To date, the coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic and public health disaster. In addition to acute respiratory manifestations, patients with COVID-19 exhibit other non-respiratory ...To date, the coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic and public health disaster. In addition to acute respiratory manifestations, patients with COVID-19 exhibit other non-respiratory manifestations, particularly in those with severe underlying disease. Few specific therapeutics are effective for COVID-19, and supportive care is the primary remedy. Here, we comprehensively surveyed the most recent reports on extrapulmonary complications of COVID-19 and their corresponding treatments, as well as the comparison of different clinical symptoms and complications of COVID-19, severe acute respiratory syndrome (SARS), and the Middle East respiratory syndrome (MERS) patients. We wish to provide a molecular and cellular understanding of the complications of COVID-19 and provide guidance for future diagnostics, therapeutics, and prognostics of COVID-19.展开更多
We established a photoacoustic imaging(PAI)system that can provide variable gain at different depths.The PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an...We established a photoacoustic imaging(PAI)system that can provide variable gain at different depths.The PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an imaging-acquisition-and-processing unit with an ultrasound transducer.Avoltage-controlled attenuator was used to realize variable gain at different depths when acquiring PAI signals.The proof-of-concept imaging results for variable gain at different depths were achieved using specic phantoms.Both resolution and optical contrast obtained through the results of variable gain for a targeted depth range are better than those of constant gain for all depths.To further testify the function,we imaged the sagittal section of the body of in vivo nude mice.In addition,we imaged an absorption sample embedded in a chicken breast tissue,reaching a maximum imaging depth of4.6 cm.The results obtained using the proposed method showed better resolution and contrast than when using 50 dB gain for all depths.The depth range resolution was1 mm,and the maximum imaging depth of our system reached4.6 cm.Furthermore,blood vessels can be revealed and targeted depth range can be selected in nude mice imaging.展开更多
文摘To date, the coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic and public health disaster. In addition to acute respiratory manifestations, patients with COVID-19 exhibit other non-respiratory manifestations, particularly in those with severe underlying disease. Few specific therapeutics are effective for COVID-19, and supportive care is the primary remedy. Here, we comprehensively surveyed the most recent reports on extrapulmonary complications of COVID-19 and their corresponding treatments, as well as the comparison of different clinical symptoms and complications of COVID-19, severe acute respiratory syndrome (SARS), and the Middle East respiratory syndrome (MERS) patients. We wish to provide a molecular and cellular understanding of the complications of COVID-19 and provide guidance for future diagnostics, therapeutics, and prognostics of COVID-19.
基金the financial support fromNational Natural Science Foundation of China(NSFC)(61675113,61527808,81401539,and 31271056)Science and Technology Research Program of Shenzhen City(JSGG20150331151536448,JCYJ20160428182247170,and JCYJ20170412170255060)+1 种基金Shenzhen basic research layout project(JCYJ20160324163759208)the projects in Shenzhen Medical Engineering Laboratory For Human Auditory-equilibrium Function。
文摘We established a photoacoustic imaging(PAI)system that can provide variable gain at different depths.The PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an imaging-acquisition-and-processing unit with an ultrasound transducer.Avoltage-controlled attenuator was used to realize variable gain at different depths when acquiring PAI signals.The proof-of-concept imaging results for variable gain at different depths were achieved using specic phantoms.Both resolution and optical contrast obtained through the results of variable gain for a targeted depth range are better than those of constant gain for all depths.To further testify the function,we imaged the sagittal section of the body of in vivo nude mice.In addition,we imaged an absorption sample embedded in a chicken breast tissue,reaching a maximum imaging depth of4.6 cm.The results obtained using the proposed method showed better resolution and contrast than when using 50 dB gain for all depths.The depth range resolution was1 mm,and the maximum imaging depth of our system reached4.6 cm.Furthermore,blood vessels can be revealed and targeted depth range can be selected in nude mice imaging.
