Science Foundation of China(82201619).
文摘Dear Editor,Deep brain stimulation targeting the subthalamic nucleus(STN-DBS)can relieve motor symptoms in patients with advanced Parkinson's disease(PD).The efficacy of DBS is strongly dependent on stimulus frequency,typically exceeding 100 Hz[1].However,the mechanism underlying this high-frequency dependence remains unelucidated.DBS likely acts via several,nonexclusive mechanisms,including local and network-wide electrical and neurochemical effects,modulation of oscillatory activity,synaptic plasticity,and potentially neuroprotection and neurogenesis.Nonetheless,none of these fully explains the high-frequency dependence and the rapid therapeutic action of DBS.
基金This work was supported by a grant from the National Natural Science Foundation of China (81830034).
文摘Dear Editor,Motor control as a function of the basal ganglia circuit is crucial for every aspect of life and movement disorders,such as Parkinson’s disease(PD).In PD,the progressive denervation of dopamine in the dorsal striatum leads to inhibition of the direct pathway and facilitation of the indirect pathway and results in activation of the subthalamic nucleus(STN)and globus pallidus internus(GPi),two important nuclei in the motor loop of basal ganglia.
